Hyperphagia

02/01/1997 - "In our previous study, making ventromedial hypothalamic (VMH) lesions in GK rats induced hyperphagia and a further deterioration in glucose metabolism. "
05/15/2015 - "Chronic overeating impairs hepatic glucose uptake and disposition."
10/01/2011 - "Strategies that temper postprandial reductions in glucose levels might reduce the risk of overeating, particularly in environments inundated with visual cues of high-calorie foods."
10/01/2009 - "This model is characterized by glucose redistribution from skeletal muscle to adipose tissue during catch-up fat that results solely from suppressed thermogenesis (i.e., without hyperphagia). "
04/01/2006 - "Furthermore, inactivation of these glucose sensors causes overeating."

10/01/2013 - "We conclude that individual insulin reactivity is critical to reduce food-cue responsivity after an initial energy intake and thereby may help to counteract overeating."
07/01/2009 - "To our knowledge this study is the first to investigate insulin signaling during overeating in humans, and it demonstrates that T2D effects on intracellular insulin signaling already occur after 4 wks of a high-calorie diet and that the effects in humans differ from those in laboratory animals."
09/01/1983 - "To evaluate the role of insulin as an effector of hyperphagia and fattening in dormice, experiments were conducted to study pancreatic function and adipose tissue metabolism during several phases of the infradian cycle. "
01/01/2014 - "Interestingly in the pair-fed ZL and ZF rats, transient overeating on the last day of pair-feeding regimen changes the expression levels of some VA catabolic genes, and impairs the insulin- and RA-regulated gene expression in hepatocytes. "
11/01/2013 - "One-fourth of girls with type 1 diabetes scored above the cutoff for DEB and one-third reported skipping their insulin dose entirely at least occasionally after overeating. "

07/01/2009 - "In fact, intracerebroventricular administration of melanocortin agonist, MT-II in mice robustly overcomes high-fat diet-induced leptin resistance and ameliorates fuel dyshomeostasis and hyperphagia, with a concomitant recovery of AMPK activity in skeletal muscle. "
02/01/2009 - "Actually, intracerebroventricular administration of melanocortin agonist MT-II robustly overcomes high fat diet-induced leptin resistance and ameliorates fuel dyshomeostasis and hyperphagia in mice, with a concomitant recovery of AMPK activity in skeletal muscle, thereby highlighting the system as a therapeutic target for leptin resistance. "
06/01/2015 - "The detailed roles of leptin and other psycho-neuro-endocrinology factors in the mechanism of overeating among women with PMDD should be evaluated in future study."
07/01/2011 - "The present study aimed to examine whether the decreased circulating leptin level and/or hypothalamic leptin sensitivity contributed to the hyperphagia during lactation in Brandt's voles. "
10/01/2010 - "In conclusion, this study has presented new evidence that the hyperphagia of lactating rats could be partly due to depressed sensitivity of neurons contacting blood leptin. "

11/15/2012 - "Previously, we reported that overeating for only a few days markedly suppressed the secretion of growth hormone (GH). "
08/10/1996 - "In a distinctive subgroup (n = 29), growth-hormone insufficiency was associated with characteristic behavioural features, especially hyperphagia and polydipsia, and a normal body-mass index. "
08/10/1996 - "A new stress-related syndrome of growth failure and hyperphagia in children, associated with reversibility of growth-hormone insufficiency."
01/01/2013 - "This neural defect, together with increased fat mass, blunted circadian rhythm, and growth hormone response pathway defects that are also linked to loss of MAGEL2, could contribute to the hyperphagia and obesity that are hallmarks of this disorder."
03/01/2011 - "Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia."

12/01/1988 - "The drug d-fenfluramine was administered chronically to rats whose weight had been increased by exposure to either a fat or CHO-supplemented hyperphagia-inducing diet. "
01/01/1988 - "Were it not for this high rate of defaulting, there might be clearer support for the efficacy of d-fenfluramine in reducing the frequency of overeating and self-induced vomiting in these bulimic patients. "
12/01/1988 - "d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements."
01/01/1988 - "This rat model successfully predicted feeding patterns under a variety of normal and abnormal conditions, including the day-night meal rhythm, the overeating and obesity following ventromedial hypothalamic lesions, and the suppression of appetite by fenfluramine via slowed gastric emptying. "
05/01/1993 - "Although d-fenfluramine is effective in suppressing the overeating, excessive snacking, and excessive carbohydrate consumption which are frequently found in overweight or obese patients, this study suggests that the drug is not an effective treatment for bulimia nervosa."

