Hyperoxaluria (Oxaluria)

03/20/2017 - "Identifying dietary hyperoxaluria as the cause of CKD is important because the decrease in dietary oxalate intake without any other measures can lead to sustained improvement in renal function."
07/01/2004 - "Hyperoxaluria was finally diagnosed by elevated urine oxalate (1.235 mmol/24 h) and renal biopsy, by which time there was already significant reduction of renal function. "
01/01/1994 - "Rapid clearance of oxalate after transplant leads to transient hyperoxaluria until normal levels of serum oxalate are reached."
07/01/2019 - "Oxalobacter formigenes, an obligate oxalotrophic bacterium in the mammalian intestine, has generated great interest as a potential probiotic or therapeutic treatment for oxalate-related conditions due to its ability to degrade both exogenous (dietary) and endogenous (metabolic) oxalate, lowering the risk of hyperoxaluria/hyperoxalemia. "
11/01/2005 - "Oxalate degrading bacteria: new treatment option for patients with primary and secondary hyperoxaluria?"

11/01/2022 - "Our study is in line with previous observations made in the mouse showing that SLC26A6 inactivation can cause inherited enteric hyperoxaluria with calcium oxalate NL. "
07/01/2005 - "Histopathological examination showed that there was no deposition of calcium oxalate crystals in rats in group 2. This is the first study to demonstrate in-vivo evidence that hyperoxaluria-induced peroxidative injury induces individual calcium oxalate crystal attachment in the renal tubules. "
08/01/1995 - "Monolayer cultures of nontransformed monkey kidney epithelial cells (BSC-1 line) and calcium oxalate monohydrate (COM) crystals were used as a model system to study cell responses to crystal interactions that might occur in the nephrons of patients during periods of hyperoxaluria. "
01/01/1995 - "The results of these studies led us to hypothesize that hyperoxaluria promotes stone formation in several ways: by providing a substrate for the formation of the most common form of renal stones, calcium oxalate stones, and by inducing damage to renal epithelial cells. "
04/01/1974 - "Calcium oxalate retinopathy associated with generalized oxalosis: x-ray diffraction and electron microscopic studies of crystal deposits."

03/01/2017 - "We analyzed phospho-calcium metabolism as well as the calciuria, oxaluria, citraturia and uricosuria levels with fasting and 24-hour urine study. "
06/01/2002 - "The aim of the present study was to evaluate oxaluria in normocalciuric and hypercalciuric lithiasic patients under different calcium intake. "
08/29/2023 - "Numerous arterial walls in the left orbit, including short posterior ciliary arteries and the central retinal artery, contained hundreds of crystals with anisotropic, colorful birefringence consistent with calcium oxalosis. "
11/01/2019 - "This randomized, double-blind, placebo-controlled, parallel-group clinical trial included 32 adults with recurrent calcium stone formation and hyperoxaluria. "
02/01/2019 - "Eighteen months later, a second PET/CT showed decreased F-FDG uptake, reflecting treatment efficacy on inflammatory reaction secondary to calcium oxalosis skeletal deposits."

06/01/2012 - "The present study aims at systematic evaluation of the calyces of Hibiscus sabdariffa to establish its scientific validity for anti-urolithiatic property using ethylene glycol-induced hyperoxaluria model in male albino rats. "
04/01/1971 - "[Ultrastructural study of the kidney in experimental oxalosis induced with ethylene glycol]."
01/01/2023 - "An ethylene glycol- (EG-) induced hyperoxaluria rat model and an in vitro model of COM-induced HK-2 cells coculturing with RAW264.7 cells were established to explore the protective mechanisms of ADSC-derived miR-23-enriched exosomes. "
08/01/2019 - "Hyperoxaluria was induced with ethylene glycol for comparison to controls (water). "
01/01/2018 - "Twenty 5- to 6-week-old male Wistar rats were divided into control and hyperoxaluria groups (n = 10 per group) and were supplied with normal water or 1% ethylene glycol, respectively, for 16 weeks. "

