Hypoglycemic Agents (Hypoglycemics)

Substances which lower blood glucose levels.

Also Known As:

Hypoglycemics; Antidiabetic Agents; Antidiabetic Drugs; Antihyperglycemic Agents; Antihyperglycemics; Hypoglycemic Drugs; Hypoglycemic Effect; Hypoglycemic Effects; Agent, Antidiabetic; Agent, Antihyperglycemic; Agent, Hypoglycemic; Agents, Antidiabetic; Agents, Antihyperglycemic; Agents, Hypoglycemic; Drug, Antidiabetic; Drug, Hypoglycemic; Drugs, Antidiabetic; Drugs, Hypoglycemic; Effect, Hypoglycemic; Effects, Hypoglycemic; Antidiabetic; Antidiabetic Agent; Antidiabetic Drug; Antidiabetics; Antihyperglycemic; Antihyperglycemic Agent; Hypoglycemic; Hypoglycemic Agent; Hypoglycemic Drug

Networked: 14973 relevant articles (936 outcomes, 2201 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Physiological Effects of Drugs: 1
    - Hypoglycemic Agents: 14973

Experts

1.	Ji, Linong: 27 articles (06/2022 - 09/2011)
2.	Sahebkar, Amirhossein: 26 articles (02/2022 - 10/2018)
3.	Kaku, Kohei: 25 articles (01/2022 - 01/2009)
4.	Kadowaki, Takashi: 22 articles (11/2020 - 12/2003)
5.	Scheen, A J: 21 articles (05/2020 - 05/2001)
6.	Blonde, Lawrence: 20 articles (11/2020 - 04/2004)
7.	Seino, Yutaka: 19 articles (11/2020 - 12/2004)
8.	Inzucchi, Silvio E: 18 articles (01/2022 - 01/2002)
9.	Watada, Hirotaka: 18 articles (01/2022 - 08/2004)
10.	Rosenstock, Julio: 18 articles (06/2021 - 10/2004)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 01/01/2018 - "Oral hypoglycemic agents (OHAs) are highly effective in managing Type 2 diabetes if taken appropriately. " 03/01/2013 - "Noninsulin antidiabetic medications coupled with diet and exercise are effective in managing most patients with type 2 diabetes. " 06/01/1998 - "The short-term IIT in patients with NIDDM and secondary failure to SU is effective in reducing hyperglycaemia, and in most of them makes possible to continue the oral antidiabetic treatment with SU. " 10/26/2021 - "Dipeptidyl peptidase-4 (DPP-4) inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus (T2DM). " 03/01/2019 - "Based on the findings presented here, it has been concluded that TPSE has marked antidiabetic effects through various pathways on STZ/NA-induced diabetic rats and it may potentially be used as an effective treatment for type 2 diabetes mellitus (T2DM). "
2.	Insulin Resistance 10/01/2018 - "MeMC possesses potent antidiabetic activity and ameliorates insulin resistance in HFD diet fed C57 mice." 02/01/2018 - "After complete resection of the tumour and remission of hypoglycemic episodes, insulin sensitivity increased in all evaluated subjects (72.8±36.7%) and normalized in the majority. " 12/07/2016 - "These findings showed that the viable probiotic more effectively relieved hypoglycemic symptoms in the host by ameliorating insulin resistance. " 01/01/2018 - "The present results show that Purslane has pancreas protective effects via its hypoglycemic and insulin resistance reducing activity." 01/01/2009 - "[Could oral antidiabetic agents be useful in the management of different types of diabetes and syndromes of insulin resistance in children and adolescents?]."
3.	Hypoglycemia (Reactive Hypoglycemia) 07/01/2018 - "In MICU hyperglycemic patients, the simple, intuitive and economical "BBC200" protocol could lead to a hypoglycemic risk very close to zero (0.24%), with a significant reduction in hypoglycemia-related clinical events and a modest increase in persistent hyperglycemic phenomena." 09/09/2010 - "A potent and selective GPR40 agonist is theorized to be a safe and effective antidiabetic drug with little or no risk of hypoglycemia. " 03/23/2015 - "The significant reduction in nocturnal time spent in a hypoglycemic state observed during this study suggests that a longer term study of CGM use, especially nocturnal use, could be beneficial for patients with hypoglycemia unawareness." 08/01/2013 - "In the ED stratum, there was a reduction in hypoglycemic events in the 4 wk prior to study end from baseline (mean reduction of 2.46 events, not significant) and a significant reduction in nocturnal hypoglycemia (mean reduction of 2.24 events, p = 0.0078). " 07/01/2011 - "This is especially true in short-term studies designed to reduce hypoglycemia since the event rate for severe hypoglycemic events is too low for it to be a good outcome, and milder hypoglycemia often will be variably detected. "
4.	Hyperglycemia 06/01/2017 - "Although current antidiabetic drugs are highly effective for the management of hyperglycemia, most T2DM patients remain exposed to a substantial and concrete risk of CVD. " 01/01/2017 - "Although current antidiabetic drugs are highly effective for the management of hyperglycemia, most T2DM patients remain exposed to a substantial and concrete risk of CVD. " 03/01/2000 - "The hypoglycemic action of Compound Hypoglycemic Decoction was remarkable in clinical practice, and it is very effective in preventing hyperglycemia in experimental mice." 04/01/2019 - "Overall Rheum spiciformis showed ameliorative action on oxidative stress and hyperglycemia, however further studies to explore the mechanism of action of possible therapeutic compound in invivo clinical trials will prove beneficial for the advancement of new oral antidiabetic drug." 01/01/2018 - "Conclusion: The results of our study show the hypoglycemic impact of black truffle on STZ-induced hyperglycemia in rats via Nrf2 and NF-κB pathways, and both pathways have significant improvement that may support the hypoglycemic impact of truffle."
5.	Body Weight (Weight, Body) 04/01/2014 - "Chronic treatment with FXE at 100 mg per kg body weight per day, a dose equivalent to that showing hypoglycemic activity in humans, resulted in a significant decrease in glycemia (-16.3%), triglyceridemia (-33.4%) and body weight (-8.1%) in Zucker rats as well as a significant decrease in SBP in SHR (-6.7%), with a concomitant improvement in endothelial function in both strains. " 01/01/2023 - "This study's results showed that GLP-1RAs were effective in lowering HbA1c and reducing body weight without increased incidence of hypoglycemic reactions. " 10/01/2012 - "These studies have indicated that, in addition to decreasing body weight and improving glycemia, LCKD can be effective in decreasing antidiabetic medication dosage. " 01/01/2021 - "In vivo study revealed dose-dependent hypoglycemic effect and body weight improvement in rats treated with the AESTL. " 01/01/2011 - "In contrast to other antidiabetic treatments, these agents have a positive outcome profile on body weight. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Metformin (Glucophage)
4.	Antioxidants
5.	Blood Glucose (Blood Sugar)
6.	Insulin Glargine (Lantus)
7.	Hypoglycemic Agents (Hypoglycemics)
8.	Sodium-Glucose Transporter 2 Inhibitors
9.	Lipids
10.	Antihypertensive Agents (Antihypertensives)

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Bariatric Surgery
4.	Transplantation
5.	Gastrectomy