Hyperglycemic Hyperosmolar Nonketotic Coma (Nonketotic Hyperglycemic Coma)

A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
2.	Septic Shock (Toxic Shock Syndrome)
3.	Disseminated Intravascular Coagulation
4.	Acquired Immunodeficiency Syndrome (AIDS)

Experts

1.	Lartey, Richard: 1 article (02/2009)
2.	Shih, Richard: 1 article (02/2009)
3.	Campanella, Lisa Marie: 1 article (02/2009)
4.	Decobert, Marion: 1 article (10/2006)
5.	Devictor, Denis: 1 article (10/2006)
6.	Tissières, Pierre: 1 article (10/2006)
7.	Buisine, Anne: 1 article (10/2006)
8.	Durand, Philippe: 1 article (10/2006)
9.	Chevret, Laurent: 1 article (10/2006)
10.	Haas, Vincent: 1 article (10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperglycemic Hyperosmolar Nonketotic Coma:

1.	Lactic AcidFDA LinkGeneric 09/01/1998 - "Other statistically significant prognostic factors included septic shock, initial level of consciousness, hyperosmolar hyperglycemic nonketotic coma, disseminated intravascular coagulation, high cerebrospinal fluid lactate levels and leucocytosis. "
2.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 10/14/1995 - "[Nonketotic hyperglycemic coma induced by somatostatin in an AIDS patient]."
3.	Methadone (Dolophine)FDA LinkGeneric 10/01/2006 - "Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion."
4.	Loxapine (Loxitane)FDA Link 09/01/1983 - "A case of nonketotic hyperglycemic coma associated with the recent introduction of loxapine is presented. "
5.	Insulin (Novolin)FDA Link 05/01/1982 - "Optimal insulin delivery in diabetic ketoacidosis (DKA) and hyperglycemic, hyperosmolar nonketotic coma (HHNC)."
6.	Diazoxide (Hyperstat)FDA Link 07/01/1977 - "Hyperglycemic hyperosmolar nonketotic coma following diazoxide, anesthesia and operation."
7.	Chlorthalidone (Chlortalidone)FDA LinkGeneric 06/19/1972 - "Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma."
8.	Blood Glucose (Blood Sugar)IBA 07/01/1977 - "Blood glucose should be measured during and after general anesthesia in patients who are potential candidates for hyperglycemic hyperosmolar nonketotic coma."
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 10/01/1983 - "We report three cases of ophthalmic problems that were treated with a short course of oral corticosteroids and which resulted in the development of hyperosmolar hyperglycemic nonketotic coma. "
10.	aripiprazole (Abilify)FDA Link 02/01/2009 - "Severe hyperglycemic hyperosmolar nonketotic coma in a nondiabetic patient receiving aripiprazole."

Therapies and Procedures

1.	Peritoneal Dialysis 07/01/1968 - "Hyperosmolar hyperglycemic nonketotic coma during peritoneal dialysis."
2.	Total Parenteral Nutrition 05/01/1973 - "Hyperosmolar hyperglycemic nonketotic coma complicating intravenous hyperalimentation."
3.	Fluid Therapy (Oral Rehydration Therapy) 04/01/1990 - "Concepts of fluid therapy in diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma."
4.	Cholecystectomy 09/01/1974 - "Hyperosmolar hyperglycemic nonketotic coma in a patient undergoing emergency cholecystectomy."
5.	General Anesthesia 07/01/1977 - "Blood glucose should be measured during and after general anesthesia in patients who are potential candidates for hyperglycemic hyperosmolar nonketotic coma."