03/01/2005 - "Approximately half of PHI patients experience improvement in the degree of hyperoxaluria following pyridoxine (VB6) treatment. "
06/27/1981 - "Hyperoxaluria and recurrent stone formation apparently cured by short courses of pyridoxine."
05/01/2011 - "Pyridoxine and dietary counseling for the management of idiopathic hyperoxaluria in stone-forming patients."
03/01/1998 - "From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not to normal level-in the remaining 30%. "
11/01/1996 - "The hyperoxaluria was unresponsive to pyridoxine. "

06/01/2008 - "Thus, it shows that use of an extraneous antioxidant may prove beneficial for combating the conditions of oxidative stress produced by hyperoxaluria."
01/01/2023 - "Mechanistically, HCA prevented crystal deposition and oxidative stress induced by hyperoxaluria through targeting the Nrf2/Keap1 antioxidant defense pathway, while knockdown of Nrf2 significantly abrogated these effects. "
03/01/2011 - "To examine the effect of anti-oxidants on hyperoxaluria-induced changes in kidney, the enzymatic and non-enzymatic anti-oxidant levels were assessed. "
09/01/2008 - "Increase in oxidative milieu in hyperoxaluria was evident by increased lipid peroxidation (LPO) and decreased enzymic and nonenzymic antioxidants. "
11/01/2005 - "Hyperoxaluria-induced oxidative stress and antioxidants for renal protection."

02/01/2002 - "This study was aimed to determine whether hyperoxaluria modifies the kinetic properties of urinary inhibitory proteins. "
11/17/2017 - "In conclusion, HLP-induced hyperoxaluria reduced the kidney Klotho protein level, which could be restored by Vit E and/or Vit C."
09/01/2007 - "The in vitro transcription assay demonstrated the repression effect of the protein on gene expression during hyperoxaluria. "
09/01/2007 - "Persistent hyperoxaluria leads to tubular epithelial injury, resulting in the release of these anti-inflammatory proteins. "
02/01/2002 - "In hyperoxaluria, the urinary excretion of this protein significantly increased. "

10/01/2011 - "Improved methodology to induce hyperoxaluria without treatment using hydroxyproline."
03/01/2010 - "In this study, we sought to create a model of hyperoxaluria in the adult sow by feeding hydroxyproline (HP). "
03/01/2010 - "Hydroxyproline-induced hyperoxaluria using acidified and traditional diets in the porcine model."
05/01/2012 - "The purpose of our study was to determine if a hydroxyproline (HP) or gelatin diet could induce long-term hyperoxaluria in the porcine model. "
10/01/2011 - "The use of hydroxyproline (HP) to generate hyperoxaluria in the rat is a problem because it is impossible to separate the effect of oxalate on renal injury from the effects of HP and the large array of metabolic intermediates formed when HP is converted to oxalate. "

07/01/2013 - "Hyperoxaluria induced renal damage was evident from the decreased activities of tissue marker enzymes and an apparent escalation in their activity in the urine in control animals; this was prevented by B. "
06/01/2011 - "PH1 is an inborn error of the metabolism in which a functional deficiency of the liver-specific peroxisomal enzyme, AGT, causes hyperoxaluria and hyperglycolic aciduria. "
01/28/2008 - "Hyperoxaluria induced a decrease in the activities of TCA cycle enzymes and respiratory complex enzymes. "
01/01/2001 - "A comparison was made of quantitative enzyme assay of registering 24-h oxaluria (Lartillot M. "
08/15/1990 - "Measurements under these optimal conditions enabled the biochemical diagnosis of hyperoxaluria type I to be made via enzyme activity measurements in percutaneous needle biopsy specimens of liver tissue."

