Ibogaine (Endabuse)

One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.

Also Known As:

Networked: 157 relevant articles (20 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barsuglia, Joseph P: 4 articles (01/2020 - 11/2017)
2.	Hilber, Karlheinz: 4 articles (01/2017 - 12/2013)
3.	Koenig, Xaver: 4 articles (01/2017 - 12/2013)
4.	Mash, D C: 4 articles (07/2006 - 09/2000)
5.	Belgers, Maarten: 3 articles (01/2022 - 12/2018)
6.	Knuijver, Thomas: 3 articles (01/2022 - 12/2018)
7.	Schellekens, Arnt: 3 articles (01/2022 - 12/2018)
8.	Mash, Deborah C: 3 articles (09/2021 - 01/2016)
9.	Carrera, Ignacio: 3 articles (07/2021 - 01/2018)
10.	Ron, Dorit: 3 articles (01/2021 - 01/2005)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 09/01/2000 - "The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. " 09/01/1996 - "The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. " 07/01/1994 - "Ibogaine may be of value in the present and could serve as a model for the development of improved agents for the treatment of substance abuse in the future." 07/01/2017 - "While this study is limited in generalizability due to high attrition and low sample size, it deepens the understanding of the phenomenological experience of ibogaine and explores the possible utility of ibogaine in the treatment of substance use disorders." 07/01/2016 - "While rigorous trials are required to establish safety and efficacy, future studies should seek to delineate the potential role of ibogaine or other molecules that may produce transformative experiences for individuals with substance use disorder."
2.	Opioid-Related Disorders (Opiate Addiction) 05/30/1998 - "Ibogaine may have antiaddiction potential against alcohol, psychostimulant and opiate abuse, but its mechanism of action is unclear. " 05/01/1998 - "Ibogaine may have antiaddiction potential against alcohol, psychostimulant and opiate abuse, but its mechanism of action is unclear. " 07/01/2016 - "Remission of Severe Opioid Use Disorder with Ibogaine: A Case Report." 01/01/2022 - "This study aimed to evaluate the cardiac, cerebellar and psychomimetic safety of ibogaine in patients with opioid use disorder. " 09/01/2021 - "Evaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse."
3.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 11/01/2017 - "Most (80%) indicated that ibogaine eliminated or drastically reduced withdrawal symptoms. " 06/01/2004 - "Furthermore, both anecdotal observations and recent studies suggest that ibogaine alleviates withdrawal symptoms and reduces drug cravings. " 01/01/2022 - "The published data suggest that ibogaine is an effective therapeutic intervention within the context of SUDs, reducing withdrawal symptoms and craving. " 03/01/2013 - "Preclinical research has generally supported anecdotal claims that ibogaine attenuates withdrawal symptoms and reduces drug cravings. " 07/10/2006 - "The simplification of the ibogaine structure appears as a promising approach toward the design of compounds that could reduce the withdrawal symptoms."
4.	Cocaine-Related Disorders (Cocaine Addiction) 09/14/1993 - "These results indicate that ibogaine or its metabolite(s) is a long-lasting interruptor of cocaine dependence, which supports similar observations from uncontrolled clinical studies." 05/30/1998 - "The Neurochemistry of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines. " 10/31/1996 - "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines. " 07/01/1993 - "Reports that ibogaine may have potent anti-addictive properties have led to initiatives that it be tested for the treatment of opiate and cocaine addiction. " 03/03/1992 - "Although high doses of cocaine can become aversive by producing an anxiogenic reaction, it is unknown whether the potentiation of cocaine's effects by ibogaine would also cause aversion and lead to a decrease in cocaine addiction."
5.	Alcoholism (Alcohol Abuse) 01/01/2018 - "A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder." 01/01/2018 - "In this case, serial administration of ibogaine and 5-MeO-DMT resulted in increased perfusion in multiple brain regions broadly associated with alcohol use disorders and known pharmacology of both compounds, which coincided with a short-term therapeutic outcome. " 01/01/2011 - "The need for ibogaine in drug and alcohol addiction treatment." 05/01/1994 - "Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. " 01/01/2021 - "Our findings add to the literature suggesting that psychedelics, in particular ibogaine, may have therapeutic properties for the treatment of alcohol use disorder at doses that do not have rewarding effects per se."

Related Drugs and Biologics

1.	Alkaloids
2.	Opioid Analgesics (Opioids)
3.	noribogaine
4.	Hallucinogens (Psychedelics)
5.	Morphine (MS Contin)
6.	Opiate Alkaloids
7.	Indole Alkaloids
8.	Cocaine (Cocaine HCl)
9.	N-Methylaspartate (NMDA)
10.	indole

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Complementary Therapies (Alternative Medicine)
4.	Self Administration (Administration, Self)
5.	Induced Heart Arrest (Cardioplegia)