Hydroxybutyrate Dehydrogenase (3 Hydroxybutyrate Dehydrogenase)

Also Known As:

3 Hydroxybutyrate Dehydrogenase; 3-Hydroxybutyrate Dehydrogenase; D-3-Hydroxybutyrate Dehydrogenase; D-beta-Hydroxybutyrate Dehydrogenase; D 3 Hydroxybutyrate Dehydrogenase; D beta Hydroxybutyrate Dehydrogenase; Dehydrogenase, 3-Hydroxybutyrate; Dehydrogenase, D-3-Hydroxybutyrate; Dehydrogenase, D-beta-Hydroxybutyrate; Dehydrogenase, Hydroxybutyrate; (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

Networked: 88 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Hydroxybutyrate Dehydrogenase: 88
        2-hydroxybutyrate dehydrogenase: 82
        4-hydroxybutyrate dehydrogenase: 3
        E coli YihU protein
        human BDH2 protein
        succinate semialdehyde reductase
        zebrafish Bdh2 protein

Experts

1.	Zhang, Lei: 2 articles (01/2021 - 01/2021)
2.	Zhang, Jie: 2 articles (03/2020 - 01/2018)
3.	Carru, Ciriaco: 1 article (11/2022)
4.	Mangoni, Arduino A: 1 article (11/2022)
5.	Paliogiannis, Panagiotis: 1 article (11/2022)
6.	Zinellu, Angelo: 1 article (11/2022)
7.	Cao, Fengjun: 1 article (03/2022)
8.	Mei, Xiong: 1 article (03/2022)
9.	Nie, Yongli: 1 article (03/2022)
10.	Zhu, Xueni: 1 article (03/2022)

Related Diseases

1.	Carcinoma (Carcinomatosis) 04/01/1984 - "From analysis of each tumor marker the greatest positive results were obtained with the markers beta 2-microglobulin (57.1%), lactate dehydrogenase (53.1%), and hydroxybutyrate dehydrogenase (46.2%) for patients with carcinoma of the ovary. " 01/01/1992 - "Similarly, the ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glutathione reductase and catalase to glucose-6-phosphate dehydrogenase were also significantly lower in carcinomas. " 01/01/1992 - "2. The ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glutathione reductase and catalase to lactate dehydrogenase were lower in carcinomas than in normal tissues. " 09/01/1969 - "The enzymes phosphohexose isomerase, lactate dehydrogenase, hydroxybutyrate dehydrogenase, isocitric dehydrogenase, glutamate dehydrogenase, and sorbital dehydrogenase were assayed in cases of known carcinoma of the cervix and of carcinoma in situ. "
2.	COVID-19 01/01/2021 - "At present, there is a lack of study to systematically analyze the features of hydroxybutyrate dehydrogenase (α-HBDH) in COVID-19 patients. " 11/01/2022 - "We conducted a systematic review and meta-analysis to investigate serum concentrations of hydroxybutyrate dehydrogenase (HBDH), a combined marker of myocardial and renal injury, in hospitalized COVID-19 patients with different disease severity and survival status. " 11/01/2022 - "Serum hydroxybutyrate dehydrogenase and COVID-19 severity and mortality: a systematic review and meta-analysis with meta-regression." 01/01/2021 - "Elevated α-hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID-19." 01/01/2021 - "This study aimed to investigate the effect of α-hydroxybutyrate dehydrogenase (α-HBDH) levels on disease progression and prognosis of patients with COVID-19. "
3.	Heart Failure 01/01/2017 - "Metabolic changes play important roles in human heart failure and studies imply the ketogenic enzyme β-hydroxybutyrate dehydrogenase I (BDH1) is a potential biomarker. " 11/01/2022 - "Dimethylarginine dimethylaminohydrolase 2 and 3-hydroxybutyrate dehydrogenase 1 (genes implicated in heart failure) were shown by Western Blot to be under expressed in adult females that were prenatally exposed to methamphetamine, while males were deficient in 3-Hydroxybutyrate Dehydrogenase 1 only. " 02/23/2016 - "Conversely, expression of β-hydroxybutyrate dehydrogenase 1, a key enzyme in the ketone oxidation pathway, was increased in the heart failure samples. " 03/01/2020 - "DOX induced heart failure as evidenced by increased serum creatine kinase, lactic dehydrogenase and α-hydroxybutyrate dehydrogenase, and cardiac fibrosis. "
4.	Disease Progression 01/01/2021 - "This study aimed to investigate the effect of α-hydroxybutyrate dehydrogenase (α-HBDH) levels on disease progression and prognosis of patients with COVID-19. " 09/01/2020 - "Elevated procalcitonin (HR 1.72, 95% CI 1.02-2.90), urea nitrogen (HR 1.72, 95% CI 1.21-2.43), α-hydroxybutyrate dehydrogenase (HR 3.02, 95% CI 1.26-7.21) and D-dimer (HR 2.01, 95% CI 1.12-3.58) at baseline were also associated with risk for disease progression. "
5.	Lung Neoplasms (Lung Cancer) 03/06/2023 - "The purpose of our study is to investigate the expression level and prognostic value of serum α-hydroxybutyrate dehydrogenase (α-HBDH) in lung cancer (LC) patients. " 01/01/2023 - "We found that 3-hydroxybutyrate dehydrogenase 1 (BDH1) was associated with proliferation and metastases of lung cancer. "

Related Drugs and Biologics

1.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
2.	Tumor Biomarkers (Tumor Markers)
3.	beta 2-Microglobulin (beta 2 Microglobulin)
4.	Enzymes
5.	Biomarkers (Surrogate Marker)
6.	Creatine Kinase (Creatine Phosphokinase)
7.	Aspartate Aminotransferases (Aspartate Transaminase)
8.	Transferases
9.	Coenzyme A (CoA)
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Thrombolytic Therapy
2.	Therapeutics
3.	Intraperitoneal Injections