08/01/2006 - "Another group of EG-treated rats received 200 mg kg(-1) of vitamin E intraperitoneally (EG+E group) to evaluate its effect on hyperoxaluria. "
06/01/2003 - "Supplementation of vitamin E and selenium prevents hyperoxaluria in experimental urolithic rats."
02/01/1997 - "On pretreatment with vitamin E the cyclosporin A-induced biochemical changes observed in the presence of hyperoxaluria were abolished."
02/01/2012 - "Hyperoxaluria-induced tubular ischemia: the effects of verapamil and vitamin E on apoptotic changes with an emphasis on renal papilla in rat model."
07/01/2005 - "One group (n = 100) was administered the antioxidant vitamin E at 400 mg/day given as an oral supplement along with standard therapeutic drugs for hypertension and hyperoxaluria and the patients were followed for a period of 9 months. "

01/01/2015 - "formigenes preparation is more effective in decreasing the incidence of hyperoxaluria, opening the door to probiotic therapy as a potential new weapon against hyperoxaluria."
06/21/2023 - "Currently, there are no US Food and Drug Administration-approved therapies for enteric hyperoxaluria, and it is unclear what end points should be used to evaluate the efficacy of new drugs and biologics for this condition. "
06/01/2022 - "Hyperoxaluria is a severe challenge in nephrology and has led to the novel gut eubiosis as current therapy. "
02/01/2022 - "Therapies for hyperoxaluria and ON are reviewed with an emphasis on newer treatments available and in development. "
01/01/2021 - "These findings could facilitate the development of novel therapeutics for hyperoxalemia, hyperoxaluria, and related disorders if similar regulatory mechanisms are confirmed in humans."

12/01/2021 - "Hyperoxaluria: An early diagnosis will allow a timely combined renal and liver transplantations to avoid irreversible damages to all other organs."
09/01/2018 - "In our patient, we anticipate that liver transplantation will cure both the hyperoxaluria and the hypercoagulable state."
10/01/2013 - "Native portal vein embolization for persistent hyperoxaluria following kidney and auxiliary partial liver transplantation."
11/01/2005 - "6. Living donor liver transplantation for metabolic disorders like Alpha-1-Antitrypsin deficiency, Hyperoxaluria, and others cannot be recommended at present since the genetically related donor and the patient may carry an unknown risk."
09/15/2002 - "Among the patients with oxalosis, 56 patients had a liver transplant followed by a kidney transplant (LKTx) and 134 patients had a kidney transplant alone (KTA). "

04/01/2021 - "Roux-en-Y gastric bypass was the only significant predictor of post-operative hyperoxaluria (OR 7.1 [95% CI 2.3-21.3], p = 0.001). "
01/01/2020 - "Lessons from rodent gastric bypass model of enteric hyperoxaluria."
12/01/2017 - "Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats."
01/01/2017 - "Is the intestinal microbiome a modifiable cofactor in the development of hyperoxaluria after Roux-en-Y gastric bypass?"
01/01/2017 - "Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. "

02/01/2016 - "Enteric hyperoxaluria is a common occurrence in the setting of fat malabsorption, usually due to intestinal resection or intestinal bypass surgery. "
07/01/2001 - "Enteric hyperoxaluria is a commonly seen adverse event after the jejunoileal bypass procedure. "
12/13/1986 - "Group 2 consisted of 4 patients with enteric hyperoxaluria after intestinal bypass surgery. "
03/01/1983 - "Eleven patients with hyperoxaluria (greater than 0.45 mmol/24 h) after jejunoileal bypass were therefore studied under surgical ward conditions for 5 days. "
02/01/1983 - "Complex pathogenesis of hyperoxaluria after jejunoileal bypass surgery. "

01/01/2019 - "Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). "
03/01/2018 - "If confirmed, bone oxalosis is the proof of disease severity and that combined liver-kidney transplantation should be performed."
12/01/2017 - "This is the first systematic description of kidney transplantation in a cohort of patients with enteric hyperoxaluria. "
12/01/2017 - "A Successful Approach to Kidney Transplantation in Patients With Enteric (Secondary) Hyperoxaluria."
03/01/2017 - "Hyperoxaluria After Renal Transplantation."