Hypoproteinemia

A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.

Also Known As:

Networked: 534 relevant articles (26 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Proteinuria
3.	Hyperlipidemias (Hyperlipidemia)
4.	Hypertrophy
5.	Hypertrophic Gastritis (Giant Hypertrophic Gastritis)

Experts

1.	Suzuki, Hiromichi: 4 articles (02/2005 - 11/2002)
2.	Kobayashi, Keiko: 3 articles (04/2006 - 11/2004)
3.	Saheki, Takeyori: 3 articles (04/2006 - 11/2004)
4.	Sanaka, Tsutomu: 3 articles (06/2004 - 03/2003)
5.	Nakamoto, Hidetomo: 3 articles (12/2003 - 11/2002)
6.	Hirano, Tsutomu: 2 articles (06/2015 - 04/2014)
7.	Wang, Hong: 2 articles (03/2015 - 06/2009)
8.	Wang, Li: 2 articles (10/2014 - 09/2004)
9.	Li, Dan: 2 articles (10/2014 - 06/2009)
10.	Wang, Yu: 2 articles (04/2010 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoproteinemia:

1.	gamma-Globulins (gamma-Globulin)IBA 10/01/1980 - "We describe a case of Ménétrier's disease accompanied by severe hypoproteinemia with marked decrease of gamma globulin. " 01/01/1962 - "[Hypothrepsia secondary to chronic hypoproteinemia involving the beta and gamma globulin fractions greatly improved by a gluten-free diet]." 01/01/1960 - "[Chronic idiopathic hypoproteinemia involving the albumin gamma globulin fractions. " 01/01/1954 - "[Apparently essential hypoproteinemia with gamma globulin deficiency in a 2-year-old child]." 08/01/1949 - "Immunochemical estimation of the rate of disappearance of transfused gamma globulin from the blood in two cases of hypoproteinemia."
2.	Anti-Bacterial Agents (Antibiotics)IBA 07/02/1997 - "Anemia and hypoproteinemia responded well to a treatment with cotrimotazole but relapsed after discontinuation of the antibiotics." 06/01/1994 - "Hypoproteinemia and inflammatory changes of the intestine were improved by antibiotics, suggesting that the inflammatory lesion was caused by bacterial infection. " 01/01/2012 - "The main risk factors for these patients were days of hospitalization, history of IPFI, agranulocytosis, concomitant hypoproteinemia, number of antibiotics being used, concomitant bacterial sepsis, and age. " 10/01/1984 - "The virulent aggressive infection, bacteria resistant to antibiotics, the aggressive local infection, hypoproteinemia, anaemia, diabetes, a prolonged corticosteroid treatment and unsuitable antibiotic treatment are discussed as main factors predisposing to sepsis. " 10/01/2014 - "Univariate analysis showed that antibiotics use (P = 0.853), proton pump inhibitor use (P = 0.718), hypoproteinemia (P = 0.139) and white blood cell count (P = 0.454) did not appear to be associated with acquisition of CDAD in cancer patients. "
3.	Tranexamic Acid (AMCA)FDA Link 01/01/1978 - "It was concluded that trans-AMCHA was effective in raising his serum protein to a certain extent but failed to block the vicious circle of "mucosal disorder", "increased tissue fibrinolysis" and "hypoproteinemia" (Kondo, M. " 03/01/1979 - "It is concluded that tranexamic acid appeared to be successful in blocking the vicious circle of "membrane disorder","increased tissue fibrinolysis", "increased vascular permeability", and "hypoproteinemia" in protein-losing gastroenteropathy." 01/01/1978 - "The patients were given antifibrinolytic therapy with oral tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid; trans-AMCHA), and four of the patients showed marked improvement of their hypoproteinemia as well as their mucosal disorders. "
