Hypoproteinemia

A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.

Also Known As:

Networked: 1015 relevant articles (52 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Proteinuria
3.	Hyperlipidemias (Hyperlipidemia)
4.	Weight Loss (Weight Reduction)
5.	Pleural Effusion (Pleural Effusions)

Experts

1.	Suzuki, Hiromichi: 4 articles (02/2005 - 11/2002)
2.	Fu, Mingming: 3 articles (07/2022 - 01/2022)
3.	Hou, Zhiyong: 3 articles (07/2022 - 01/2022)
4.	Wang, Zhiqian: 3 articles (07/2022 - 01/2022)
5.	Liu, Yan: 3 articles (01/2022 - 01/2015)
6.	Nomura, Ichiro: 3 articles (01/2021 - 08/2002)
7.	Ohya, Yukihiro: 3 articles (01/2021 - 08/2002)
8.	Wang, Hong: 3 articles (01/2021 - 06/2009)
9.	Wang, Wei: 3 articles (02/2020 - 01/2018)
10.	Sanaka, Tsutomu: 3 articles (06/2004 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoproteinemia:

1.	Proteins (Proteins, Gene)FDA Link 11/01/2003 - "If there is a patient with severe hypoproteinemia and preserved levels of rapid turnover proteins, protein-losing gastroenteropathy should be suspected and we get a strong proof to do the following examinations such as a fecal clearance of alpha-1 antitrypsin." 02/28/1935 - "The data permit one to entertain the hope that a way will be found for stimulating an internal readjustment to provide temporary relief from hypoproteinemia, a way which will depend upon the potential ability of the tissues to provide sufficient protein for the needs of the plasma." 01/01/2019 - "The two patients experiencing hypoproteinemia improved protein levels following CCL. " 09/02/2022 - "BACKGROUND Hypoproteinemia is caused by a decrease in protein level in the blood. " 09/01/2021 - "All cases with AL had hypoproteinemia; a protein level < 5 g/dl was an independent risk factor for AL (p value 0.009). "
2.	Anti-Bacterial Agents (Antibiotics)IBA 07/02/1997 - "Anemia and hypoproteinemia responded well to a treatment with cotrimotazole but relapsed after discontinuation of the antibiotics." 06/01/1994 - "Hypoproteinemia and inflammatory changes of the intestine were improved by antibiotics, suggesting that the inflammatory lesion was caused by bacterial infection. " 01/01/2020 - "Multivariate analysis showed that ECOG performance status ≥two scores, length of antibiotic treatment <9.0 days, existence of septic shock, and hypoproteinemia were independent risk factors for in-hospital mortality. " 11/01/1999 - "RESULTS: Case report of a girl two years and seven months old, previously healthy, with a clinical picture of chronic diarrhea with dysenteric characteristics after the use of antibiotics, associated with important weight lost and hypoproteinemia. " 06/01/2019 - "Age >60 years, multiple hospitalization, length of hospital stay >20 days, hypoproteinemia, CDC, hepatic encephalopathy, and exposure of antibiotics and PPI were risk factors for CDI in cirrhotic patients. "
3.	Blood Proteins (Serum Proteins)IBA 12/01/2019 - "This results in hypoproteinemia due to loss of serum proteins across the gastric mucosa. " 01/01/2017 - "These measures were analyzed in relationship to hypoproteinemia (total plasma protein level <40 g/L at 12 h of life) and severe adverse outcome (death or survival with severe neurological injury). " 01/01/2013 - "The adjusted odd ratio (aOR) and 95% confidence interval (95% CI) of severe adverse outcome for hypoproteinemia (total plasma protein level <40 g/L) was calculated by univariate and multivariate analyses. " 09/01/2000 - "Although various drugs used by anesthesiologists highly bind to plasma proteins, the impact of iatrogenically induced hypoproteinemia on their pharmacologic effects has never been investigated. " 11/01/1999 - "A 38-year-old Japanese male presented with hypoproteinemia (total serum protein: 4.4 g/dl). "
4.	ElectrolytesIBA 01/01/2021 - "All participants improved hypoproteinemia and electrolyte abnormalities with AD treatment alone, without intravenous fluids. " 08/15/2022 - "Multivariable logistic regression showed integrated management bundle was independent protective factor of hypoproteinemia, and electrolyte disturbance. " 08/15/2022 - "Incidence of hypoproteinemia, and electrolyte disturbance in integrated management bundle group was significantly lower than multidisciplinary management group (all P < 0.05). " 01/01/2022 - "A blood test revealed electrolyte disturbance and hypoproteinemia. " 01/01/2020 - "1 patient experienced temporary water-electrolyte disorder and hypoproteinemia. "
5.	IronIBA 11/01/1992 - "Hypoproteinemia and severe iron deficiency anemia in both of these patients were improved by oral iron intake and prohibiting of cow's milk. " 06/01/2016 - "In the present case, the anemia and hypoproteinemia were eliminated following red blood cell transfusion and intravenous iron therapies. " 01/01/1956 - "When the iron preparation was given repeatedly over prolonged intervals, however, the proteinuria persisted and became extreme, and hypoproteinemia developed, often with hypercholesterolemia and transitory edema as well. " 01/01/2000 - "The analysis of early postoperative complications has established, that it a reasonable to perform such operations 1-3 years after gastroplasty when body weight stabilizes and there are no vitamin deficiency, iron deficient anemia, hypoproteinemia, hydroionic disturbances or other complications of the later period. " 02/15/2021 - "Anemia was determined in 31.6%, serum iron 33%, hypoproteinemia 12.6%, hypoalbuminemia 12%, hypokalemia 5.48%, hypocalcemia 21.9%. "
