L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)

An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14

Also Known As:

Networked: 166 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Sookja K: 4 articles (09/2010 - 11/2007)
2.	Harrill, Alison H: 2 articles (06/2014 - 01/2014)
3.	Watkins, Paul B: 2 articles (06/2014 - 01/2014)
4.	Travlos, G S: 2 articles (01/2014 - 04/2001)
5.	Li, Qing: 2 articles (09/2011 - 01/2008)
6.	Ramasamy, Ravichandran: 2 articles (09/2011 - 01/2008)
7.	Ananthakrishnan, Radha: 2 articles (09/2011 - 01/2008)
8.	Tang, Wai Ho: 2 articles (09/2010 - 07/2010)
9.	Kravtsov, Gennadi M: 2 articles (09/2010 - 07/2010)
10.	Hou, Xiu Yun: 2 articles (09/2010 - 07/2010)

Related Diseases

1.	Diabetes Complications 05/31/2013 - "Sorbitol dehydrogenase inhibitors have been found to prevent, or alleviate, various secondary complications of diabetes mellitus. " 08/01/1998 - "Several recent studies with the sorbitol dehydrogenase inhibitors 4-[4-(N,N-dimethylsulfamoyl)-piperazino]-2-methylpyrimidine, SDH-1, and its active metabolite 4-[4-(N, N-dimethylsulfamoyl)piperazino]-2-hydroxymethylpyrimidine , SDH-2, suggest that inhibition of sorbitol dehydrogenase may be beneficial in delaying the onset of diabetic complications due to their ability to ameliorate redox changes associated with polyol metabolism. " 08/01/2002 - "[Effects of transgenic human aldose reductase and sorbitol dehydrogenase deficiency on diabetes complications]." 07/01/1999 - "Both Zn++ and Cu++ show a concentration-dependent inactivation of a protease essential for the proliferation of the AIDS virus HIV-1, while zinc can help prevent diabetes complications through its intracellular activation of the enzyme sorbitol dehydrogenase (SDH). " 08/15/1996 - "Sorbitol dehydrogenase (SDH) is involved in the polyol pathway, which plays an important role in the pathogenesis of diabetic complications. "
2.	Necrosis 01/01/2015 - "The data demonstrated that sorbitol dehydrogenase inhibitor (SDI)-administration significantly alleviated I/R-induced liver injury, palliated histological changes and lowered the level of hepatocyte apoptosis and necrosis. " 04/01/1993 - "Severe congestion and necrosis of the liver was present in moribund mice; hepatic congestion and serum alanine aminotransferase and sorbitol dehydrogenase were significantly greater in moribund animals." 07/01/2001 - "Hepatocellular necrosis was suggested by increased serum activities of alanine aminotransferase and sorbitol dehydrogenase in all exposed groups of males and in 10 mg/m3 or greater females and was confirmed microscopically in 100 mg/m3 males and females. " 03/01/2001 - "Elevated plasma sorbitol dehydrogenase activity and centrilobular hepatocellular necrosis was present in control mice receiving APAP at 12 and 24 h. " 01/01/2000 - "YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the necrosis induced by AlOH. "
3.	Experimental Diabetes Mellitus 09/01/1964 - "HISTOCHEMICAL STUDY ON THE ACTIVITY OF SORBITOL DEHYDROGENASE IN RATS WITH EXPERIMENTAL DIABETES MELLITUS." 05/25/1994 - "Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat?" 05/25/1994 - "This study examined the response of sorbitol dehydrogenase gene expression to streptozotocin-diabetes (STZ-diabetes) in the rat and whether these changes were reversed by insulin. " 07/01/1980 - "Experiments were conducted on rats with prolonged (6-9 months) alloxan diabetes; a study was made of the effect of naphthylimidoacetic acid (NIAA) on the blood glucose, fructose, cholesterol and sorbitol dehydrogenase level and also on the intensity of developing microangiopathies, according to biomicroscopy of the iris and electron microscopy of the muscle capillaries. "
4.	Ischemia 01/01/2015 - "Sorbitol dehydrogenase (SDH), a key enzyme of the polyol pathway, has recently been demonstrated to have an important role in mediating tissue ischemia/reperfusion (I/R) injury. " 01/01/2015 - "Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity." 03/15/1988 - "In this ewe, and in 4 of 7 other sheep diagnosed as having abomasal emptying defects, aspartate transaminase and sorbitol dehydrogenase activities were high, and histopathologic evidence of hepatic congestion and ischemia was found. " 09/01/2011 - "To test our hypothesis, we determined the expression and products of PP enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in hearts from Fischer 344 aged (26 months) and young (4 months) rats subjected to global ischemia followed by reperfusion in the presence or absence of blockers of PP and the measures of ischemic injury and functional recovery were determined. " 01/01/2008 - "We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. "
5.	Cataract (Cataracts) 11/01/2008 - "The contribution of osmotic and oxidative stress in cataract development in sorbitol dehydrogenase (SDH) deficient mice, a model for slow-developing cataract in diabetic patients was determined. " 08/01/2004 - "In contrast, the inhibition of sorbitol dehydrogenase by 4-[4-(N,N-dimethylsulfamoyl)piperazino]-2-hydroxymethylpyrimidine (SDI-1) has been observed to increase the onset in severity of sugar cataract formation in diabetic rats. " 04/01/1993 - "Little is known about the sorbitol-dehydrogenase (SDH) activity in diabetic patients, although cataract is described in diabetes as well as in SDH deficiency. " 11/01/1987 - "Quantitative screening for red blood cell sorbitol dehydrogenase (RBC-SORD) deficiency in 111 patients with juvenile onset diabetes, 92 patients with adult onset diabetes, 42 patients with idiopathic cataracts and 192 professional blood donors was performed. " 11/01/1987 - "Screening for red blood cell sorbitol dehydrogenase deficiency in patients with diabetes or cataracts."

Related Drugs and Biologics

1.	polyol
2.	Alanine Transaminase (SGPT)
3.	Aldehyde Reductase (Aldose Reductase)
4.	Aspartate Aminotransferases (Aspartate Transaminase)
5.	Sorbitol (Yal)
6.	Alkaline Phosphatase
7.	Glutamate Dehydrogenase
8.	Retinaldehyde (Retinal)
9.	Fructose
10.	Cholesterol

Related Therapies and Procedures

1.	Lenses
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Cardiopulmonary Resuscitation (CPR)
4.	Sutures (Suture)
5.	Intramuscular Injections