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Congenital Cortical Hyperostosis (Infantile Cortical Hyperostosis)

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A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)

Also Known As:

Infantile Cortical Hyperostosis; Hyperostosis, Cortical Congenital; Hyperostosis, Cortical, Congenital; Congenital Hyperostosis, Cortical; Cortical Congenital Hyperostosis; Caffey De Toni Silvermann Syndrome; Congenital Cortical Hyperostoses; Congenital Hyperostoses, Cortical; Cortical Congenital Hyperostoses; Cortical Hyperostoses, Congenital; Cortical Hyperostoses, Infantile; Cortical Hyperostosis, Infantile; Hyperostoses, Congenital Cortical; Hyperostoses, Cortical Congenital; Hyperostoses, Infantile Cortical; Hyperostosis, Congenital Cortical; Hyperostosis, Infantile Cortical; Infantile Cortical Hyperostoses; Syndrome, Caffey-De Toni-Silvermann; Caffey-De Toni-Silvermann Syndrome; Cortical Hyperostosis, Congenital

Networked: 40 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperostosis
2.	Fever (Fevers)
3.	Thrombocytosis (Thrombocythemia)
4.	Inflammation
5.	Rare Diseases (Rare Disease)

Experts

1.	Jüppner, Harald: 2 articles (06/2014 - 05/2005)
2.	Mäkitie, Outi: 2 articles (07/2011 - 05/2005)
3.	Le Merrer, Martine: 2 articles (09/2009 - 07/2008)
4.	Kamoun-Goldrat, Agnès: 2 articles (10/2008 - 07/2008)
5.	Kubota, Takuo: 1 article (06/2014)
6.	Miyoshi, Yoko: 1 article (06/2014)
7.	Hasegawa, Tomonobu: 1 article (06/2014)
8.	Miura, Kohji: 1 article (06/2014)
9.	Ohata, Yasuhisa: 1 article (06/2014)
10.	Fujiwara, Makoto: 1 article (06/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital Cortical Hyperostosis:

1.	Caffey diseaseIBA 07/01/2013 - "Infantile cortical hyperostosis (Caffey disease): a case report and review of the literature--where are we after 70 years?" 07/01/2011 - "Caffey disease or infantile cortical hyperostosis is a rare skeletal disorder with both sporadic and familial occurrence. " 10/01/2010 - "Infantile cortical hyperostosis (Caffey disease) is a rare self-limiting inflammatory bony disease of early infancy. " 10/01/2010 - "Infantile cortical hyperostosis (Caffey disease): a possible misdiagnosis as physical abuse." 04/01/2010 - "Caffey disease or Infantile Cortical Hyperostosis (ICH) is a rare and mostly self limiting condition affecting young infants. "
2.	Immunoglobulins (Immunoglobulin)IBA 04/30/1984 - "[Description of a case of infantile cortical hyperostosis with thrombocytemia and an increase of immunoglobulins]." 12/01/1979 - "Infantile cortical hyperostosis with raised immunoglobulins." 05/01/1978 - "Infantile cortical hyperostosis with raised immunoglobulins." 12/01/1972 - "Raised immunoglobulin levels and thrombocytosis in infantile cortical hyperostosis."
3.	Adrenocorticotropic Hormone (ACTH)FDA Link 03/01/1952 - "Infantile cortical hyperostosis: report of a case responding to treatment with corticotropin." 10/01/1955 - "[Infantile cortical hyperostosis; presentation of a case treated with hydrocortisone and corticotropin; review of the literature]."
4.	tebufenozide (Mimic)IBA 01/01/2009 - "Professional awareness is needed to distinguish between child physical abuse from other disorders that can mimic signs of abuse (Skull base sclerosis in infant manifesting features of infantile cortical hyperostosis): a case report and review of the literature." 10/01/1979 - "Infantile cortical hyperostosis may mimic a variety of serious conditions in early infancy, such as trauma, vitamin deficiencies, infection, or tumors, In a patient in good general condition there are typical roentgenological features often with involvement of the mandible that are diagnostic of the condition. "
5.	Technetium Tc 99m MedronateIBA 03/01/1983 - "Two patients with infantile cortical hyperostosis (Caffey's disease) are presented in whom radionuclide imaging with 99mTc-MDP and 67Gallium-citrate was performed to eliminate multifocal osteomyelitis as a diagnosis. "
6.	PhosphorusIBA 01/01/1991 - "The effects on mineral metabolism of therapeutic doses of corticosteroids were investigated in infantile cortical hyperostosis; in four untreated cases the calcium, phosphorus, and magnesium balances were strongly positive. "
7.	MagnesiumIBA 01/01/1991 - "The effects on mineral metabolism of therapeutic doses of corticosteroids were investigated in infantile cortical hyperostosis; in four untreated cases the calcium, phosphorus, and magnesium balances were strongly positive. "
8.	Immunoglobulin M (IgM)IBA 05/01/1976 - "An infant is described who presented with ptosis and periorbital oedema and was found to have infantile cortical hyperostosis with thrombocytosis, raised IgM, and vitamin E deficiency."
9.	Hydrocortisone (Cortisol)FDA LinkGeneric 10/01/1955 - "[Infantile cortical hyperostosis; presentation of a case treated with hydrocortisone and corticotropin; review of the literature]."
10.	HormonesIBA 08/01/1955 - "Infantile cortical hyperostosis: treatment with hormones."

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 01/01/1998 - "These cases suggest that the improved outcome of congenital of infantile cortical hyperostosis may reflect improvement of neonatal mechanical ventilation and availability of neonatal total parenteral nutrition."
2.	Total Parenteral Nutrition 01/01/1998 - "These cases suggest that the improved outcome of congenital of infantile cortical hyperostosis may reflect improvement of neonatal mechanical ventilation and availability of neonatal total parenteral nutrition."
3.	Sutures (Suture) 10/01/1977 - "Authors present a case of infantile cortical hyperostosis with several clinical and radiologic unusual aspects they principally stand out the observation of hypotonia and widely split sutures, possibly never published before."