6.	Human Serum AlbuminFDA LinkGeneric 06/01/1991 - "Human serum albumin is used to treat hypoproteinemia in neonates or used as a volume expander. " 01/01/1980 - "Human albumin was infused into patients with hypoproteinemia and hypovolaemia as well as to surgical patients with normovolaemia. " 05/01/1962 - "[On a case of idiopathic hypoproteinemia studied by means of radioiodinated human serum albumin]." 03/01/2021 - "Single-center analysis of the inappropriate use of human albumin and nutritional support in hospitalized patients with hypoproteinemia in China." 08/01/2003 - "Exogenous rhGH in treating hypoproteinemia in patients with liver cirrhosis is more effective than human albumin."
7.	gamma-Globulins (gamma-Globulin)IBA 10/01/1980 - "We describe a case of Ménétrier's disease accompanied by severe hypoproteinemia with marked decrease of gamma globulin. " 01/01/1954 - "[Apparently essential hypoproteinemia with gamma globulin deficiency in a 2-year-old child]." 08/01/1949 - "Immunochemical estimation of the rate of disappearance of transfused gamma globulin from the blood in two cases of hypoproteinemia." 01/01/1962 - "[Hypothrepsia secondary to chronic hypoproteinemia involving the beta and gamma globulin fractions greatly improved by a gluten-free diet]." 09/01/2015 - "Biochemical analysis revealed hypoproteinemia, hypoalbuminemia, and hyperglobulinemia especially gamma globulins. "
8.	oxidized low density lipoproteinIBA 06/01/2015 - "Along with rapid improvement of hyperlipidemia, LDL-A significantly improved proteinuria and hypoproteinemia after treatment. " 01/01/2015 - "The dialysis duration was positively correlated with the blood pressure, SGA scores, TG, LDL, PTH, CRP, and LOT-R scores, but negatively correlated with Kt/V. Our results suggest that hypertension, anemia, hypoproteinemia, SGA, TG, LDL, iPTH, CRP, Kt/V, and personalities are potentially important factors affecting the prognosis of ERSD patients with CAPD. " 08/01/2008 - "We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. " 10/01/1990 - "Because the reduced plasma oncotic pressure from hypoproteinemia causes hyperlipidemia, serum albumin levels should be maintained during low-density lipoprotein (LDL) apheresis. " 08/25/2022 - "Multivariate Logistic regression analysis showed that osteoporosis (OR=3.116, 95%CI:1.816-5.346, P<0.001), hypoproteinemia (OR=2.508, 95%CI:1.583-3.974, P<0.001), preoperative serum LDL>4.645 mmol/L(OR=2.586, 95%CI:1.394-4.798, P<0.001), plasma D-D>558.00 ng/ml (OR=23.916, 95%CI:15.108-37.860, P<0.001), FDP>13.81 µg/ml(OR=3.873, 95%CI:2.614-5.739, P<0.001) and age were independent risk factors for the occurrence of DVT before spinal fracture surgery, and the incidence of DVT in patients aged 36-50, 51-65 and over 65 years was 2.49, 2.59 and 4.02 times of those aged 18-35 years, respectively. "
9.	Tranexamic Acid (AMCA)FDA Link 01/01/1978 - "It was concluded that trans-AMCHA was effective in raising his serum protein to a certain extent but failed to block the vicious circle of "mucosal disorder", "increased tissue fibrinolysis" and "hypoproteinemia" (Kondo, M. " 03/01/1979 - "It is concluded that tranexamic acid appeared to be successful in blocking the vicious circle of "membrane disorder","increased tissue fibrinolysis", "increased vascular permeability", and "hypoproteinemia" in protein-losing gastroenteropathy." 01/01/1978 - "The patients were given antifibrinolytic therapy with oral tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid; trans-AMCHA), and four of the patients showed marked improvement of their hypoproteinemia as well as their mucosal disorders. "
10.	AlbuminsIBA 04/01/1960 - "[Study of idiopathic hypoproteinemia by administration of albumin combined with radioiodine]." 05/25/2022 - "Albumin level was lower in the B-II reconstruction group than that in the B-I reconstruction group (W=482.5, P=0.036), and the proportion of patients with hypoproteinemia (albumin <40 g/L) was also higher in the B-II reconstruction group (19/125, 15.2%) than that in the B-I reconstruction group (0/19) in the fifth year group, but the difference was not statistically significant (χ(2)=0.341, P=0.164). " 02/01/2021 - "The mean free fraction of MPA in our patients was 0.89% (ranging from 0.62 to 1.25%) and albumin level played a major role in the variability of free fraction of MPA, thus, in pediatric patients with hypoproteinemia, close free drug monitoring and dose adjustments should be considered to prevent toxicity." 01/01/2016 - "Preeclamptic women were retrospectively divided into mild hypoproteinemia (MHP, n = 220) and severe hypoproteinemia (SHP, n = 79) PE according to the value of albumin. " 11/01/2010 - "Blood CRP, PCT and WBC levels in the mild hypoproteinemia group were higher than those in the normal albumin group (P<0.05), and the severe hypoproteinemia group showed more increased blood CRP, PCT and WBC levels compared with the mild hypoproteinemia group (P<0.05). "

