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Induced Hypothermia

Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
Also Known As:
Hypothermia, Induced; Mild Hypothermia, Induced; Moderate Hypothermia, Induced; Targeted Temperature Management; Therapeutic Hypothermia; Hypothermia, Therapeutic; Induced Mild Hypothermia; Induced Mild Hypothermias; Induced Moderate Hypothermia; Induced Moderate Hypothermias; Mild Hypothermias, Induced; Moderate Hypothermias, Induced; Targeted Temperature Managements
Networked: 5157 relevant articles (449 outcomes, 933 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1. Friberg, Hans: 75 articles (01/2021 - 07/2004)
2. Nielsen, Niklas: 70 articles (09/2021 - 07/2004)
3. Hassager, Christian: 61 articles (09/2022 - 01/2006)
4. Lee, Byung Kook: 58 articles (06/2022 - 11/2012)
5. Kjaergaard, Jesper: 45 articles (09/2022 - 01/2006)
6. Thoresen, Marianne: 45 articles (12/2021 - 04/2005)
7. Cronberg, Tobias: 45 articles (01/2021 - 07/2004)
8. Holzer, Michael: 44 articles (02/2022 - 07/2003)
9. Abella, Benjamin S: 43 articles (12/2021 - 02/2005)
10. Jeung, Kyung Woon: 40 articles (06/2022 - 11/2012)

Related Diseases

1. Heart Arrest (Cardiac Arrest)
2. Out-of-Hospital Cardiac Arrest
3. Coma (Comas)
4. Hypothermia
11/01/2019 - "In conclusion, although electrographic recovery was partially improved by slow rewarming over 24 h following cerebral hypothermia for 48 h, optimal neuroprotection was seen with hypothermia for 72 h with rapid rewarming, suggesting that the overall duration of cooling was the critical determinant of outcomes after therapeutic hypothermia."
01/01/2011 - "On review, our findings revealed that the protective effects of induced mild hypothermia (33°C) were limited, and the therapeutic time window of even moderate hypothermia (30°C) was very short in our specific models, although this limitation might be due to the relatively brief periods of hypothermia used. "
04/01/2010 - "Taking into consideration all results from clinical hypothermia TBI studies discussion has to be focused around the possibility that a better outcome could be achieved if protocols for therapeutic hypothermia are reviewed. "
01/03/2012 - "In a rat model of cardiopulmonary resuscitation, a shorter duration of mild hypothermia induced rapidly and early after restoration of spontaneous circulation improved postresuscitation microcirculation, myocardial and cerebral functions, and survival as well as, or better than, prolonged duration of hypothermia after resuscitation."
05/15/2003 - "Although efficacy of hypothermia in improving functional outcome of mild to moderate traumatic SCI has been demonstrated, hypothermia may not be protective against severe traumatic SCI. At present, induced hypothermia has yet to be recognized or approved as a potential treatment having therapeutic value for traumatic SCI in humans. "
5. Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain)

Related Drugs and Biologics

1. Neuroprotective Agents
2. Oxygen (Dioxygen)
3. Phenobarbital (Luminal)
4. Biomarkers (Surrogate Marker)
5. Xenon
6. Mannitol (Osmitrol)
7. Neurotensin Receptors (Neurotensin Receptor)
8. Anesthetics (Anesthetic Agents)
9. Hypnotics and Sedatives (Sedatives)
10. Glyburide (Glibenclamide)

Related Therapies and Procedures

1. Resuscitation
2. Therapeutics
3. Cardiopulmonary Resuscitation (CPR)
4. Induced Hypothermia
5. Rewarming