08/01/2011 - "Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 ± 5 g (ghrelin+CD) vs. 152 ± 5 g (control i.c.v. saline+CD), P<0.001], but the combination of ghrelin plus HFD did not result in significantly greater hyperphagia [150 ± 7 g (ghrelin+HFD) vs. 136 ± 4 g (saline+HFD)]. "
12/01/2015 - "The purpose of this study is to evaluate acylated ghrelin (AG) and unacylated ghrelin (UAG) levels in PWS and investigate their associations with hyperphagia. "
08/06/2015 - "Collectively, these data demonstrate that ghrelin signaling at the VTA level mediates both reward-based eating and fasting-induced hyperphagia and provides a primary target for the control of the intake of rewarding food."
08/06/2015 - "Ghrelin signaling in the ventral tegmental area mediates both reward-based feeding and fasting-induced hyperphagia on high-fat diet."
01/01/2015 - "Circulating ghrelin levels are elevated in young children with PWS long before the onset of hyperphagia, especially during the early phase of poor appetite and feeding. "

01/01/1993 - "Striatal regulation of morphine-induced hyperphagia: an anatomical mapping study."
06/01/1993 - "Previous work has shown that morphine infusion into the ventral striatum results in marked hyperphagia in satiated rats. "
01/01/1993 - "Morphine infusion into anteroventromedial regions including the nucleus accumbens resulted in a marked hyperphagia that was generally delayed in onset; much smaller increases or no change in feeding occurred after administration into more dorsal, lateral and posterior areas. "
11/01/1983 - "In the third experiment, repeated morphine (10 mg/kg) injections over 14 days eliminated 2-DG analgesia on the fifteenth day, but failed to affect 2-DG hyperphagia. "
01/01/1988 - "A single injection of morphine evoked a triphasic influence on feeding: a brief (1 h) severe anorexia was followed by hyperphagia (3 h) and a mild (20%) yet persistent (4-24 h) anorexia. "

04/01/2014 - "Nocturnal ingestions were more likely to co-occur with other NES symptoms than evening hyperphagia, which occurred frequently, but often in isolation; women were more likely to report a co-occurrence of symptoms than men, who were not likely to report distress related to NES symptoms. "
05/01/2011 - "The eating habits questionnaire revealed that physically active co-twins more frequently reported that it is easy to eat according to need, whereas overeating and/or restrictive eating was more common among the inactive co-twins (P = 0·035). "
09/15/2000 - "The dose response of NPY (2.5 microg) co-injected with three levels of BN (0, 0.1 and 0.5 microg) was examined in Experiment 3. ICV injection of BN attenuated the hyperphagia by NPY in a dose-related fashion. "
10/01/1988 - "With respect to hyperphagia, GSH suppressed the effect of SS, probably because of depressing effect of co-administration of SS an GSH."
05/01/2015 - "Although prior studies have demonstrated that depression is associated with an overeating-binge eating dimension (OE-BE) phenotypically, little research has investigated whether familial factors contribute to the co-occurrence of these phenotypes, especially in community samples with multiple racial/ethnic groups. "

08/01/2008 - "Patients who observe the fast should be advised to monitor their blood glucose regularly,avoid skipping meals or overeating,and maintain contact with their physician throughout the fast. "
01/01/2015 - "Compared to db/db mice, INSR; db/db mice were rescued from hyperphagia and obesity, leading to improved blood glucose levels. "
02/01/2013 - "And there are many other spontaneous mutations in different sites of Lepr, which produce a series of animal models of obesity, including db(3J)/ db(3J) mice, db(5j)/db(5J) mice, db(pas)/db(pas) mice, Zucker fa/fa rats, and Koletsky fa(k)/fa(k) rats, etc. These rodents appear similar hyperphagia and severe obesity, but different levels of blood glucose, kidney damage and reproductive ability, providing profuse material to investigate the complex function of Lepr. "
11/01/2008 - "An OLZ-associated development of hyperphagia, weight gain and elevated blood glucose in the rat was also found. "
07/01/2012 - "Food deprivation decreased blood glucose, serum insulin and produced hyperphagia. "

09/01/2009 - "The chronic hyperphagia of lactation is most likely sustained by the induction of NPY in the DMH. "
07/29/2006 - "We have proposed that the absence of DMH CCK-1 receptors significantly contributes to the OLETF's inability to compensate for their meal size control deficit leading to their overall hyperphagia. "
01/15/2016 - "While DMH NPY overexpression causes hyperphagia and obesity in rats, knockdown of NPY in the DMH via adeno-associated virus (AAV)-mediated RNAi (AAVshNPY) ameliorates these alterations. "
05/04/2011 - "Here we report that knockdown of NPY expression in the DMH by adeno-associated virus-mediated RNAi reduced fat depots in rats fed regular chow and ameliorated high-fat diet-induced hyperphagia and obesity. "
01/07/2009 - "Knockdown of NPY expression in the DMH via AAV-mediated RNA interference ameliorated the hyperphagia, obesity, and diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. "

12/01/1995 - "Acute intralateral hypothalamic (LH) administration of MOR or KCZ (1 microgram/rat) enhanced FI during dark and light phases, respectively, whereas intraventromedial hypothalamic (VMH) injections resulted in moderate hyperphagia during dark phases by both mu and kappa agonists. "
12/23/1977 - "Termination of injections was followed by hyperphagia and an accelerated rate of growth. "
06/01/2012 - "Lep-SAP injections into the ventromedial hypothalamic nucleus did not cause hyperphagia, obesity, or arrhythmic feeding in either LD or DD. "
11/01/1984 - "This hyperphagia results in a gradual increase in body weight which develops over the course of a 5-day sequence of repeated NE injections. "
07/01/1979 - "In the present study male and female rats were injected with 2DG (750 mg/kg IP), insulin (regular, 20 U/kg SC) or distilled water, and food intake was compared to baseline levels during the next 1, 6 and 24 hr. Results showed that food intake: (1) was not affected by injections of water: (2) was higher than normal during all 3 time periods following insulin injections: and (3) was higher than normal at 1 and 6 hr following 2DG, but significantly lower than normal by the end of 24 hr. The reasons underlying the development of hypophagia subsequent to the initial hyperphagia produced by 2DG are presently unknown."

