Portal Hypertension

07/01/1999 - "The purpose of this study was to evaluate safety and efficacy of propranolol in the management of portal hypertension in the pediatric population. "
09/01/1991 - "Early chronic administration of propranolol reduces the severity of portal hypertension and portal-systemic shunts in conscious portal vein stenosed rats."
12/01/2007 - "We conducted this study to determine the effect of propranolol on portal hypertension and the optimal required dose in Korean cirrhotic patients. "
03/01/2003 - "The study was initiated in 53 patients with portal hypertension, of whom 14 were withdrawn because of adverse effects of propranolol. "
09/01/1990 - "This study investigated the effects of propranolol, a drug widely used in the treatment of portal hypertension, on gastric mucosal blood flow and acid secretion in portal hypertensive rats with partial portal vein occlusion. "

04/01/1993 - "We conclude that SMS 201-995 is useful for the treatment of portal hypertension because of its effect of reducing portal pressure with mild changes in systemic hemodynamics. "
04/01/2012 - "Randomised clinical trial: the safety and efficacy of long-acting octreotide in patients with portal hypertension."
09/01/2008 - "This study provides the first experimental evidence showing that octreotide may be an effective anti-angiogenic therapy early after induction of portal hypertension, but not in advanced stages most likely due to SSTR2 down-regulation during the progression of portal hypertension in rats. "
11/01/1996 - "The aim of the present study was to investigate whether chronic administration of octreotide can increase vascular responsiveness in rats with portal hypertension. "
11/01/1992 - "Octreotide inhibits the meal-induced increases in the portal venous pressure of cirrhotic patients with portal hypertension: a double-blind, placebo-controlled study."

01/01/2005 - "Our study demonstrates that increased ET and nitric oxide metabolism is associated with the hemodynamic alterations induced by portal hypertension."
11/01/2002 - "This study demonstrated that the increased nitric oxide metabolism is associated with the haemodynamic alterations induced by portal hypertension."
01/01/1994 - "Recent experimental studies have suggested that an increase in the synthesis of nitric oxide, a powerful vasodilator secreted by endothelial cells, plays a role in the hemodynamic disturbances associated to portal hypertension. "
03/21/2013 - "Current concepts on the role of nitric oxide in portal hypertension."
05/01/2012 - "It can also augment nitric oxide (NO) production, which plays a crucial role in the pathogenesis of portal hypertension and modulation of porto-systemic collaterals. "

09/01/2001 - "These findings suggest the existence of a vasoconstrictor territorial selectivity for vasopressin and its analogues, which could justify the efficacy of these drugs in portal hypertension therapy. "
09/01/2001 - "F-180 has been proposed as a new vasopressin analogue for the treatment of portal hypertension. "
11/01/1995 - "Response of blood flow to vasopressin in the collateral left gastric vein in patients with portal hypertension."
07/01/1991 - "Effects of vasopressin on gastric mucosal blood flow in portal hypertension."
04/01/1991 - "Ten to twelve days after the induction of chronic portal hypertension, the responsiveness of the small intestinal circulation to cumulative doses of vasopressin was evaluated using an isolated pump-perfused small intestinal preparation. "

07/01/2013 - "This study aims to compare the effects of bolus and continuous infusion of terlipressin on systemic and hepatic hemodynamics in patients with portal hypertension. "
03/01/1997 - "This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal-pressure and collateral blood flow of reduced doses, suitable for longer therapy to prevent early rebleeding. "
01/01/1993 - "This study suggests that terlipressin might further reduce portal pressure in patients with portal hypertension treated with beta-blockers."
07/01/2013 - "The hemodynamics of patients with portal hypertension within 4 h after a single injection of terlipressin has been studied. "
07/01/2013 - "Hemodynamic effects of continuous versus bolus infusion of terlipressin for portal hypertension: a randomized comparison."

08/15/2003 - "Despite universal use of somatostatin, the cellular and biochemical mechanisms of its effects in portal hypertension are relatively poorly studied and remain incompletely understood. "
08/15/2003 - "Pharmacological rationale for the use of somatostatin and analogues in portal hypertension."
06/01/2002 - "Somatostatin and analogues in portal hypertension."
09/01/1999 - "Somatostatin and its analogue have been shown to provide beneficial effects in the management of portal hypertension and hyperdynamic circulation. "
09/01/1995 - "The significant reductions of gastric mucosal ISO2 and IHB by somatostatin support the hypothesis that somatostatin is capable of attenuating the hyperdynamic circulatory state in the gastric mucosa of rats with portal hypertension and may have a beneficial effect on portal hypertensive gastropathy. "

11/01/2006 - "Total serum bilirubin level of greater than 1.2 mg/dL and portal hypertension at diagnosis jointly predicted a significant delay in remission. "
11/01/1996 - "Thus, of the 64 patients left for study, 38 had a good result with respect to serum bilirubin level, but 18 of them still have symptoms of portal hypertension. "
09/01/2015 - "Patients with portal hypertension had lower platelet counts and albumin levels, while bilirubin levels, INR, MELD and Child-Pugh scores were higher than in patients without portal hypertension. "
08/01/2015 - "For all resected patients (A+C), portal hypertension and bilirubin >1 mg/dL were not associated with mortality. "
06/01/2014 - "Liver resection should be considered for patients with well-preserved liver function and without portal hypertension or elevated bilirubin. "

03/01/2005 - "Losartan, a dose of 25 mg/day, has been found to be effective in 50% of patients with portal hypertension without adverse effects. "
04/01/2010 - "Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats."
11/01/2003 - "Low doses of losartan reduce portal hypertension by an increase in splanchnic vascular resistance without hypotensive side-effects on arterial pressure."
01/01/2003 - "Five out of eight patients who respond to losartan showed severe portal hypertension, with higher baseline HVPG (equal or greater than 16 mmHg). "
05/01/2002 - "Effect of 1-week losartan administration on bile duct-ligated cirrhotic rats with portal hypertension."

