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Hyperesthesia

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Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.

Also Known As:

Hyperesthetic Sensations; Oxyesthesia; Hyperesthesias; Hyperesthesias, Tactile; Hyperesthesias, Thermal; Hyperesthetic Sensation; Oxyesthesias; Sensation, Hyperesthetic; Sensations, Hyperesthetic; Tactile Hyperesthesia; Tactile Hyperesthesias; Thermal Hyperesthesia; Thermal Hyperesthesias; Hyperesthesia, Tactile; Hyperesthesia, Thermal

Networked: 107 relevant articles (9 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Inflammation
3.	Vaginismus
4.	Referred Pain
5.	Muscle Weakness

Experts

1.	Lee, Susan Shin-Jung: 2 articles (10/2011 - 08/2004)
2.	Tsai, Hung-Chin: 2 articles (10/2011 - 08/2004)
3.	Ramnauth, Jailall: 2 articles (09/2011 - 08/2011)
4.	Mladenova, Gabriela: 2 articles (09/2011 - 08/2011)
5.	Annedi, Subhash C: 2 articles (09/2011 - 08/2011)
6.	Rakhit, Suman: 2 articles (09/2011 - 08/2011)
7.	Porreca, Frank: 2 articles (09/2011 - 08/2011)
8.	Renton, Paul: 2 articles (09/2011 - 08/2011)
9.	Andrews, John: 2 articles (09/2011 - 08/2011)
10.	Speed, Joanne: 2 articles (09/2011 - 08/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperesthesia:

1.	Prednisone (Sone)FDA LinkGeneric 01/01/1984 - "Myalgias and hyperesthesias were markedly relieved with prednisone 5 mg twice daily. " 01/01/1984 - "Myalgias and hyperesthesias were markedly relieved with prednisone 5 mg twice daily. "
2.	StrychnineIBA 11/01/1989 - "Over the range of 0.3-1.0 nmol these agents produced a dose-dependent inhibition of the strychnine-evoked hyperesthesia. " 09/01/1989 - "In addition, 5'-(N-ethylcarboxamido)-adenosine and N6-(L-2-phenylisopropyl)-adenosine both suppressed the chemically evoked writhing response as well as the touch-evoked hyperesthesia normally observed in rats receiving low doses of intrathecal strychnine. " 11/01/1989 - "This effect is in contrast to opioids, which have been reported to be only minimally effective against strychnine-evoked hyperesthesia. " 11/01/1989 - "The powerful effect of adenosine analogues on strychnine hyperesthesia occur at doses that have only a mild analgesic effect on the thermally evoked hot-plate response. " 04/01/1989 - "The lack of effect of agents having a powerful effect on somatic pain stimuli and the converse effects of glutamate receptor antagonists on the strychnine hyperesthesia at doses which do not affect the somatic pain response indicate discriminable processing systems, the characteristics of which resemble the clinical phenomenon observed in patients suffering from sensory dysesthesia following central and peripheral horn injury."
3.	Mesna (Coenzyme M)FDA LinkGeneric 10/01/2007 - "TMC asymmetry 1) was generated in strict relation with cystitis, and was absent in disease-free and mesna-treated animals, 2) was restricted to the anterior portion of the paraventricular pars anterior and reuniens nuclei subregion, i.e., the rostralmost part of the paraventricular thalamic nucleus, the only thalamic area associated with viscero-vagal and somatic inputs, via the nucleus of the solitary tract, and via the medial contingent of the spinothalamic tract, respectively, and 3) originated from somatic tissues, i.e., the abdominal wall where bladder inflammation generates secondary somatic hyperesthesia leading to referred pain in humans. "
4.	Lidocaine (Xylocaine)FDA LinkGeneric 11/01/2006 - "We report a case of primary vaginismus with associated pain that benefited from topical application of lignocaine gel along with systematic desensitization resulting in successful consummation, and suggest that it may be a useful adjunct during finger dilatation in the treatment of vaginismus, specifically in patients who have associated pain or areas of hyperesthesia in the introitus."
5.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 06/01/2009 - "Hyperesthesia improved and child walked with support following administration of vitamin C."
6.	Opioid Analgesics (Opioids)IBA 11/01/1989 - "This effect is in contrast to opioids, which have been reported to be only minimally effective against strychnine-evoked hyperesthesia. "
7.	Morphine (MS Contin)FDA LinkGeneric 10/01/1996 - "Intrathecal morphine had no effect on the development of thermal hyperesthesia in this study. " 05/01/1986 - "High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications." 09/01/1991 - "Complications occurred in 11 of the 16 cases of epidural analgesia and included dislodged or broken catheters, pain on injection, hyperesthesia from epidural morphine and bleeding or infection related to the epidural catheter. " 10/01/1996 - "The current study investigated the effect of spinally administered morphine and clonidine, an alpha 2 agonist, on the development of thermal hyperesthesia induced by nerve constriction injury in the rat. " 10/01/1996 - "Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat."
8.	Dizocilpine Maleate (Dizocilpine)IBA 11/01/1993 - "When (+)-MK-801 was administered 15 min after the nerve injury, (+)-MK-801 had no effect on the development of hyperesthesia. " 11/01/1993 - "Intrathecal (+)-MK-801 also delayed the development of hyperesthesia when (+)-MK-801 was administered intrathecally 15 min before the nerve injury. " 03/01/1995 - "Intrathecal clonidine and MK-801 alone produced dose-dependent reductions of tactile hyperesthesia: ED50 9 micrograms and 10 micrograms, respectively. " 06/01/1994 - "The current study investigated the time dependency of the effects of intrathecal morphine and MK-801, an N-methyl-D-aspartate antagonist, on the thermal hyperesthesia evoked by unilateral constriction injury to the sciatic nerve in the rat. " 03/01/1995 - "Using a fixed-dose analysis and an isobolographic paradigm, the spinal interaction between the alpha 2-adrenoceptor agonist clonidine and the N-methyl-D-aspartate antagonist MK-801 is characterized in a rat model of nerve injury-induced tactile hyperesthesia. "
9.	N-Methylaspartate (NMDA)IBA 05/01/1995 - "It is known that the N-methyl-D-aspartate receptor plays an important role in the development of the spinal facilitation evoked by a protracted small afferent input and that this effect is mediated at least in part by NO. Recently, it has been found that N-methyl-D-aspartate receptor-mediated spinal facilitation is crucial in the development of thermal hyperesthesia evoked by a nerve constriction injury. " 03/01/1995 - "Spinally delivered alpha 2-adrenoceptor agonists and N-methyl-D-aspartate antagonists each have been shown to have actions attenuating the hyperesthesia in rat models of nerve injury pain. " 01/01/2013 - "The N-Methyl-4-isoxazoleproionic acid (NMDA) antagonist Norketamine also significantly diminished hyperesthesia and decreased receptor expression in the dorsal horn. " 06/01/1994 - "These data indicate that (1) an N-methyl-D-aspartate receptor-mediated spinal facilitation may be the common mechanism maintaining the thermal hyperesthesia evoked by the constriction injury, and (2) the effects of intrathecal morphine on this thermal hyperesthesia are time-dependent." 06/01/1994 - "The current study investigated the time dependency of the effects of intrathecal morphine and MK-801, an N-methyl-D-aspartate antagonist, on the thermal hyperesthesia evoked by unilateral constriction injury to the sciatic nerve in the rat. "
10.	Clonidine (ST 155)FDA LinkGeneric 10/01/1996 - "Pretreatment, but not posttreatment, with intrathecal clonidine significantly delayed the development of thermal hyperesthesia in a dose-dependent manner, and this delay in onset produced by clonidine was 3 days after the nerve injury. " 10/01/1996 - "The current study investigated the effect of spinally administered morphine and clonidine, an alpha 2 agonist, on the development of thermal hyperesthesia induced by nerve constriction injury in the rat. " 10/01/1996 - "Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat." 03/01/1995 - "Intrathecal clonidine and MK-801 alone produced dose-dependent reductions of tactile hyperesthesia: ED50 9 micrograms and 10 micrograms, respectively. " 03/01/1995 - "Using a fixed-dose analysis and an isobolographic paradigm, the spinal interaction between the alpha 2-adrenoceptor agonist clonidine and the N-methyl-D-aspartate antagonist MK-801 is characterized in a rat model of nerve injury-induced tactile hyperesthesia. "