4.	IronIBA 11/01/1992 - "Hypoproteinemia and severe iron deficiency anemia in both of these patients were improved by oral iron intake and prohibiting of cow's milk. " 02/01/2012 - "Laboratory evaluation revealed iron deficiency along with hypoproteinemia and hypoalbuminemia. " 01/01/1956 - "When the iron preparation was given repeatedly over prolonged intervals, however, the proteinuria persisted and became extreme, and hypoproteinemia developed, often with hypercholesterolemia and transitory edema as well. " 01/01/2000 - "The analysis of early postoperative complications has established, that it a reasonable to perform such operations 1-3 years after gastroplasty when body weight stabilizes and there are no vitamin deficiency, iron deficient anemia, hypoproteinemia, hydroionic disturbances or other complications of the later period. " 10/31/1945 - "Maximal figures for new hemoglobin plus plasma protein production in anemia and hypoproteinemia using iron given intravenously, may reach 1.5 gm. "
5.	Serum AlbuminIBA 05/01/2009 - "(6) Eight women in the study group and one in the control group suffered from hypoproteinemia before SPE onset with the average level of plasma albumin of (32.6 +/- 1.6) g/L and (38.4 +/- 2.1) g/L (P < 0.01), respectively. " 04/01/2015 - "The patients were divided into mild, moderate and severe hypoproteinemia groups according to their serum albumin levels. " 11/01/2014 - "Serum albumin levels decreased in all groups during pregnancy, but hypoproteinemia was seen only after BPD. " 01/01/2013 - "Highly sensitive quantitation of human serum albumin in clinical samples for hypoproteinemia using metal-enhanced fluorescence." 04/15/2004 - "Of the 66 patients, 36 had hypoproteinemia (albumin concentration, 2.5 g per deciliter or less), and 30 had near-normal serum albumin concentrations (above 2.5 g per deciliter). "
6.	Methionine (L-Methionine)FDA Link 03/15/2001 - "On the contrary, vegetarians have deficits in methionine intake, and 15% of them have hypoproteinemia is (0% in omnivores). " 02/01/1950 - "Studies in methionine metabolism; the fate of intravenously administered S35-labeled-methionine in normal adult males, in patients with chronic hepatic disease, idiopathic hypoproteinemia and Cushing's syndrome." 01/01/2005 - "In subjects with predominant or exclusive consumption of plant food a higher incidence of hypoproteinemia due to significant reduction of methionine and lysine intakes was observed. " 02/01/1987 - "Unfavorable side effects of TPN with amino acid compound lacking L-methionine and L-cysteine were loss of body weight and development of hypoproteinemia. " 10/01/2005 - "NICCD patients have jaundice, hypoproteinemia, hypoglycemia, galactosemia, growth retardation, fatty liver and multiple aminoacidemia including citrulline, methionine, threonine and tyrosine. "
7.	Proteins (Proteins, Gene)IBA 11/01/2003 - "If there is a patient with severe hypoproteinemia and preserved levels of rapid turnover proteins, protein-losing gastroenteropathy should be suspected and we get a strong proof to do the following examinations such as a fecal clearance of alpha-1 antitrypsin." 