Hydroxycholesterols

Cholesterol which is substituted by a hydroxy group in any position.

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        Cholesterol: 67133
        Oxysterols: 812
        Hydroxycholesterols: 5
        27-hydroxycholesterol: 168
        25-hydroxycholesterol: 150
        24-hydroxycholesterol: 93
        cholest-5-en-3 beta,7 alpha-diol: 72
        22-hydroxycholesterol: 16
        cholest-5-ene-3 beta,26-diol: 12
        25-hydroxycholesterol 3-sulfate: 6
        7-hydroxycholesteryl-3-oleate: 3
        cholest-5-ene-3,4-diol: 2
        JB 69: 2
        19-hydroxycholesterol: 1
        20-hydroxycholesterol: 1
        3-(7 beta-hydroxycholesteryl) 5'-thymidylyl monophosphate: 1
        5-cholestene-3 beta,12 alpha-diol: 1
        JC 40: 1
        (22R,23R,24S)-22,23-dihydroxy-24-methyl-5alpha-cholest-2-en-6-one
        (22R,23R,24S)-22,23-dihydroxy-2alpha,3alpha-epoxy-24-methyl-5alpha-cholest-6-one
        (25R)-5alpha-cholesta-3beta,16alpha,26-triol
        (delta5,6-3-oxynorcholenyl)dimethylcarbinol
        1 alpha,25-dihydroxycholesterol
        20,21-dihydroxycholesterol
        20,22-dihydroxycholesterol
        22-hydroxy-25-fluorocholesterol
        22-hydroxy-25-methylcholesterol
        23,25-dihydroxy-23-methyl-21-norcholesterol
        24-methylenecholest-5-en-1,3,7-triol
        24-norcholest-23-ene-3,7,12-triol
        24-vinyl-cholest-9-ene-3beta,24-diol
        25,25-difluoro-27-nor-26-hydroxycholesterol
        26-hydroxycholesterol disulfate
        4'-O-acetyl-3-O-(beta-D-arabino-pyranosyl-oxy)-cholest-5-ene-3beta,19-diol
        5,6-epoxy-24-methylenecholesta-1,3,7-triol
        5-cholesten-3,25-diol 3-sulfonate
        7 beta-hydroxycholesterol-bis-hemisuccinate-diethanolaminoate
        7,25-dihydroxycholesterol
        7-hydroxycholesterol-3,7-bis(hemisuccinate)
        7-hydroxycholesterol-3-stearate
        7beta-hydroxycholesterol-1beta-carboxylic acid
        cholest-4,7-diene-3,5,15 triol
        cholest-5-ene-3,7,22-triol
        cholest-5-ene-3,7,27-triol
        cholest-7,24-diene-3,4,22-triol
        cholest-7-ene-3,5,6 triol
        cholest-8(14)-en-3,5-diol
        cholest-8(14)-ene-3,15,26-triol
      - Cholestenes
        Cholesterol: 67133
        Oxysterols: 812
        Hydroxycholesterols: 5
        27-hydroxycholesterol: 168
        25-hydroxycholesterol: 150
        24-hydroxycholesterol: 93
        cholest-5-en-3 beta,7 alpha-diol: 72
        22-hydroxycholesterol: 16
        cholest-5-ene-3 beta,26-diol: 12
        25-hydroxycholesterol 3-sulfate: 6
        7-hydroxycholesteryl-3-oleate: 3
        cholest-5-ene-3,4-diol: 2
        JB 69: 2
        19-hydroxycholesterol: 1
        20-hydroxycholesterol: 1
        3-(7 beta-hydroxycholesteryl) 5'-thymidylyl monophosphate: 1
        5-cholestene-3 beta,12 alpha-diol: 1
        JC 40: 1
        (22R,23R,24S)-22,23-dihydroxy-24-methyl-5alpha-cholest-2-en-6-one
        (22R,23R,24S)-22,23-dihydroxy-2alpha,3alpha-epoxy-24-methyl-5alpha-cholest-6-one
        (25R)-5alpha-cholesta-3beta,16alpha,26-triol
        (delta5,6-3-oxynorcholenyl)dimethylcarbinol
        1 alpha,25-dihydroxycholesterol
        20,21-dihydroxycholesterol
        20,22-dihydroxycholesterol
        22-hydroxy-25-fluorocholesterol
        22-hydroxy-25-methylcholesterol
        23,25-dihydroxy-23-methyl-21-norcholesterol
        24-methylenecholest-5-en-1,3,7-triol
        24-norcholest-23-ene-3,7,12-triol
        24-vinyl-cholest-9-ene-3beta,24-diol
        25,25-difluoro-27-nor-26-hydroxycholesterol
        26-hydroxycholesterol disulfate
        4'-O-acetyl-3-O-(beta-D-arabino-pyranosyl-oxy)-cholest-5-ene-3beta,19-diol
        5,6-epoxy-24-methylenecholesta-1,3,7-triol
        5-cholesten-3,25-diol 3-sulfonate
        7 beta-hydroxycholesterol-bis-hemisuccinate-diethanolaminoate
        7,25-dihydroxycholesterol
        7-hydroxycholesterol-3,7-bis(hemisuccinate)
        7-hydroxycholesterol-3-stearate
        7beta-hydroxycholesterol-1beta-carboxylic acid
        cholest-4,7-diene-3,5,15 triol
        cholest-5-ene-3,7,22-triol
        cholest-5-ene-3,7,27-triol
        cholest-7,24-diene-3,4,22-triol
        cholest-7-ene-3,5,6 triol
        cholest-8(14)-en-3,5-diol
        cholest-8(14)-ene-3,15,26-triol
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - Cholesterol: 67133
      - Oxysterols: 812
        Hydroxycholesterols: 5
        27-hydroxycholesterol: 168
        25-hydroxycholesterol: 150
        24-hydroxycholesterol: 93
        cholest-5-en-3 beta,7 alpha-diol: 72
        22-hydroxycholesterol: 16
        cholest-5-ene-3 beta,26-diol: 12
        25-hydroxycholesterol 3-sulfate: 6
        7-hydroxycholesteryl-3-oleate: 3
        cholest-5-ene-3,4-diol: 2
        JB 69: 2
        19-hydroxycholesterol: 1
        20-hydroxycholesterol: 1
        3-(7 beta-hydroxycholesteryl) 5'-thymidylyl monophosphate: 1
        5-cholestene-3 beta,12 alpha-diol: 1
        JC 40: 1
        (22R,23R,24S)-22,23-dihydroxy-24-methyl-5alpha-cholest-2-en-6-one
        (22R,23R,24S)-22,23-dihydroxy-2alpha,3alpha-epoxy-24-methyl-5alpha-cholest-6-one
        (25R)-5alpha-cholesta-3beta,16alpha,26-triol
        (delta5,6-3-oxynorcholenyl)dimethylcarbinol
        1 alpha,25-dihydroxycholesterol
        20,21-dihydroxycholesterol
        20,22-dihydroxycholesterol
        22-hydroxy-25-fluorocholesterol
        22-hydroxy-25-methylcholesterol
        23,25-dihydroxy-23-methyl-21-norcholesterol
        24-methylenecholest-5-en-1,3,7-triol
        24-norcholest-23-ene-3,7,12-triol
        24-vinyl-cholest-9-ene-3beta,24-diol
        25,25-difluoro-27-nor-26-hydroxycholesterol
        26-hydroxycholesterol disulfate
        4'-O-acetyl-3-O-(beta-D-arabino-pyranosyl-oxy)-cholest-5-ene-3beta,19-diol
        5,6-epoxy-24-methylenecholesta-1,3,7-triol
        5-cholesten-3,25-diol 3-sulfonate
        7 beta-hydroxycholesterol-bis-hemisuccinate-diethanolaminoate
        7,25-dihydroxycholesterol
        7-hydroxycholesterol-3,7-bis(hemisuccinate)
        7-hydroxycholesterol-3-stearate
        7beta-hydroxycholesterol-1beta-carboxylic acid
        cholest-4,7-diene-3,5,15 triol
        cholest-5-ene-3,7,22-triol
        cholest-5-ene-3,7,27-triol
        cholest-7,24-diene-3,4,22-triol
        cholest-7-ene-3,5,6 triol
        cholest-8(14)-en-3,5-diol
        cholest-8(14)-ene-3,15,26-triol

