Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)

Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.

Also Known As:

HMG CoA Reductase; Hydroxymethylglutaryl CoA Reductase; 3-Hydroxy-3-methylglutaryl CoA Reductase; 3 Hydroxy 3 methylglutaryl CoA Reductase; CoA Reductase, 3-Hydroxy-3-methylglutaryl; Reductase, 3-Hydroxy-3-methylglutaryl CoA; HMG CoA Reductases

Networked: 856 relevant articles (41 outcomes, 94 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        3-Hydroxyacyl CoA Dehydrogenases
        Hydroxymethylglutaryl CoA Reductases: 856
        human HMGCR protein
        mouse Hmgcr protein
        NAD-Dependent Hydroxymethylglutaryl-CoA Reductases
        NADP-dependent Hydroxymethylglutaryl-CoA-Reductases
        S cerevisiae HMG2 protein

Experts

1.	Kurup, Parameswara Achutha: 8 articles (11/2003 - 07/2002)
2.	Kurup, Ravi Kumar: 8 articles (11/2003 - 07/2002)
3.	Mammen, Andrew L: 7 articles (01/2019 - 11/2012)
4.	Mo, Huanbiao: 7 articles (05/2017 - 07/2004)
5.	Borgquist, Signe: 6 articles (01/2015 - 01/2008)
6.	Jirström, Karin: 6 articles (01/2015 - 01/2008)
7.	Vaziri, Nosratola D: 6 articles (01/2013 - 05/2002)
8.	Porter, Todd D: 5 articles (12/2012 - 03/2005)
9.	Shefer, S: 5 articles (12/2001 - 02/2000)
10.	Dimitroulakos, Jim: 4 articles (11/2014 - 07/2002)

Related Diseases

1.	Hypercholesterolemia 04/01/1994 - "The aim of this study was to evaluate in patients with primary hypercholesterolemia the consequences of an effective of chronic treatment with inhibitor of HMG-CoA reductase on vascular responsiveness to cold pressure test. " 01/01/2015 - "HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia." 12/01/2013 - "Immunohistochemistry for HMG-CoA reductase thought to be useful in the diagnosis of paraneoplastic hypercholesterolemia. " 12/01/2013 - "In contrast, HCC tissues derived from patients without paraneoplastic hypercholesterolemia showed only slight expression of HMG-CoA reductase whereas surrounding non-tumorous hepatocytes showed a clear expression of HMG-CoA reductase. " 01/01/2010 - "Age-Related Hypercholesterolemia and HMG-CoA Reductase Dysregulation: Sex Does Matter (A Gender Perspective)."
2.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/1989 - "If long-term safety remains good and clinical efficacy as demonstrated by reduction of cardiovascular events is proven, the HMG-CoA reductase class of agents will be a significant advance in the treatment of cardiovascular disease." 06/01/2008 - "Emerging evidence suggests that clinically important antiinflammatory effects of HMG-CoA reductase inhibition may extend beyond cardiovascular disease to other inflammatory disorders, such as rheumatoid arthritis (RA). " 11/01/2011 - "On the basis of large randomized clinical trials, pharmacological antagonists of HMG-CoA reductase (statins) have become increasingly used in clinical practice for the prevention of cardiovascular disease. " 07/01/2003 - "Here, I describe the discovery and development of lovastatin--the first approved inhibitor of HMG-CoA reductase--and the clinical trials that have provided the evidence for the ability of drugs in this class to reduce the morbidity and mortality associated with cardiovascular disease." 05/01/2008 - "Statins, the inhibitors of HMG-CoA reductase, are currently among the most commonly prescribed agents for the prevention of cardiovascular disease. "
3.	Stroke (Strokes) 01/01/2014 - "Our data support the idea that HMG-CoA reductase inhibition promotes brain remodeling and plasticity far beyond the acute stroke phase, resulting in neurological recovery. " 01/01/2014 - "In view of these observations, we were interested whether HMG-CoA reductase inhibition in the post-acute stroke phase promotes neurological recovery, peri-lesional, and contralesional neuronal plasticity. " 01/19/1999 - "The role of lipid modification in stroke prevention is controversial, although increasing evidence suggests that HMG-CoA reductase inhibition may reduce cerebrovascular events in patients with prevalent coronary artery disease. " 03/01/2005 - "Besides aspirin several new drugs for inhibition of platelet aggregation and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition are used in secondary stroke prevention. " 01/01/2020 - "This study also provided evidence of biomarkers involved in hemorrhage stroke and improved understanding of the effects of HMG-COA reductase inhibition on vascular permeability and cerebral hemorrhage."
4.	Inflammation (Inflammations) 06/01/2013 - "RSV pretreatment was associated with more Treg accumulation, less inflammatory response, and myocardial injury, suggesting that such cardioprotection against IRI was partially mediated by Treg-negative modulation of inflammation response, probably through the HMG-CoA reductase pathway." 01/01/2007 - "The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation." 08/01/2006 - "Additionally, the association of such sub-clinical inflammation with HMG-CoA reductase gene expression was evaluated. " 01/01/2020 - "Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice." 06/01/2008 - "Our results suggest that inhibition of HMG-CoA reductase may be therapeutically useful in preserving periarticular bone in RA joints via suppression of inflammation-induced bone resorption."
5.	Hyperlipidemias (Hyperlipidemia) 07/30/2022 - "Taken together, this study demonstrates the hypolipidemic potency of SI in ameliorating hyperlipidemia and its associated complications, facilitated by the inhibition of HMG-CoA reductase activity." 01/01/2015 - "However, supplementation with GOH counteracted the hyperlipidemia by inhibiting HMG CoA reductase and suppressing lipogenesis. " 09/01/2012 - "High-LMPP treatment significantly reduced the HMG-CoA reductase expression by 56.5% in the liver compared with hyperlipidemia model group. " 10/01/2007 - "These findings suggest that PT can improve hyperlipidemia, and the hypolipidemic effect may be due to HMG-CoA reductase." 12/01/2000 - "Inhibition of HMG-CoA reductase is an accepted therapy for hyperlipidemias. "

Related Drugs and Biologics

1.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2.	Cholesterol
3.	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
4.	Enzymes
5.	oxidized low density lipoprotein
6.	Biomarkers (Surrogate Marker)
7.	Coenzyme A (CoA)
8.	Lipids
9.	Simvastatin (Zocor)
10.	Lovastatin (Mevacor)

Related Therapies and Procedures

1.	Secondary Prevention
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)