Hyperbilirubinemia

A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.

Also Known As:

Networked: 2818 relevant articles (99 outcomes, 242 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cholestasis
2.	Jaundice
3.	Liver Failure
4.	Gilbert Disease
5.	Kernicterus

Experts

1.	Stevenson, David K: 18 articles (09/2015 - 10/2002)
2.	Kaplan, Michael: 17 articles (11/2014 - 10/2002)
3.	Hammerman, Cathy: 16 articles (11/2014 - 10/2002)
4.	Wong, Ronald J: 15 articles (09/2015 - 10/2004)
5.	Vreman, Hendrik J: 12 articles (09/2015 - 10/2002)
6.	Bhutani, Vinod K: 12 articles (02/2015 - 08/2004)
7.	Newman, Thomas B: 11 articles (03/2015 - 05/2003)
8.	Verkade, Henkjan J: 9 articles (01/2015 - 03/2005)
9.	Huang, Ching-Shan: 8 articles (08/2014 - 07/2002)
10.	Kaplan, M: 8 articles (07/2013 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperbilirubinemia:

1.	BilirubinIBA 12/01/2010 - "The Bhutani et al bilirubin nomogram reliably identified infants at gestational age of older than 35 weeks with direct Coombs-positive results who were at risk for significant hyperbilirubinemia and directed the timing of follow-up for these infants. " 01/01/1999 - "A single dose of SnMP proved effective in controlling severe hyperbilirubinemia in full-term breastfed newborns with high bilirubin levels between 48 and 96 hours. " 11/01/1992 - "The conclusion of our study is that the Wallaby System is useful in the treatment of neonatal nonhemolytic hyperbilirubinemia even if its effectiveness for higher bilirubin levels has still to be tested." 04/01/1996 - "Serial determinations of free bilirubin appear to be more helpful in the management of hyperbilirubinemia in infants with an increased risk of bilirubin toxicity." 07/01/2007 - "Our results suggest that the regime adopted is effective for detecting and preventing hyperbilirubinemia at risk of causing bilirubin-induced encephalopathy in term and near term newborn infants."
2.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 07/01/1991 - "Ursodeoxycholic acid (600 mg/day) led to a prompt and sustained improvement in his hyperbilirubinemia. " 01/01/2016 - "The present study aimed to investigate the effect of ursodeoxycholic acid in reducing indirect hyperbilirubinemia of infants under phototherapy. " 01/01/2016 - "Ursodeoxycholic acid had additive effect with phototherapy in neonates with indirect hyperbilirubinemia. " 01/01/2016 - "Effect of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates Treated With Phototherapy." 11/01/2002 - "The purpose of this study was to evaluate the efficacy of ursodeoxycholic acid (UDCA) in the treatment of cholestasis and hyperbilirubinemia in a pediatric intensive care unit population. "
3.	EnzymesIBA 12/01/1992 - "The characteristics of her transient hepatic dysfunction were: early appearance (during the first day of life); discrepancy between the normal liver enzymes and high GGT concentrations; slow decrease of GGT, which nevertheless remained at above-normal concentrations even after the complete disappearance of direct hyperbilirubinemia; and spontaneous resolution in spite of only occasional breastfeeding. " 01/01/2013 - "Hereby, we describe a 37-year-old lady who presented to the outpatient clinic with bloating and abdominal discomfort with intermittent elevated liver enzymes and hyperbilirubinemia. " 02/01/2012 - "Liver enzymes were mildly elevated except one case with marked hyperbilirubinemia. " 12/01/2010 - "After the skin, the liver is the second, most frequent target of GVHD, which presenting with hyperbilirubinemia, elevated liver enzymes, and coagulopathy. " 09/01/2010 - "Liver function tests were impaired with raised liver enzymes, conjugated and unconjugated hyperbilirubinemia. "
4.	Glucose (Dextrose)FDA LinkGeneric 05/01/1982 - "Refeeding the base-line diet reduced the hyperbilirubinemia by 66% in 12 hours, which was a significantly greater reduction than the effect of all other treatments except the largest dose of glucose given by intragastric route. " 05/01/2009 - "Late preterm infants: severe hyperbilirubinemia and postnatal glucose homeostasis." 07/14/1995 - "Hyperbilirubinemia induced widespread decreases in LCMRglcs at P10 and had rather limited consequences on cerebral glucose utilization at P21. " 03/01/1993 - "Hyperbilirubinemia occurred in 55% of babies in the glucose group compared with 21% and 22% in the saline and control groups, respectively (P < 0.001). " 05/01/1982 - "Effect of glucose administration on equine fasting hyperbilirubinemia."
