Hypertrichosis

Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.

Also Known As:

Networked: 422 relevant articles (11 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Hirsutism
3.	Nevus (Nevi)
4.	Gingival Hyperplasia
5.	Acanthosis Nigricans

Experts

1.	Paus, R: 3 articles (06/2015 - 07/2012)
2.	Kutsche, Kerstin: 3 articles (06/2015 - 01/2007)
3.	Christiano, Angela M: 3 articles (05/2013 - 11/2008)
4.	Newfield, Ron S: 2 articles (12/2015 - 01/2014)
5.	Brownstein, Catherine A: 2 articles (09/2015 - 12/2013)
6.	Leuzzi, Vincenzo: 2 articles (06/2015 - 10/2013)
7.	Pizzuti, Antonio: 2 articles (06/2015 - 10/2013)
8.	White, Susan M: 2 articles (06/2015 - 01/2014)
9.	Campeau, Philippe M: 2 articles (06/2015 - 12/2013)
10.	Grammatico, Paola: 2 articles (06/2015 - 10/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertrichosis:

1.	Tacrolimus (Prograf)FDA LinkGeneric 07/01/1994 - "Although hypertrichosis is induced by both topical and oral administration of CsA, there has been no report showing that FK506 induces hypertrichosis. " 01/01/2005 - "Focal hypertrichosis during topical tacrolimus therapy for childhood vitiligo." 08/01/2002 - "This paper describes our experience with tacrolimus conversion from cyclosporine-based therapy in six selected cases: four due to refractory acute rejections unresponsive to conventional therapy, one to chronic graft rejection, and one to cyclosporine-related hypertrichosis. " 06/01/1998 - "Elective conversion of patients from cyclosporine to tacrolimus for hypertrichosis." 01/01/2007 - "The prevalence of hypomagnesemia was higher in the tacrolimus group whereas hypertrichosis and gingival hyperplasia occurred more frequently in the cyclosporine group. "
2.	Androgen Antagonists (Antiandrogens)IBA 05/01/2002 - "Although frequently used, systemic antiandrogens have not yet proven their efficacy against unwanted hypertrichosis in clinical studies using modern and objective endpoints. "
3.	Minoxidil (Rogaine)FDA LinkGeneric 09/01/2015 - "Generalized Hypertrichosis Due to Topical Minoxidil." 07/01/2014 - "A 9-month-old girl exposed to 5% topical minoxidil for 2 months developed generalized hypertrichosis of the exposed and unexposed areas of her body. " 01/01/2014 - "Minoxidil induced hypertrichosis in children." 08/01/2013 - "Hypertrichosis is a well-recognized adverse effect of therapy with either oral or topical minoxidil. " 01/01/2013 - "Minoxidil induced hypertrichosis in a 2 year-old child."
4.	Thyroxine (Levothyroxine)FDA LinkGeneric 04/01/2006 - "The hypertrichosis resolved after 3 months' of thyroxine replacement treatment. " 09/01/1986 - "Remission of acanthosis nigricans, hypertrichosis, and Hashimoto's thyroiditis with thyroxine replacement." 09/01/2005 - "Acquired ichthyosis and hypertrichosis due to autoimmune thyroiditis: therapeutic response to thyroxine replacement." 08/01/1985 - "A 10 year old girl with hypertrichosis associated with primary hypothyroidism that resolved after 6 months' replacement treatment with thyroxine is reported. "
5.	CholesterolIBA 06/01/2015 - "Clinically, pharmacological modulation of the activity of selected intrafollicular ABC transporters may permit novel therapeutic interventions, such as protecting HF stem cells from chemotherapy-induced damage, counteracting cholesterol-associated hypertrichosis, and manipulating the intrafollicular prostaglandin balance in androgenetic alopecia." 05/01/2005 - "After the switch to tacrolimus, mean total cholesterol was reduced by 15% at month 6. One hundred seventy-seven additional patients were switched primarily for other indications: hypertrichosis, gingival hyperplasia, and arterial hypertension, and these symptoms also improved after the switch. "
6.	Prednisolone (Predate)FDA LinkGeneric 11/01/2006 - "Chemotherapy was then switched to cyclophosphamide and prednisolone, resulting in further improvement in muscle power and hypertrichosis. "
7.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/01/2006 - "Chemotherapy was then switched to cyclophosphamide and prednisolone, resulting in further improvement in muscle power and hypertrichosis. "
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 09/01/2012 - "Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. " 04/01/2011 - "A range of pilosebaceous unit disorders were observed with hypertrichosis being strongly associated with ciclosporin (P<0.0001). " 12/01/2007 - "There was no correlation between ciclosporin exposure or duration and hypertrichosis. " 06/01/2003 - "One of the most common side effects of treatment with cyclosporin A (CsA) is hypertrichosis. " 04/01/1997 - "A constant dose-dependent side-effect in cyclosporin A (CSA)-treated patients is the appearance of hypertrichosis; this occurs in both sexes and suggests an androgenizing activity. "
9.	HormonesIBA 11/01/1967 - "(Clinical study, hormone elimination and colpocytological aspects in some cases of hypertrichosis)]." 09/01/1995 - "The purpose of this article is to show that abnormal hair-growth associated with malignancy (acquired hypertrichosis) is probably caused by a peptide hormone which remains to be detected by examining serum, skin, and tumour specimens of affected patients. " 05/01/1995 - "Other cases of hypertrichosis, including ectopic hormone production, were excluded and the differential diagnosis with paraneoplastic acquired hypertrichosis lanuginosa is discussed. " 01/01/1987 - "The development of hypertrichosis during CyA administration is not hormone-dependent; it may be mediated by a direct effect of the drug on the hair growth process. " 09/01/1986 - "Both AN and hypertrichosis resolved with thyroid hormone replacement. "
10.	Diazoxide (Hyperstat)FDA Link 04/11/1968 - "Hypertrichosis lanuginosa associated with diazoxide therapy in prepubertal children: a clinicopathologic study." 12/01/2015 - "Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth." 01/01/2015 - "A 15-year-old girl with diazoxide-responsive CHI had severe hypertrichosis secondary to diazoxide and subsequent compliance/psychosocial issues. " 01/01/2014 - "Despite frequent feeds, she required treatment again between ages 4-6.5 years, initially with diazoxide but due to severe hypertrichosis she was switched to LAR with an excellent response. " 03/01/2013 - "Acquired generalized hypertrichosis due to diazoxide."

