Hydroxyprostaglandin Dehydrogenases (Hydroxyprostaglandin Dehydrogenase)

Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.

Also Known As:

Hydroxyprostaglandin Dehydrogenase; Prostacyclin Dehydrogenase; Dehydrogenase, Hydroxyprostaglandin; Dehydrogenase, Prostacyclin; Dehydrogenases, Hydroxyprostaglandin

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Hydroxyprostaglandin Dehydrogenases: 14
        15-hydroxyprostaglandin dehydrogenase: 233
        Aldo-Keto Reductase Family 1 Member C3: 29
        prostaglandin-F synthase: 17
        15-hydroxyprostaglandin-D dehydrogenase (NADP+)
        prostaglandin-E2 9-reductase

Experts

1.	Markowitz, Sanford D: 2 articles (01/2017 - 04/2014)
2.	Dinis-Ribeiro, Mário: 1 article (01/2021)
3.	Farinha, Mónica: 1 article (01/2021)
4.	Lopes, Catarina: 1 article (01/2021)
5.	Medeiros, Rui: 1 article (01/2021)
6.	Pereira, Carina: 1 article (01/2021)
7.	Cui, Lijia: 1 article (01/2018)
8.	Dong, Jin: 1 article (01/2018)
9.	Hou, Yanfang: 1 article (01/2018)
10.	Jiang, Yan: 1 article (01/2018)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2011 - "Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk." 02/01/2011 - "A recent study examined associations of tagging single nucleotide polymorphisms (tagSNPs) in 43 fatty acid metabolism-related genes and risk of colorectal cancer (CRC), showing rs8752, rs2612656 and a haplotype [comprising both of the single nucleotide polymorphisms (SNPs)] in the hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) gene to be positively associated with CRC risk. " 04/23/2014 - "Hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide) (15-PGDH, HPGD) is down-regulated in colorectal cancers and functions as a metabolic antagonist of PTGS2. "
2.	Neoplasms (Cancer) 10/11/2016 - "While an increase in the expression of Cyclooxygenase (COX)-2, and reduced expression of the tumor suppressive 15-PGDH were observed in WT-mice throughout the experimental periods, the expression of Hydroxyprostaglandin dehydrogenase (15-PGDH) was preserved in Fat-1-TG-mice. " 10/01/2007 - "Inflammation-related metabolic and catabolic enzymes (prostaglandin E(2) synthase, prostaglandin I(2) synthase and 15-hydroxyprostaglandin dehydrogenase), cell-surface receptors (E-type prostaglandin receptors) and transcription factors (ZEB1, SNAIL, PPARs, STATs and NF-kappaB) are differentially expressed in lung cancer cells compared with normal lung epithelial cells and, thus, may contribute to tumor initiation and progression. "
3.	Inflammation (Inflammations) 09/01/1991 - "These findings support the role 3 alpha-HSD in inflammation and suggest that hydroxysteroid dehydrogenases, hydroxyprostaglandin dehydrogenases and prostaglandin F2 alpha synthase may be members of a common gene family." 10/01/2007 - "Inflammation-related metabolic and catabolic enzymes (prostaglandin E(2) synthase, prostaglandin I(2) synthase and 15-hydroxyprostaglandin dehydrogenase), cell-surface receptors (E-type prostaglandin receptors) and transcription factors (ZEB1, SNAIL, PPARs, STATs and NF-kappaB) are differentially expressed in lung cancer cells compared with normal lung epithelial cells and, thus, may contribute to tumor initiation and progression. "
4.	Carcinogenesis 12/01/2010 - "Array analysis showed significant increases in the expression of 27 genes and 3 expressed sequence tags (ESTs), and decreases in 182 genes and 9 ESTs, including HIG1 domain family, member 1B, S100 calcium binding protein A9, angiopoietin 2, interleukin 8, hydroxyprostaglandin dehydrogenase 15-(NAD), suppression of tumorigenicity18, and WNT inhibitory factor 1. Pathway analysis showed that the P53 and GnRH signaling pathways may play an important role in tumorigenesis of prolactinomas. "
5.	Prolactinoma (Prolactinomas) 12/01/2010 - "Array analysis showed significant increases in the expression of 27 genes and 3 expressed sequence tags (ESTs), and decreases in 182 genes and 9 ESTs, including HIG1 domain family, member 1B, S100 calcium binding protein A9, angiopoietin 2, interleukin 8, hydroxyprostaglandin dehydrogenase 15-(NAD), suppression of tumorigenicity18, and WNT inhibitory factor 1. Pathway analysis showed that the P53 and GnRH signaling pathways may play an important role in tumorigenesis of prolactinomas. "

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)
2.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3.	Cyclooxygenase 2 (Cyclooxygenase-2)
4.	Enzymes
5.	Organic Anion Transporters
6.	Interleukin-8 (Interleukin 8)
7.	Dinoprostone (PGE2)
8.	Prostaglandins
9.	NAD (NADH)
10.	Calcium-Binding Proteins