Ifosfamide

Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.

Also Known As:

Asta Z 4942; Holoxan; Iphosphamide; Iso-Endoxan; NSC-109,724; NSC-109724; Iso Endoxan; NSC 109,724; NSC 109724; NSC109,724; NSC109724; Isofosfamide; Isophosphamide; 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

Networked: 3556 relevant articles (379 outcomes, 1027 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Blay, Jean-Yves: 19 articles (12/2021 - 11/2005)
2.	Gronchi, Alessandro: 16 articles (12/2021 - 01/2014)
3.	Ferrari, Stefano: 14 articles (01/2022 - 11/2003)
4.	Picci, Piero: 14 articles (01/2022 - 05/2005)
5.	Le Cesne, Axel: 14 articles (01/2020 - 08/2006)
6.	Palmerini, Emanuela: 13 articles (01/2022 - 07/2007)
7.	Ferrari, Andrea: 12 articles (01/2022 - 04/2005)
8.	Grier, Holcombe E: 12 articles (10/2016 - 01/2002)
9.	Bisogno, Gianni: 11 articles (01/2022 - 11/2002)
10.	Casanova, Michela: 11 articles (01/2022 - 04/2005)

Related Diseases

1.	Neoplasms (Cancer) 11/30/2023 - "Although ifosfamide is effective against cancer, its potential kidney side effects should be carefully considered by doctors when deciding on the best treatment for each patient." 01/01/2021 - "Ifosfamide is a widely used chemotherapeutic agent having broad-spectrum efficacy against several tumors. " 12/01/1991 - "This low percentage (5%) of TDFS must be evaluated with respect to the efficacy of ifosfamide in the treatment of mesenchymal tumors in children." 01/01/2023 - "High-dose continuous-infusion ifosfamide in advanced thymic epithelial Tumors: A TYME network study." 11/01/2022 - "Methods: In this retrospective descriptive study, the author reviewed 7 years of clinical data regarding patients with solid tumors who received ifosfamide at a large, urban pediatric medical center. "
2.	Sarcoma (Soft Tissue Sarcoma) 10/18/2023 - "In this prospective, multicenter, one-stage, single-arm phase II trial, we assessed the combination of NPLD and ifosfamide as first-line treatment for advanced/metastatic soft tissue sarcoma (STS). " 11/17/2020 - "Ifosfamide is used to treat soft-tissue sarcoma (STS) and bone sarcoma (BS), with improved efficacy at doses above 9 g/m2/cycle. " 08/01/2000 - "Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcoma." 01/01/2015 - "This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic soft tissue sarcoma. " 07/01/2011 - "The aim of present study was to determine the frequency and severity of ifosfamide nephropathy in patients with various types of sarcoma. "
3.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2005 - "To explore the effect of high-dose ifosfamide in first-line treatment for patients < or = 40 years of age with nonmetastatic osteosarcoma of the extremity. " 09/01/2018 - "Overall, nanoparticulate formulations of Ifosfamide enhanced the therapeutic efficacy in osteosarcoma." 01/01/2020 - "This study suggests that ifosfamide is an effective second-line treatment for patients with recurrent/metastatic osteosarcoma. " 01/01/2020 - "In this study we report our single-center experience with second-line ifosfamide monotherapy in patients treated for recurrent/metastatic osteosarcoma. " 09/01/2018 - "The present study aimed to isolate CTCs by using a pre-clinical model of human osteosarcoma and to monitor their kinetic of release and their modulation by ifosfamide. "
4.	Lymphoma (Lymphomas) 08/01/1999 - "Several regimens incorporating ifosfamide in a variety of doses and schedules have demonstrated clinical efficacy in the treatment of lymphomas. " 07/01/1991 - "We report the results of two phase II trials of ifosfamide in very high risk patients with either partially responsive or recurrent non-Hodgkin's lymphomas. " 12/01/1982 - "Studies with ifosfamide in patients with malignant lymphoma." 01/01/2003 - "Ifosfamide has been mainly used, in combination with other drugs, as a component of salvage regimens for relapsed or primarily refractory lymphoma. " 01/01/2003 - "Future perspectives in the treatment of malignant lymphomas: focus on ifosfamide. "
5.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 02/01/1989 - "Numerous trials in Europe and at Indiana University have confirmed single-agent activity of ifosfamide in patients with refractory germ cell tumors. " 01/01/2003 - "Ifosfamide has always had significant single-agent activity in patients with germ cell tumors. " 01/01/2003 - "Ifosfamide in germ cell tumors." 06/01/1996 - "Ifosfamide in the treatment of germ cell tumors." 01/01/1986 - "Ifosfamide in refractory male germ cell tumors."

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Cisplatin (Platino)
3.	Doxorubicin (Adriamycin)
4.	Carboplatin (JM8)
5.	Cyclophosphamide (Cytoxan)
6.	Mesna (Coenzyme M)
7.	Vincristine (Oncovin)
8.	Paclitaxel (Taxol)
9.	Methotrexate (Mexate)
10.	Epirubicin (Ellence)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Salvage Therapy
5.	Radiotherapy