Therapies and Procedures

1.	Surgical Decompression 01/01/2007 - "Surgical decompression of the infraorbital nerve can provide significant symptomatic improvement in patients with chronic infraorbital nerve hyperesthesia secondary to nerve compression." 01/01/2007 - "To present three cases of chronic infraorbital nerve hyperesthesia relieved by surgical decompression of the infraorbital nerve. " 01/01/2007 - "Infraorbital nerve surgical decompression for chronic infraorbital nerve hyperesthesia." 01/01/2007 - "In each case, patients had dramatic relief of infraorbital nerve hyperesthesia and pain after surgical decompression of the infraorbital nerve. "
2.	Dental Prosthesis 05/01/1996 - "It is effective for patients with hyperesthesia caused by dental prosthesis and resorption of the alveolar ridge caused by aging. "
3.	Plasmapheresis 10/01/2001 - "We performed plasmapheresis four times, which improved her level of consciousness, hyperesthesia, external ophthalmoplegia and muscle weakness, and led to the normalization of brain and spinal cord MRI. "
4.	Anesthesia 06/01/1986 - "It may be due to hyperesthesia (comparable to that seen in humans after peripheral nerve injury) or anesthesia (as an attempt to shed an insensate appendage). " 03/01/1976 - "Among the objective changes, anesthesia of superficial sensibilities combined with deep hyperesthesia and anesthesia of superficial sensibilities with abolition of profound sensibilities were rarely observed. " 01/01/2010 - "Possible sensitivity disorders are paresthesia, anesthesia, hypoaesthesia, dysesthesia, and hyperesthesia.The" 12/01/1997 - "Resolution of primary vaginismus and introital hyperesthesia by topical anesthesia." 05/01/2008 - "Sensory disturbances such as paresthesia, anesthesia, hypoesthesia, and hyperesthesia may be present in the oral cavity. "
5.	Ligation 09/10/2003 - "Spinal nerve ligation (SNL) produced expected tactile and thermal hyperesthesias. " 10/01/1996 - "A model of thermal hyperesthesia induced by a constriction injury created by making four loose ligatures around the rat sciatic nerve was used to examine the development of thermal hyperesthesia. " 05/01/1995 - "The Bennett and Xie model (four loose chromic gut ligations around the rat sciatic nerve) was used to examine the development of thermal hyperesthesia. " 03/01/1995 - "Rats with nerve ligation showed a reliable tactile hyperesthesia (mechanical threshold 1-3 g vs. normal > 15 g). " 11/01/1993 - "A model of thermal hyperesthesia caused by a constriction injury created by making four loose ligations around the rat sciatic nerve was examined. "