Therapies and Procedures

1.	Therapeutics 11/30/1957 - "[Splenoportographic study of a case of hypoproteinemia & hypocholesterinemia after gastric resection: response to therapy]." 06/01/2014 - "The hypoproteinemia was normalized after the therapy. " 12/01/1998 - "pylori is recommended therapy for the immediate improvement of Ménétrier's disease associated with hypoproteinemia." 01/01/1993 - "On the other hand, in patients without hypoproteinemia, worsening of renal function is most likely due to active primary disease and is probably not associated with MP pulse therapy." 09/01/1971 - "[Clinical aspects and therapy of serious hypoproteinemias in early childhood]."
2.	Gastrectomy 01/01/2021 - "In multivariate Cox regression analysis, hypoproteinemia [hazard ratio (HR) 1.522, 95% CI 1.085 to 2.137, p = 0.015] and high NLR level (HR 1.446, 95% CI 1.022 to 2.047, p = 0.021) were two independent poor prognostic factors, while previous radical gastrectomy was associated with a favorable OS (HR 0.345, 95% CI 0.205 to 0.583, p = 0.000). " 07/01/1978 - "As a treatment for the diffuse type of Ménétrier's disease, subtotal gastrectomy was recommended by presenting enough recovery from hypoproteinemia. " 01/01/1967 - "[Syndrome of hypoproteinemia after partial gastrectomy]." 01/01/1947 - "[Prophylaxis of hypoproteinemia in the immediate postoperative period after sub-total gastrectomy: transgastric jejunal feeding]." 10/01/2013 - "The patient underwent a laparoscopy-assisted total gastrectomy, and her anemia and hypoproteinemia improved. "
3.	Aftercare (After-Treatment) 08/01/2017 - "The EP was commonly accompanied with hypoproteinemia, and changed into psoriasis vulgaris after treatment. " 10/25/2021 - "There were 48 cases complicated with pneumonia, among which 9 cases had pulmonary inflammation before operation;27 cases with pleural effusion, 3 cases with acute heart failure, 3 cases with acute renal insufficiency, except one case died of pneumonia, pleural effusion, hypoproteinemia and respiratory failure during hospitalization, the other patients recovered after treatment. " 07/01/1969 - "Hypoproteinemia in mice after treatment with histamine-sensitizing factor from Bordetella pertussis." 06/01/2015 - "Along with rapid improvement of hyperlipidemia, LDL-A significantly improved proteinuria and hypoproteinemia after treatment. " 09/01/1976 - "Detailed studies of protein metabolism were undertaken in a patient with pellagra and hypoproteinemia associated with the carcinoid syndrome both before and after treatment. "
4.	Plasmapheresis 07/01/1992 - "To induce hypoproteinemia, we subjected each animal to 3 days of batch plasmapheresis (6 units per day). " 02/01/1986 - "Effects of plasmapheresis and of hypoproteinemia on lung liquid conductance in awake sheep." 07/01/1950 - "Effect of hypoproteinemia produced by plasmapheresis on plasma and interstitial fluid volumes and renal clearances of dogs." 06/01/1988 - "Measurements during hypoproteinemia were obtained during a 5-day recovery period starting 20 h after the final plasmapheresis session, with continued low-protein diet. " 09/01/1986 - "In 6 newborns with acute renal failure, Rh-ery-throblastosis and hypoproteinemia, 13 single-needle-diafiltrations and 6 single-needle-plasmapheresis were performed with the self-constructed double head pump, special tube systems and small models. "
5.	Total Parenteral Nutrition 01/01/2002 - "Following 5 weeks of total parenteral nutrition, his symptoms and hypoproteinemia improved and he was discharged, although follow-up colonoscopic findings revealed no improvement. " 09/01/1994 - "Despite tube thoracostomies and the initiation of total parenteral nutrition, massive losses of chyle persisted, resulting in hypoproteinemia and severe lymphopenia. " 01/01/1982 - "Tube feeding with an elemental or a low residue diet and total parenteral nutrition were prescribed to treat the hypoproteinemia and anemia. " 01/01/1979 - "In addition, parenteral hyperalimentation and Rheomacrodex-Sorbit may be indicated, but the hypoproteinemia should at any rate be corrected." 10/01/1999 - "The most significant metabolic/nutritional complication was the appearance of hypoproteinemia (hypoalbuminemia) in 1 distal RYGB patient 20 months after surgery, which was corrected by total parenteral nutrition and subsequent increase in dietary protein intake. "