Immunoglobulin alpha-Chains

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.

Also Known As:

Immunoglobulin alpha-Chain; alpha-Chain Immunoglobulins; alpha-Immunoglobulin Heavy Chain; alpha-Immunoglobulin Heavy Chains; Chains, Ig alpha; Heavy Chain, alpha-Immunoglobulin; Heavy Chains, alpha-Immunoglobulin; Immunoglobulin alpha Chain; Immunoglobulin alpha Chains; Immunoglobulins, alpha Chain; alpha Chain Immunoglobulins; alpha Chains, Ig; alpha Immunoglobulin Heavy Chain; alpha Immunoglobulin Heavy Chains; alpha-Chain, Immunoglobulin; alpha-Chains, Immunoglobulin; Ig alpha Chains; Immunoglobulins, alpha-Chain

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Burgos, A: 1 article (01/2008)
2.	Kaplan, R: 1 article (01/2008)
3.	Meza Vetanzo, Z: 1 article (01/2008)
4.	Ortiz, S: 1 article (01/2008)
5.	Piccinni, D J: 1 article (01/2008)
6.	Rodriguez, N: 1 article (01/2008)

Related Diseases

1.	B-Cell Lymphoma (Lymphoma, B Cell) 10/01/1981 - "We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell lines, a B cell lymphoma that expresses membrane-bound IgA and a hybridoma that secretes IgA. "
2.	Neoplasms (Cancer) 01/01/1995 - "Two of the biopsies from dogs with cutaneous plasmacotyoma were shown to express immunoglobulin alpha chain (one with lambda chain) and two neoplasms were positive for immunoglobulin gamma chain (both with lambda chain). "
3.	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 12/01/1990 - "Alpha heavy chain diseases (HCD) are lymphoproliferative disorders characterized by the production of truncated alpha immunoglobulin heavy chain without associated light chains, alpha HCD MAL is featured by multiple structural alterations of the alpha 1 productive gene and on original t(9;14)(p11;q32) translocation involving the other rearranged alpha 1 allele. "
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2008 - "In high-grade lymphomas, the cells are large and pleomorphic, with immunoblastic and plasmacytoid features, and immunopositive for alpha chain immunoglobulins. "
5.	Lymphoma (Lymphomas) 08/11/1986 - "RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma synthesizing membrane-bound and secretory IgA and in a hybridoma which synthesizes predominantly secretory IgA. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Immunoglobulin gamma-Chains (gamma-Chain, Immunoglobulin)
3.	Secretory Immunoglobulin A (SIgA)
4.	Immunoglobulin A (IgA)