01/01/2013 - "Low-protein diets induced sustained hyperphagia and a generalized expansion of fat stores. "
07/01/1980 - "The relative hyperphagia, decreased efficiency of energy utilization and increased oxygen consumption and serum T3 concentrations in the lean rats fed the low-protein diet were consistent with the development of an adaptive thermogenesis, allowing the excess non-protein energy to be dissipated through excess heat production. "
01/04/2012 - "Body composition was measured by dual-energy x-ray absorptiometry biweekly, resting energy expenditure was measured weekly by ventilated hood, and total energy expenditure by doubly labeled water prior to the overeating and weight stabilization periods and at weeks 7 to 8. Overeating produced significantly less weight gain in the low protein diet group (3.16 kg; 95% CI, 1.88-4.44 kg) compared with the normal protein diet group (6.05 kg; 95% CI, 4.84-7.26 kg) or the high protein diet group (6.51 kg; 95% CI, 5.23-7.79 kg) (P = .002). "
06/01/1996 - "Results indicate that a low protein diet effectively blocks development of hyperphagia and obesity in rats with surgical knife cuts between the ventromedial and lateral regions of the hypothalamus."
06/01/1996 - "Because low protein diets can also stimulate diet-induced thermogenesis, we conducted four experiments which examined how diets containing different levels of protein affect development of hyperphagia and obesity in female rats given bilateral, parasagittal wire knife cuts between the ventromedial and lateral areas of the hypothalamus. "

01/01/2009 - "Despite its high prevalence and widespread distribution (consistent with a common underlying etiology), clinical psychologists and primary care physicians routinely approach the problem with individualized but often ineffective treatments like psychotherapy and pharmacotherapy, or propose alterations to specific components of the 'toxic environment', cultural influences, and psychosocial factors purported to cause overeating. "
11/01/1998 - "We used DF in 3 patients with chronic psychosis and severe overeating without changes in psychiatric pharmacotherapy. "
11/01/2012 - "Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. "
01/01/2009 - "Reduced cognitive restraint, increase in hunger, and increased overeating were associated with a higher probability of weight gain > or = 1 kg. The association between weight gain and lack of cognitive restraint in the presence of increased appetite suggests potential benefit of psychoeducational counseling in conjunction with adjunctive pharmacotherapeutic agents in limiting weight gain during antipsychotic drug therapy. "
01/01/2011 - "For patients with a craniopharyngioma (CP), treatment of hypothalamic obesity (HO) and hyperphagia following resection and/or radiotherapy is extremely difficult and few reports have been published on potential drug therapies. "

04/01/2004 - "This is probably associated with infrequent physical activity, both during and after treatment, and hyperphagia."
09/01/2002 - "This produced hyperphagia and obesity: 7 weeks after treatment, those receiving goldthioglucose weighed 70% more than the controls. "
12/14/1998 - "The patients were rated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a scale for the 'atypical' symptoms hypersomnia, hyperphagia and carbohydrate craving (the ATYP scale) before and after treatment. "
01/01/1987 - "The polydipsia and hyperphagia of the streptozotocin diabetic mice were also reduced by Xiaoke, and the effects lapsed after treatment was withdrawn. "
04/01/1999 - "In comparison with the CSR group, the ISR group had a longer duration of illness, more often used antidepressants, and improved significantly less after treatment with bright light for 6 days, whereas the symptomatology in winter (Montgomery-Asberg Depression Rating Scale plus hypersomnia, hyperphagia, and carbohydrate craving) was similar in the two groups. "

11/01/1983 - "While 2-DG hyperphagia was eliminated by this procedure, 2-DG analgesia was significantly potentiated. "
11/01/1983 - "In the fourth experiment, lesions placed in either the lateral hypothalamus or zona incerta decreased 2-DG hyperphagia, but failed to affect 2-DG analgesia. "
11/01/1983 - "While 2-DG hyperphagia persisted in the absence of glucoprivation, 2-DG analgesia failed to occur after this delay. "
09/01/1997 - "Antisense probes directed against only exon 1 or 4 blocked hyperphagia at agonist doses of 0.5 and 1.0 microg; this pattern was identical to that observed for mu-mediated analgesia. "
07/01/1986 - "Second, while scopolamine (1 mg/kg) and methylscopolamine (1,10 mg/kg) pretreatment prolonged 2DG analgesia, both antagonists dose-dependently reduced 2DG hyperphagia. "