Hypertonic Solutions

01/01/2012 - "There is a wealth of preclinical data suggesting potential benefit from the administration of hypertonic solutions after severe injury with hypovolemic shock, including improved tissue perfusion, improved flow through the microcirculation, and modulation of the inflammatory response, which may mitigate subsequent organ failure. "
04/01/1992 - "Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room."
07/01/2015 - "At clinical dilutions equivalent to those generally administered for shock (saline 1:3, HES 1:9, and hypertonic solutions 1:22), CTPFA was more prolonged by HH and HTS than other solutions but more by saline than HES. "
04/15/2003 - "Hypertonic solutions are useful for the management of hypovolemic shock but cause impairment in platelet function. "
05/01/2002 - "Hypertonic solutions have been studied extensively in the treatment of hypovolemic shock, both in experimental and clinical models. "

02/10/2012 - "Hypertonic solutions are mainstay of osmotherapy to cerebral edema. "
02/10/2012 - "Bolus injection of hypertonic solutions for cerebral edema in rats: challenge of homeostasis of healthy brain."
01/01/1957 - "The treatment of experimental cerebral edema by intravenous hypertonic solutions."
01/01/2013 - "Hypotonic solutions are contraindicated in (impending) cerebral edema, whereas hypertonic solutions are probably more helpful in ameliorating than in preventing this condition and improving outcome. "
10/01/1965 - "[Electron microscopic study of brain edema with reference to the effects of hypertonic solutions and a steroid hormone]."

05/01/2004 - "Although showing some promising results, the importance of hypertonic solutions for volume replacement in the trauma patient is not yet defined. "
07/01/2015 - "This study explores the impact of resuscitation with various hypertonic solutions on early coagulopathy after trauma. "
04/01/1989 - "There has recently been an increased interest in the use of hypertonic solutions for fluid resuscitation of trauma victims. "
06/01/2006 - "Hypertonic solutions promote immediate blood volume expansion, restore cardiac output and regional blood flows, improve microcirculation and modulate immune responses, thereby decreasing inflammatory responses triggered by shock and trauma. "
08/01/1995 - "Resuscitation with tiny volumes of hypertonic solutions rapidly restores tissue perfusion while minimizing edema after hemorrhage and tissue trauma. "

09/01/2006 - "All four hypertonic solutions initially improved MAP, which, by 120 min after infusion, had decreased nearly to the levels observed during hemorrhage. "
10/01/1995 - "Using a standardized liver injury model of uncontrolled hemorrhage, we tested the effect of different hypertonic solutions on mortality, blood pressure, intra-abdominal bleeding, and circulating blood volume. "
08/01/1993 - "Isochloremic hypertonic solutions for severe hemorrhage."
10/01/1990 - "Despite the normalization of cardiac output by small volumes of hypertonic solutions, 7.2% saline alone failed to fully restore RBF after protracted traumatic hemorrhage. "
10/01/1982 - "Acute and intense hemorrhage in the anterior lobe of the pituitary was observed in mice treated with hypertonic solutions. "

01/01/2005 - "In patients with severe head trauma (SHT), application of hypertonic solutions is possible; long term outcome, however, is not improved by this measure. "
07/01/1994 - "Appropriate fluid therapy after head injury requires avoidance of sugar-containing solutions, maintenance of normovolaemia and consideration of use of hypertonic solutions to maintain vascular volume. "
09/28/1996 - "Therefore, in the presence of patients with head injury and especially hemorrhagic shock, it is essential to ensure a cerebral perfusion pressure (CPP) of > 80 mm Hg. Hypertonic solutions have gained popularity in these clinical situations because of their combined effects on ICP, mean arterial pressure (MAP) and CPP. "
09/28/1996 - "The use of hypertonic solutions (Ringer lactate or NaCl) for intravascular fluid resuscitation of patients suffering from hypovolemic head trauma has gained popularity. "