12/01/1989 - "Because the plasma protein concentration (one of its components) is decreased in pregnancy, we decided to explore the question as to whether hypoproteinemia with intact protein mass (produced by blood volume expansion) or hypoproteinemia with decreased total protein mass (produced by removal of circulating proteins) alters the oncotic pressure differences across capillaries. " 04/01/1986 - "The osmotic reflection coefficient for total proteins was found to be 0.900 +/- 0.004 for hypoproteinemia conditions, which is equal to that found in a previous investigation for sheep with a normal plasma protein concentration. " 04/01/1986 - "Moreover, we estimated the average osmotic reflection coefficient for total proteins and the solvent drag reflection coefficients for the six protein fractions during hypoproteinemia. " 04/01/1986 - "We measured pulmonary arterial pressure, left atrial pressure, aortic pressure, central venous pressure, cardiac output, oncotic pressures of both plasma and lung lymph, lung lymph flow rate, and lung lymph-to-plasma ratio of total proteins and six protein fractions for both control base-line conditions and hypoproteinemia base-line conditions. "
8.	CreatinineIBA 06/01/2015 - "Serum chemistry revealed hypoproteinemia, hypocholesterolaemia, hypoglycemia, hyperbilirubinemia, elevated creatinine, BUN, increased AST and ALT. " 12/01/1996 - "The patients with pathologic X-ray findings had a more marked hypoproteinemia (lowest measured serum protein concentration 54 +/- 1 g/l) than those with normal X-ray (62.1 +/- 0.9 g/l, p < 0.001) and leukocytosis (highest measured blood leukocyte count 14.1 +/- 0.9 x 10(9)/l vs. 10.6 +/- 0.6 x 10(9)/l, p < 0.001) and more severe renal insufficiency (highest measured serum creatinine 590 +/- 60 mumol/l vs. 356 +/- 29 mumol/l, p < 0.05). " 01/01/1996 - "The STZ-induced diabetic rats showed nephropathy with proteinuria, hypoproteinemia, hyperlipidemia and reduced creatinine clearance. " 03/01/1983 - "Proteinuria, hypoproteinemia, hypercholesterolemia, and reduction in body weight were significantly greater in nephritic SHR than in nephritic SHR treated by AHD or nephritic WKYR, whereas BUN and serum creatinine were unchanged in all the nephritic rats. " 12/01/1997 - "Laboratory data showed accelerated erythrocyte sedimentation rate, proteinuria, microscopic hematuria, leukocytosis, hypoproteinemia, and elevated creatinine level. "
9.	Triglycerides (Triacylglycerol)IBA 02/01/1986 - "In spite of treatments with low-fat diet (medium-chain triglycerides), hyperalimentation, and abdominal paracentesis, hypoproteinemia and peripheral edema developed and symptomatic ascites continued. " 07/01/1993 - "An irregularly shaped nodular filling defect on selective jejunal films, severe hypoproteinemia, low IgG concentration, and lymphopenia were suggestive of primary intestinal lymphangiectasia with protein-losing enteropathy, and the patient was placed on a low-fat diet with medium-chain triglycerides. " 05/01/2009 - "All of the 39 cases were cured by treating with conservative individualized therapy, including the applying of diet with high calorie, high protein and low fat and fatty food should only contains medium-chain triglycerides, total parenteral nutrition, keep the balance of hydrogen and electrolyte and correct hypoproteinemia, local pressure dressing, high persistent vacuum drainage (-50 approximately -80 kPa) and/or somatostatin analogue. " 12/01/1984 - "Serum and urine chemical analysis revealed proteinuria and hypoalbuminemia in all animals tested; hypoproteinemia and high concentrations of serum cholesterol, triglycerides, and creatinine were detected in some of the affected hamsters. "
10.	Mercuric Chloride (Sublimate)IBA 12/01/1942 - "HYPOPROTEINEMIA AS PROTECTION AGAINST MERCURIC CHLORIDE INJURY IN DOGS." 12/01/1951 - "Hypoproteinemia as protection in mercuric chloride poisoning."

