Immunoglobulin Fab Fragments

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

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Networked: 416 relevant articles (25 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Reilly, Raymond M: 10 articles (11/2015 - 01/2005)
2.	Scollard, Deborah A: 6 articles (07/2013 - 01/2005)
3.	Allen, Theresa M: 5 articles (01/2013 - 01/2003)
4.	Lu, Yijie: 3 articles (11/2015 - 01/2013)
5.	Winnik, Mitchell A: 3 articles (11/2015 - 01/2013)
6.	Liu, Peng: 3 articles (11/2015 - 01/2013)
7.	Boyle, Amanda J: 3 articles (11/2015 - 01/2013)
8.	Moase, Elaine H: 3 articles (01/2013 - 01/2003)
9.	Morris, Timothy A: 3 articles (09/2012 - 11/2010)
10.	Nieswandt, Bernhard: 3 articles (01/2011 - 05/2007)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1983 - "The best results were obtained with Fab fragments of MAb 35, which gave clear detections of tumors weighing only 0.1 g as early as 48 h after injection. " 01/01/1986 - "The contrast of the tumor images obtained with Fab fragments suggests that this improved method of immunoscintigraphy has the potential to detect early tumor recurrences and thus to increase the survival of patients. " 01/01/2015 - "High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation." 10/01/2014 - "Because α-CTLA-4 Fab fragments had the same effect as the intact antibody, the higher T-cell motility does not seem to be due to CTLA-4 inhibitory signaling but rather to the release of nonproductive stable interactions between tumor-infiltrating T cells and tumor targets or antigen-presenting cells subsequent to CTLA-4 blockade. " 11/20/2013 - "Site specific discrete PEGylation of (124)I-labeled mCC49 Fab' fragments improves tumor MicroPET/CT imaging in mice."
2.	Poisoning 11/01/2008 - "First-line therapy with Fab fragments in patients with digitalis poisoning was associated with a low mortality rate." 11/01/2008 - "Despite administration of Fab fragments in digitalis poisoning, high mortality rates are consistently reported. " 05/01/2003 - "An AId Ab to mAb 3F3 Fab fragments has been prepared successfully, which opens up a novel way for treatment of pesticides poisoning." 10/01/2000 - "Poisoning with foxglove extract: favorable evolution without Fab fragments." 03/01/1991 - "The case reports cited in the medical literature and the 57 pediatric cases gathered as a result of the multicenter clinical trial and postmarketing surveillance study reported here indicate that digoxin-specific antibody Fab fragments are effective in ameliorating signs of digitalis poisoning in children. "
3.	Infection 04/15/1995 - "Also, this is the first report of in vivo protection against a viral infection by Fab fragments of antiviral Ab." 04/01/2015 - "Although Fab fragments of the mAbs prevented in vitro HCV infection, their inhibitory effects were much weaker than those of the whole mAbs. " 11/01/2014 - "Using Fab fragments and a neutropenic mouse model, we showed that 21RA and 24RA mediate protection from V. vulnificus infection through an Fc-independent and/or neutrophil-independent pathway. " 01/01/2008 - "Our results demonstrate that neither purified mAbs were capable of neutralizing HIV-2, while intact Fab fragments from both mAbs blocked in vitro infection of HIV-2 isolates. " 04/01/2003 - "Tc-99m-labeled antigranulocyte monoclonal antibody Fab' fragments can be used for imaging acute infections of peripheral bones and soft tissues. "
4.	Carcinoma (Carcinomatosis) 01/01/1986 - "Improved radioimmunolocalization of carcinomas using Fab fragments with anti-CEA specificity." 11/01/2003 - "We labeled chimeric (human/mouse) Fab fragments of Mab A7 (chA7Fab) with (99m)Tc and examined the distribution of (99m)Tc-labeled chA7Fab in nude mice bearing human pancreatic carcinoma. " 11/01/2003 - "Application of 99mTc labeled chimeric Fab fragments of monoclonal antibody A7 for immunoscintigraphy of pancreatic carcinoma." 01/01/2003 - "Isolation of human Fab fragments against ovarian carcinoma using guided selection." 03/01/1998 - "Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/1995 - "The results obtained in this preliminary study indicate the potential usefulness of MoAb PAM4 for immunoscintigraphy in patients with either primary and/or recurrent pancreatic cancer while also suggesting that the use of the faster-clearing Fab fragments of this MoAb probably would result in improved immunoscintigraphic properties." 04/01/1995 - "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer." 04/01/1995 - "In this study, 125I-labeled murine and chimeric Fab fragments of the MAb A7 were injected i.v. into nude mice bearing a human pancreatic cancer (HPC-YS) xenograft. " 12/01/1997 - "[Application of chimeric Fab fragments of monoclonal antibody A7 for targeting chemotherapy against pancreatic cancer]." 04/01/1995 - "These results suggests that chimeric Fab fragments of MAb A7 are useful carriers of radionuclides for the immunodetection of human pancreatic cancer, with equivalent activity to murine Fab fragments and less theoretical potential to induce a HAMA response."

Related Drugs and Biologics

1.	Digoxin (Digitek)
2.	Immunoglobulin G (IgG)
3.	Monoclonal Antibodies
4.	Antigens
5.	Doxorubicin (Adriamycin)
6.	digoxin antibodies Fab fragments (Fabad)
7.	Antibodies
8.	Vincristine (Oncovin)
9.	Epitopes
10.	Tetanus Antitoxin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Radioimmunotherapy
3.	Intravenous Injections
4.	Gamma Cameras (Gamma Camera)
5.	Mechanical Ventilators (Ventilator)