5.	TransaminasesIBA 12/01/1990 - "Consequently, no hyperbilirubinemia and abnormal values of the serum transaminases were revealed in these neonates, and good results of nutritional supports were obtained by cyclic TPN. " 01/01/2003 - "In HG virus monoinfection, biochemical studies revealed the enhanced activity of transaminases and hyperbilirubinemia that was absent in the mixed variant of HGV + HCV. " 04/01/2014 - "Laboratory tests showed elevated liver transaminases with direct hyper-bilirubinemia. " 05/01/2012 - "Four percent of patients with and 3% of patients without hyperbilirubinemia had grade 3-4 elevations in liver transaminases. " 06/01/2009 - "Twenty eight patients (45%) had predominantly conjugated or mixed hyperbilirubinemia and serum transaminases were more than three times normal. "
6.	Phenobarbital (Luminal)FDA Link 04/01/2004 - "There was no significant reduction in incidence of hyperbilirubinemia in phenobarbitone group compared to in placebo group (6/37 (16.2%) versus 13/38 (34.3%); RR 0.47, 95% confidence interval: 0.20-1.11; risk difference: -18.1%, 95% confidence interval: -39.5 to 3.3%). " 04/01/2004 - "Prophylactic phenobarbitone is not helpful in reducing the incidence of hyper-bilirubinemia in "at risk" term neonates." 05/15/1975 - "[Clinical experiences using phenobarbital in the prevention of hyperbilirubinemia in mature newborn infants in a controlled study]." 05/01/2010 - "To evaluate the role of phenobarbitone in the management of unconjugated hyperbilirubinemia during first two weeks of life in preterm neonates. " 05/01/2010 - "Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: a systematic review and meta-analysis."
7.	ClofibrateFDA Link 11/01/1985 - "This study, added to the previous therapeutic trial performed in at term neonates, shows the efficacy of clofibrate in the preventive treatment of hyperbilirubinemia in preterm neonates. " 01/01/2012 - "A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. " 11/01/1985 - "A double blind therapeutic trial of ethyl clofibrate as a preventive treatment of hyperbilirubinemia in preterm neonates was performed in neonates of gestational ages ranging between 31 and 36 weeks. " 12/01/1981 - "[Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl)]." 02/01/2012 - "To evaluate the effect of single oral dose of 50 mg/kg clofibrate in hyperbilirubinemia of term healthy neonates in Yazd, Iran. "
8.	Intravenous Immunoglobulins (IVIG)FDA Link 01/01/2011 - "Although the patient's skin lesion improved dramatically with IVIG therapy, her hyperbilirubinemia aggravated progressively. " 01/01/1993 - "Our results suggest that IVIG administration may be efficacious in the treatment of immune hemolytic hyperbilirubinemia of the newborn but further studies are required to validate the efficacy of this treatment." 09/01/2014 - "Their efficacy and good tolerance prompt consideration of IVIg as a therapeutic adjuvant to PT in severe hemolytic hyperbilirubinemia due to ABO incompatibility." 09/01/2014 - "IVIG associated with PT reduces the need for ET and the duration of PT in newborns with hyperbilirubinemia due to ABO hemolytic disease. " 09/01/2004 - "Administration of IVIG to newborns with significant hyperbilirubinemia due to ABO hemolytic disease with positive direct Coomb's test reduces the need for exchange transfusion without producing immediate adverse effects."
9.	Glycerol (Glycerine)FDA LinkGeneric 10/01/2014 - "Functional significance of HIRI-induced renal "preconditioning" was indicated by the following: 1) HIRI conferred virtually complete morphologic protection against glycerol-induced AKI (in the absence of hyperbilirubinemia) and 2) HIRI-induced TLR4 upregulation led to a renal endotoxin hyperresponsive state (excess TNF-α/MCP-1 gene induction). " 03/01/2014 - "The aim of the present study was to investigate safety and efficacy of billinaster drop and glycerin suppository in hyperbilirubinemia of healthy term newborns who had passage of first meconium. "
10.	DNA (Deoxyribonucleic Acid)IBA 08/15/2014 - "Genotyping of five SNPs in two candidate genes was performed in 126 infants with hyperbilirubinemia and 181 controls by PCR-RFLP, Gene Scan analysis and direct DNA sequencing. " 05/01/2014 - "Total genomic DNA was extracted from the blood of 100 neonates with hyperbilirubinemia (case group) and 100 neonates without hyperbilirubinemia (control group), all of whom were selected from Guangxi Heiyi Zhuang population. " 01/01/2013 - "Our paper describes in detail the peculiar clinical feature found in a child with severe neonatal unconjugated hyperbilirubinemia, where DNA analysis showed a new compound heterozygosis determined by two mutations, a known (c.508_510delTTC) and a novel mutation (c.1099C>T) giving a genotype compatible with clinical picture of CNS-II. This novel genotype extends the spectrum of known