Hydroxyeicosatetraenoic Acids (HETE)

Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.

Also Known As:

Networked: 318 relevant articles (6 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Daling: 20 articles (10/2018 - 06/2008)
2.	El-Kadi, Ayman O S: 11 articles (01/2022 - 10/2015)
3.	Falck, John R: 10 articles (01/2020 - 04/2005)
4.	Ma, Cui: 8 articles (08/2021 - 10/2012)
5.	Maayah, Zaid H: 7 articles (12/2018 - 10/2015)
6.	Yu, Xiufeng: 7 articles (10/2018 - 01/2013)
7.	Shen, Tingting: 6 articles (09/2015 - 10/2012)
8.	Zhang, Lei: 6 articles (08/2014 - 09/2010)
9.	Roman, Richard J: 5 articles (01/2022 - 04/2005)
10.	Abdelhamid, Ghada: 5 articles (01/2018 - 10/2015)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2020 - "If DWI-heterogeneous, an assessment of intratumoral SI on T2WI was performed: tumors with intratumoral high/low SI on T2WI were classified as Hete-H/Hete-L, respectively. " 01/01/2020 - "Targeting the 20-HETE/GPR75 pathway is a promising and novel approach to interfere with prostate tumor cell malignant progression." 01/01/2016 - "The results from our XVMC dose calculations for head and neck SRT patients indicate small to moderate underdosing of the tumor volume when compared to PB-hete calculation. " 01/01/2009 - "New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development." 02/01/2007 - "Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle."
2.	Fatty Liver 01/01/2014 - "The aim of the study was to perform isomeric analysis of hydroxyeicosatetraenoic acid (HETE) in blood samples from obese patients with non-alcoholic (NASH) and alcoholic (ASH) steatohepatitis. " 09/01/2015 - "A significant reduction in the analyzed eicosanoids and a parallel reduction in fatty liver confirmed the usefulness of HETE and HODE in the assessment of NAFLD." 01/01/2022 - "Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress-derived 8,12-iso-iPF2α -VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. "
3.	Inflammation (Inflammations) 08/12/2022 - "We observed that inflammation causes a significant imbalance in cardioprotective RAS components like ACE2, AT2R, and Ang 1-7 and increases the ArA inflammatory metabolites like hydroxyeicosatetraenoic acids (HETEs). " 12/01/1989 - "hydroxyeicosatetraenoic acids, (HETEs)] are associated with inflammation and, therefore, may play a role in HSV-1 infection and reactivation. " 12/07/2020 - "In the metabolome analysis, the changes in corticosterones, leukotrienes, and hydroxyeicosatetraenoic acids, markers of inflammation, showed a pattern similar to that of the plasma GC level. " 01/01/2012 - "CYP4A- and CYP4F-derived 20- HETE is also a proinflammatory mediator of endotoxin-induced acute systemic inflammation. " 02/01/2001 - "Increased production of 12-hydroxyeicosatetraenoic acid [12(R)-HETE] and 12-hydroxyeicosatrienoic acid [12(R)-HETrE] positively correlates with the in vivo progression of ocular surface inflammation in rabbits. "
4.	Fibrosis (Cirrhosis) 02/01/2014 - "The 15-LO/15-HETE induced adventitia fibrosis and fibroblasts phenotypic alterations depended on signaling of the transforming growth factor-β1 (TGF-β1)/Smad2/3 pathway. " 08/25/2021 - "Under hypoxia condition, 15-LO/15-HETE induces pulmonary artery contraction, promotes the proliferation of PAECs and PASMCs, inhibits apoptosis of PASMCs, promotes fibrosis of pulmonary vessels, and then leads to the occurrence of PAH. " 02/01/2014 - "15-LO/15-HETE mediated vascular adventitia fibrosis via p38 MAPK-dependent TGF-β." 04/01/1998 - "Cytochrome P450 products and renal function in cirrhosis: the HETE is on." 01/01/2022 - "The main metabolic pathways affected in patients with decompensated cirrhosis were those related to lipid metabolism, involving acylcarnitines, stearic acid derivatives, and 12/15 HETE-GABA. "
5.	Non-alcoholic Fatty Liver Disease 12/01/2020 - "Mean plasma levels of four pro-inflammatory oxylipins (Tetranor 12-HETE, 20-HETE, 8-HETrE, and 7-HDoHE) were significantly elevated in NAFLD patients compared to healthy controls. " 09/01/2015 - "A significant reduction in the analyzed eicosanoids and a parallel reduction in fatty liver confirmed the usefulness of HETE and HODE in the assessment of NAFLD." 05/09/2023 - "Inflamed adipose tissue (AT) contributes to the progression and development of NAFLD and oxylipins such as hydroxyeicosatetraenoic acids (HETE), hydroxydocosahexanenoic acids (HDHA), prostaglandins (PEG2), and isoprostanoids (IsoP), which all may play a role in AT homeostasis and inflammation. "

Related Drugs and Biologics

1.	Acids
2.	Arachidonic Acid (Vitamin F)
3.	Eicosanoids
4.	Oxylipins
5.	Leukotriene B4
6.	Lipids
7.	Eicosapentaenoic Acid
8.	Inflammation Mediators
9.	Sphingolipids
10.	Collagen

Related Therapies and Procedures

1.	Radiotherapy
2.	Re-Irradiation
3.	Therapeutics
4.	Photopheresis
5.	Ovariectomy (Oophorectomy)