Experts

1.	Cha, Eunju: 2 articles (02/2017 - 01/2016)
2.	Kim, Sung-Min: 2 articles (02/2017 - 01/2016)
3.	Lee, Jaeick: 2 articles (02/2017 - 01/2016)
4.	Lee, Kang Mi: 2 articles (02/2017 - 01/2016)
5.	Lee, Kwang-Woo: 2 articles (02/2017 - 01/2016)
6.	Park, Kyung Seok: 2 articles (02/2017 - 01/2016)
7.	Chen, Joy J: 1 article (01/2021)
8.	Cioccoloni, Giorgia: 1 article (01/2021)
9.	Henn, Madeline A: 1 article (01/2021)
10.	Hughes, Thomas A: 1 article (01/2021)

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/14/2017 - "This study aimed to evaluate the levels of three major hydroxycholesterols (24-, 25-, and 27-hydroxycholesterols) in the serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS), as well as to show their role in the pathogenesis of ALS experimental models. "
2.	Triple Negative Breast Neoplasms 01/01/2021 - "Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer."
3.	Hereditary Spastic Paraplegia 12/15/2020 - "Elevated hydroxycholesterols in Norwegian patients with hereditary spastic paraplegia SPG5."
4.	Liver Diseases (Liver Disease) 08/01/2004 - "Topics discussed are bile acids in human bile and feces, bile acid production, bacterial dehydroxylation of bile acids and steroids during the enterohepatic circulation, profiles of steroid sulfates in plasma of humans and other primates, development of neutral and ion-exchanging lipophilic derivatives of Sephadex for sample preparation and group separation of steroid and bile acid conjugates, profiles of steroids and bile acids in human urine under different conditions, hydroxylation of bile acids in liver disease, effects of alcohol-induced redox changes on steroid synthesis and metabolism, alcohol-induced changes of bile acid biosynthesis, compartmentation of bile acid synthesis studied with 3H-labeled ethanol, formation and metabolism of sulfated metabolites of progesterone in human pregnancy, abnormal patterns of these in patients with intrahepatic cholestasis of pregnancy corrected by ursodeoxycholic acid, inherited and acquired defects of bile acid biosynthesis and their treatment, conjugation of bile acids and steroids with N-acetylglucosamine, sulfate-glucuronide double conjugates of hydroxycholesterols, extrahepatic 7alpha-hydroxylation and 3-dehydrogenation of hydroxycholesterols, and extrahepatic formation of C27 bile acids. "
5.	Inflammation (Inflammations) 01/01/2016 - "Hydroxycholesterols (OHCs), metabolites of CNS cholesterol, are involved in diverse cellular responses to inflammation and demyelination, and may also be involved in the pathogenesis of NMO. "

Related Drugs and Biologics

1.	Glucuronides
2.	Ursodeoxycholic Acid (Urso)
3.	Sulfates (Sulfates, Inorganic)
4.	Steroids
5.	Progesterone
6.	Cholesterol
7.	Bile Acids and Salts (Bile Acids)
8.	Ethanol (Ethyl Alcohol)
9.	Acetylglucosamine
10.	Liver X Receptors