Immunoglobulin M (IgM)

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Also Known As:

Networked: 18713 relevant articles (481 outcomes, 1372 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Treon, Steven P: 33 articles (01/2015 - 04/2003)
2.	Gertz, Morie A: 29 articles (10/2015 - 01/2002)
3.	Ghobrial, Irene M: 27 articles (02/2015 - 11/2003)
4.	Blacksell, Stuart D: 25 articles (12/2015 - 04/2006)
5.	Kyle, Robert A: 24 articles (05/2015 - 01/2002)
6.	Prince, Harry E: 22 articles (03/2015 - 07/2002)
7.	Day, Nicholas P J: 21 articles (12/2015 - 08/2004)
8.	Frostegård, Johan: 20 articles (01/2014 - 09/2006)
9.	Rajkumar, S Vincent: 16 articles (05/2015 - 01/2002)
10.	Leleu, Xavier: 16 articles (04/2013 - 08/2007)

Related Diseases

1.	Infection 05/01/2011 - "These data provide evidence that panobacumab, an IgM-based immunotherapeutic, is highly efficacious in controlling acute lung infection by enhancing the natural innate immune response." 12/01/1989 - "The modified IHA test for the detection of IgM antibody was highly effective in the recognition of recent or current infection with the mycoplasma. " 11/01/1989 - "Although most assays may not detect low amounts of IgM antibody during the initial weeks of infection, application of a capture ELISA method has been reported to improve test sensitivity. " 09/01/2013 - "Use of IgM-capture enzyme-linked immunosorbent assay (ELISA) is important for the early diagnosis of EV71 infection, but cross-reactivity of the anti-CVA16 IgM antibody with EV71 produces false-positive results. " 03/15/2003 - "Immunoglobulin M is an especially important product of the immune system because it plays a critical role in early protection against infections. "
2.	Neoplasms (Cancer) 03/01/2001 - "Further, when mice were injected with varying doses of rabbit polyclonal anti-GT1b IgM antibody and challenged with Ehrlich tumor cells subcutaneously, a significant reduction in tumor growth (47.3%) was observed. " 12/01/2000 - "A significant reduction in tumor growth (65%) was observed in mice administered with anti-GT1b IgM antibody. " 01/01/1985 - "F(ab')2 fragments were cleared more rapidly than the whole IgM; the clearance was as fast in healthy as in tumor-bearing mice. " 04/01/2001 - "Therefore, we developed in this study a novel metastatic tumor model in nude rats that reflects the clinical appearance of human NB and used this model to study the therapeutic efficacy of human anti-NB IgM. " 08/01/1989 - "Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. "
3.	Rubella (German Measles) 07/01/2007 - "The study demonstrates that the ARCHITECT Rubella IgM assay shows improved specificity compared to AxSYM and Behring. " 08/01/1986 - "Therefore, borderline and low-positive results must be interpreted with caution, as for any assay for rubella-specific IgM." 03/01/1984 - "None of the 15 persons whose preimmunization sera produced positive results by LA when tested undiluted developed IgM rubella antibody, as compared with 10 of the 14 persons whose preimmunization sera produced negative results (P less than 0.001). " 08/01/1976 - "Serum specimens tested for rubella-specific IgM by the haemagglutination-inhibition technique may give false-positive results due to (a) storage at -20 degrees C, (b) bacterial contamination, or (c) inactivation at 56 degrees C. " 12/12/2014 - "All infants born during the study period with clinical manifestations of CRS and seropositivity (IgM) for rubella were included in this study. "
4.	Dengue (Dengue Fever) 07/01/2015 - "Combination of clinical findings and rapid NS1, IgM detection helped in confirming the diagnosis for appropriate management of dengue in children." 01/01/2011 - "Using a panel of well-characterized sera and a collection of retrospective samples obtained during the dengue epidemics that occurred in Belém, Brazil, between 2002 and 2009, a modified immunoglobulin M-specific capture enzyme-linked immunosorbent assay (Rapid-MAC-ELISA) was evaluated and compared with the "gold standard" MAC-ELISA, in order to assess the specificity, sensitivity, stability, reproducibility and cost-effectiveness of this new assay. " 12/01/2009 - "None of 87 patients who had positive results for dengue immunoglobulin M in the 2007 study group had maculopathy, whereas it was seen in 10% of the 2005 group (P = .002). " 01/01/2008 - "Comparison of PanBio dengue IgM ELISA assay with pentax dengue IgM particle agglutination assay to evaluate factors affecting false positive results." 12/01/1983 - "IgM-ELISA appeared to help differential diagnosis on JE from dengue even when the HI test did not give positive results."
5.	Measles 03/01/2012 - "Saliva test kits were sent to all cases and KS test properties were analysed against measles confirmation by PCR or IgM testing (gold standard). " 09/01/2011 - "The Microimmune measles IgM capture enzyme immunoassay was the gold standard for comparison. " 01/01/2002 - "Serological confirmation of cases suspected for measles improved too slowly (assay for IgM)--out of 107 suspected cases only 49 (47.6%) were serologically tested." 11/01/2013 - "The purpose of this study was to evaluate the diagnostic performance of LIAISON IgM measles (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with enzyme immunoassay (EIA) Enzygnost (Siemens, Marburg, Germany). " 04/01/2011 - "Of 242 suspected measles cases notified between 3rd and 48th calendar weeks of the study-year, laboratory result was IgM-positive for 46% cases, IgM-negative for 49% cases, and unknown for 5% cases. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Immunoglobulin A (IgA)
4.	Antigens
5.	Immunoglobulin M (IgM)
6.	Immunoglobulins (Immunoglobulin)
7.	Rheumatoid Factor
8.	Complement System Proteins (Complement)
9.	RNA (Ribonucleic Acid)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Splenectomy
4.	Aftercare (After-Treatment)
5.	Transplants (Transplant)