Therapies and Procedures

1.	Gastrectomy 07/01/1978 - "As a treatment for the diffuse type of Ménétrier's disease, subtotal gastrectomy was recommended by presenting enough recovery from hypoproteinemia. " 01/01/1967 - "[Syndrome of hypoproteinemia after partial gastrectomy]." 01/01/1947 - "[Prophylaxis of hypoproteinemia in the immediate postoperative period after sub-total gastrectomy: transgastric jejunal feeding]." 10/01/2013 - "The patient underwent a laparoscopy-assisted total gastrectomy, and her anemia and hypoproteinemia improved. " 10/01/1949 - "Gastric hyperchlorhydria with three primary jejunal ulcers and hypoproteinemia; report of a case relieved by total gastrectomy after subtotal gastric resection had proved inadequate."
2.	Plasmapheresis 01/01/1993 - "To determine whether hypoproteinemia slows the rate at which liquid is cleared from the lung lumen, we studied 36 lambs, 18 of which underwent repeated plasmapheresis, reducing plasma protein concentration by 37% and plasma protein osmotic pressure by 39%. " 07/01/1992 - "To induce hypoproteinemia, we subjected each animal to 3 days of batch plasmapheresis (6 units per day). " 02/01/1986 - "Effects of plasmapheresis and of hypoproteinemia on lung liquid conductance in awake sheep." 07/01/1950 - "Effect of hypoproteinemia produced by plasmapheresis on plasma and interstitial fluid volumes and renal clearances of dogs." 10/31/1945 - "Maximal output for plasma protein alone in hypoproteinemia due to plasmapheresis reaches 60 to 70 gm. "
3.	Total Parenteral Nutrition 01/01/2002 - "Following 5 weeks of total parenteral nutrition, his symptoms and hypoproteinemia improved and he was discharged, although follow-up colonoscopic findings revealed no improvement. " 09/01/1994 - "Despite tube thoracostomies and the initiation of total parenteral nutrition, massive losses of chyle persisted, resulting in hypoproteinemia and severe lymphopenia. " 01/01/1982 - "Tube feeding with an elemental or a low residue diet and total parenteral nutrition were prescribed to treat the hypoproteinemia and anemia. " 01/01/1979 - "In addition, parenteral hyperalimentation and Rheomacrodex-Sorbit may be indicated, but the hypoproteinemia should at any rate be corrected." 10/01/1999 - "The most significant metabolic/nutritional complication was the appearance of hypoproteinemia (hypoalbuminemia) in 1 distal RYGB patient 20 months after surgery, which was corrected by total parenteral nutrition and subsequent increase in dietary protein intake. "
4.	Renal Dialysis (Hemodialysis) 02/01/2005 - "[Coronary artery bypass grafting in patients undergoing chronic hemodialysis: importance of wound healing and hypoproteinemia]." 01/01/1993 - "These data suggest that hemodialysis or end-stage renal disease itself, rather than hypoproteinemia, may hold the key to high serum Lp(a) levels in hemodialysis patients." 09/01/2010 - "The key aspects of treatment success achievement and improved quality of life in patients on programmed hemodialysis are the detection of cardiovascular diseases requiring surgery, the timely referral of the patients to a cardiosurgical hospital, the meticulous pre- and perioperative management (correction of anemia, hypoproteinemia, water-electrolyte balance, use of ultrafiltration and the adequate rate of perfusion at the stage of extracorporeal circulation, and daily renal replacement therapy in the postoperative period), and continuity in the work of all specialists." 03/01/2003 - "We have suggested that r-hGH and IGF-1 improve the malnutritional state by alleviating hypoproteinemia and abnormality of serum amino acid profile in uremic patients on hemodialysis. " 01/01/1997 - "We conclude that r-hGH and IGF-I improve the malnutritional state by alleviating hypoproteinemia and abnormality of serum amino acid profile in uremic patients on hemodialysis. "
5.	Extracorporeal Circulation 02/01/1981 - "[Preparation of the nursing standard for patients undergoing extracorporeal circulation and open heart surgery without the use of transfused blood--toward improvement of anemia and hypoproteinemia]." 09/01/2010 - "The key aspects of treatment success achievement and improved quality of life in patients on programmed hemodialysis are the detection of cardiovascular diseases requiring surgery, the timely referral of the patients to a cardiosurgical hospital, the meticulous pre- and perioperative management (correction of anemia, hypoproteinemia, water-electrolyte balance, use of ultrafiltration and the adequate rate of perfusion at the stage of extracorporeal circulation, and daily renal replacement therapy in the postoperative period), and continuity in the work of all specialists."