Therapies and Procedures

1.	Lasers (Laser) 02/01/2000 - "Laser pulses which selectively damage pigmented hair follicles are a useful treatment for hypertrichosis. " 09/01/1999 - "Laser technologies have improved over recent years, bringing new opportunities for efficacious treatment of hypertrichosis. " 01/01/2011 - "In addition to lasers, intense pulsed light (IPL) sources are widely used in medicine to treat various indications, such as vascular lesions, irregular pigmentation and hypertrichosis. " 07/01/2005 - "All cases of laser-induced hypertrichosis were assessed clinically by history, examination, and laboratory tests, and confirmed by review of serial clinical photographs taken during the course of the laser treatments. " 03/01/2010 - "Paradoxical hypertrichosis is a rare side effect of laser hair removal; the pathogenesis of this event remains widely unknown. "
2.	Hair Removal (Depilation) 04/02/2014 - "Furthermore, hair removal of congenital and acquired hypertrichosis can relieve psychosocial discomfort and improve quality of life. " 12/01/2013 - "Successful ablation of iatrogenic intraoral hypertrichosis post mandibular reconstruction using a thermolysis hair epilation technique." 03/01/2012 - "We report a case of 1-year-old girl with congenital hypertrichosis terminalis treated using intense pulsed light for hair removal. " 03/01/2012 - "Intense pulsed light hair removal in a patient with congenital hypertrichosis terminalis." 01/01/2009 - "Paradoxical hypertrichosis and terminal hair change after intense pulsed light hair removal therapy."
3.	Solid-State Lasers 03/01/2000 - "The long-pulsed alexandrite laser at a pulse duration of 20 msec is an effective and safe method of treatment of hypertrichosis in the facial region of women. " 08/01/2008 - "With the alexandrite laser Arion (755 nm), 13 treatments for hypertrichosis were evaluated. " 07/01/2004 - "Naevoid hypertrichosis treated with alexandrite laser." 01/01/2003 - "Lumbosacral hypertrichosis treated with the normal-mode ruby laser." 03/01/2000 - "In the retrospective study on hand, we report on results of 30 female patients with hypertrichosis in the facial area treated with the long pulse alexandrite laser at 20 msec (Cynosure PhotoGenica LPIR/Apogee; 755 nm; 20 msec; up to 30 J/cm2; 10 or 12.5 mm beam diameter) over an 18 month treatment period. "
4.	Semiconductor Lasers 01/01/2015 - "The purpose of this case report is to describe a diode laser resection of gingival hyperplasia in a seven-year-old patient with nonsyndromic HGF and hypertrichosis. " 01/01/2014 - "The study supports the use of low fluence with high-repetition-rate diode laser hair removal as a safe and effective method for the management of hypertrichosis in Becker's nevus."
5.	Drug Therapy (Chemotherapy) 07/01/1992 - "Hypertrichosis lanuginosa acquisita following cytotoxic chemotherapy." 07/01/1983 - "Florid scalp hair regrowth following the depilatory effects of both whole cranial radiotherapy and cytotoxic chemotherapy is described in a patient who simultaneously exhibited acquired hypertrichosis lanuginosa in the head and neck region. " 01/01/2011 - "Here, we describe a patient with localized hypertrichosis of the pinnae that occurred 4 months after orchiectomy and chemotherapy for a testicular carcinoma. " 01/01/2011 - "Hairy pinnae after orchiectomy and chemotherapy for testicular cancer: acquired localized hypertrichosis of the ears." 11/01/2001 - "The following report is about a mentally retarded patient who has shown no sign of hypertrichosis, but has been taking phenobarbital as a long-term therapy drug for anti-convulsion. "