UGT1A1 mutations, which, in our opinion, could be higher than that currently reported in the literature. " 07/27/2006 - "When donor candidates had hyperbilirubinemia (>1.5 mg/dl), but otherwise normal liver function tests, their genomic DNA was isolated from leukocytes. " 11/01/2005 - "Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 01/01/2014 - "This study set out to ascertain maternal experience and satisfaction with a novel treatment of infants with significant hyperbilirubinemia using filtered sunlight phototherapy (FSPT) in a tropical setting with irregular access to effective conventional phototherapy. " 05/01/2007 - "Our results demonstrate that the efficacy of Super LED phototherapy for treating hyperbilirubinemia in premature infants was significantly better than halogen phototherapy." 02/01/2000 - "The efficacy of double phototherapy, in the form of conventional phototherapy with special blue light plus fiberoptic phototherapy, was compared with conventional phototherapy consisting of special blue lamps alone in a relatively larger series of term newborns with significant hyperbilirubinemia. " 02/01/1992 - "The latencies of peak V and interpeaks I-V and III-V in the brain-stem auditory evoked response of infants with hyperbilirubinemia before phototherapy were significantly greater than those in a control group of infants. " 02/01/1991 - "These findings suggest that high-dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune haemolytic disease resistant to phototherapy."
2.	Liver Transplantation 12/01/1990 - "During clinical follow-up the recurrence or persistence of hyperbilirubinemia along with deteriorating results of coagulation studies indicated the need for liver transplantation because of imminent poor outcome. " 11/01/2013 - "Safety of transarterial chemoembolization as bridging therapy in HCC patients with hyperbilirubinemia on the waiting list for liver transplantation: a centre experience." 09/01/2013 - "Hyperbilirubinemia after liver transplantation: the role of coupled plasma filtration adsorption." 05/01/2013 - "The outcomes of patients with severe hyperbilirubinemia following living donor liver transplantation." 01/01/2013 - "We examined the mechanisms of AHF-associated AKI, which is characterized by AKI in AHF and hyperbilirubinemia, following DA-to-Lewis rat liver transplantation. "
3.	Plasma Exchange 11/01/1986 - "Our clinical data suggested that plasma exchange using Evaflux-2A and an albumin-added electrolyte solution as the substitute fluid was useful in the treatment of hyperbilirubinemia." 01/01/1991 - "This study was undertaken to assort the group of posthepatectomy hyperbilirubinemia by occurring time for helping elucidate its indication of plasma exchange (PE). " 03/01/2015 - "Plasma exchange as a treatment for hyperbilirubinemia in 2 foals with neonatal isoerythrolysis." 06/01/2013 - "Plasma exchange (PE) for hyperbilirubinemia is not a pathogenesis oriented therapy but strives for the opportunity to cure. " 06/01/2013 - "Treatment with plasma exchange may serve benefical effect in patients with severe hyperbilirubinemia: a single center experience."
4.	Transplants (Transplant) 05/01/2013 - "The purpose of this study was to investigate the risk factors for hyperbilirubinemia following LDLT and to identify predictors of the outcomes in patients with post-transplant hyperbilirubinemia. " 05/01/2013 - "The use of a partial liver graft from an aged donor is a significant risk factor for severe hyperbilirubinemia and a poorer outcome. " 05/01/2013 - "He progressively lost transplant function, accompanied by a continuous increase in bilirubinemia. " 01/01/2013 - "Age, graft/donor weight, operative time, and blood loss were significantly associated with the risk of hyperbilirubinemia upon logistic regression analysis. " 09/01/2012 - "Inclusion of the MHV trunk or MHV tributary reconstruction influences segmental liver regeneration and preclude transient hyperbilirubinemia in the early post-liver transplant phase."
5.	Transplantation (Transplant Recipients) 01/01/1992 - "In previous studies we demonstrated that transplantation of microencapsulated hepatocytes could correct congenital hyperbilirubinemia in Gunn rats for 4 to 6 wks. " 07/14/2015 - "Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes." 06/01/2015 - "Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat." 09/01/2013 - "CPFA deserves attention as a potential inexpensive short-lasting device to treat hyperbilirubinemia after liver surgery or transplantation. " 03/01/2012 - "Therefore, we looked for the presence of A(TA)(7) TAA alleles in pediatric liver transplant recipients with unconjugated hyperbilirubinemia. "