11/01/1989 - "The results indicate that, in patients with portal hypertension, an improvement in haemodynamics can be achieved by the use of isosorbide dinitrate. "
01/01/1986 - "Isosorbide dinitrate in experimental portal hypertension: a study of factors that modulate the hemodynamic response."
04/01/1990 - "We studied over 20 minutes the effect of 10 mg isosorbide dinitrate sublingual on intrasplenic pulp pressure, mean arterial pressure and heart rate, in 13 patients with cirrhotic or non-cirrhotic portal hypertension. "
04/01/1990 - "Effect of sublingual isosorbide dinitrate in portal hypertension."
07/01/1988 - "Effect of sublingual isosorbide dinitrate on wedged hepatic venous pressure in cirrhotics with portal hypertension."

03/01/2000 - "Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension."
10/01/2005 - "In our study, rats with prehepatic portal hypertension developed hippocampal mitochondrial dysfunction as indicated by decreased respiratory rates, respiratory control and mitochondrial nitric oxide synthase (mtNOS) activity in mitochondria isolated from the whole hippocampus. "
10/01/2000 - "The aim of this study was therefore to investigate whether or not the inhibitor of NO synthase (NOS) might improve portal hypertension, and also to clarify the relationship between NO and ET-1. "
05/01/1995 - "The aim of the study was to investigate whether inducible NO synthase is expressed in portal hypertension an accounts for the hyperdynamic circulation. "
04/01/2015 - "Portal hypertension results from endothelial dysfunction after liver injury caused in part by abnormal production of endothelial cell derived nitric oxide synthase (eNOS). "

04/01/2011 - "The transjugular intrahepatic portosystemic shunt (TIPS) is widely used for the treatment of portal hypertension in adults, but no studies have defined the best approach to treat portal hypertension in pediatric patients. "
03/01/2015 - "The transjugular intrahepatic portosystemic shunt (TIPS) is effective for treating complications of portal hypertension in cirrhotic adults but the experience in children is limited. "
01/01/2013 - "Transjugular intrahepatic portosystemic shunt (TIPS) is an established and effective treatment for the complications of portal hypertension. "
02/01/2008 - "Transjugular intrahepatic portosystemic shunt (TIPS), which reduces portal pressure and decreases the sympathetic drive associated with portal hypertension, is effective in improving renal function. "
07/01/2005 - "Transjugular intrahepatic portosystemic shunt (TIPS) has become an effective treatment for the complications of portal hypertension. "

07/01/1986 - "Isolated obstruction of the splenic vein leads to segmental portal hypertension, which is a rare form of extrahepatic portal hypertension, but it is important to diagnose, since it can be cured by splenectomy. "
01/01/2004 - "Esophagogastric devascularization and splenectomy promote a significant reduction of the elevated portal pressure and flow in schistosomal portal hypertension. "
06/01/2015 - "Esophagogastric devascularization without splenectomy in portal hypertension: safe and effective?"
01/01/2015 - "Long-term efficacy of subtotal splenectomy due to portal hypertension in cirrhotic patients."
09/01/2000 - "To review our experiences in and evaluate the efficacy of pericardial devascularization with splenectomy for the treatment of portal hypertension. "

02/01/2012 - "Liver transplantation was strikingly effective for treating the clinical symptoms attributable to portal hypertension. "
01/01/1994 - "We therefore conclude that this method is a safe and effective therapy for complications of portal hypertension, in patients referred for liver transplantation."
09/01/2015 - "The outcomes of liver resection were improved while liver transplantation was performed for the patients with suspicious portal hypertension. "
04/01/2013 - "One patient required liver transplantation for de novo symptoms of portal hypertension 4 years after primary symptoms had been cured by HAE. "
02/01/2015 - "The aim of this study was to investigate changes to spleen stiffness after orthotopic liver transplantation (OLT) when portal hypertension resolves. "

05/01/2009 - "PV stent placement is safe, with an acceptable success rate, and provides symptomatic relief from the sequelae of presinusoidal portal hypertension."
07/01/2001 - "Stent placement helped to relieve portal hypertension symptoms. "
12/01/2000 - "Immediately after stent placement, the stenotic lesion was effectively dilated, the portal blood flow restored, and portal hypertension relieved. "
03/01/1993 - "Repeat dilatation and placement of a coaxial Palmaz stent again relieved portal hypertension. "
05/04/2010 - "[Percutaneous retroperitoneal splenorenal stent shunt:an experimental study in swine model with portal hypertension]."

07/29/1990 - "Thus this technique may improve the control of the efficacy of sclerotherapy in patients with portal hypertension. "
11/01/2012 - "To study the rates of variceal recurrence and rebleeding following sclerotherapy and its effect on clinical and laboratory parameters in patients with portal hypertension. "
08/01/2004 - "The present study aimed to study the long-term effect of endoscopic sclerotherapy in children with portal hypertension. "
07/01/1997 - "Study of portal hypertension in children with special reference to sclerotherapy."
03/01/1994 - "Unlike most surgical procedures for portal hypertension, the technique of performing sclerotherapy is not standardized, making the comparison of controlled trials difficult. "