Hydrophthalmos

Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.

Also Known As:

Networked: 62 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Glaucoma
2.	Aniridia
3.	Microcephaly
4.	Cryptorchidism (Undescended Testes)
5.	Cataract (Cataracts)

Experts

1.	Ram, Jagat: 2 articles (01/2016 - 05/2015)
2.	Busin, Massimo: 2 articles (08/2015 - 09/2013)
3.	Abdelhafez, Mohamed Ahmed: 1 article (05/2021)
4.	El Gouhary, Sameh Mohamed: 1 article (05/2021)
5.	Ghali, Ali Ahmed Ali: 1 article (05/2021)
6.	Ghoraba, Hammouda Hamdy: 1 article (05/2021)
7.	Heikal, Mohamed Amin: 1 article (05/2021)
8.	Leila, Mahmoud: 1 article (05/2021)
9.	Mansour, Hosam Othman: 1 article (05/2021)
10.	Zaky, Adel Galal: 1 article (05/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hydrophthalmos:

1.	Retinaldehyde (Retinal)IBA 05/01/1996 - "Postmortem examination of the second child revealed type II lissencephaly, buphthalmos, and undifferentiated retina with rigid retinal folds. " 07/01/2007 - "On anatomic and functional classifications the commonest causes of blindness were: corneal opacity/scarring (20.0 %), phthisis bulbi (15.2 %), refractive anomalies (11.0 %), optic nerve atrophy (9.0 %), retinal disorders (7.6 %), glaucoma/buphthalmos (7.6 %), cataract (6.9 %), microphthalmos (3.5 %), vitreous opacity (2.8 %) and aphakia (2.1 %). " 07/18/2022 - "Cases of optic disc pathologies (n=20), choroidal nevus (n=10), iris-choroidal coloboma (n=5), subconjunctival hemorrhage (n=6), non-specific retinal pigmentary change (n=4), congenital cataract (n=3), posterior synechia (n=3), iris nevus (n=3), corneal opacity (n=1), choroidal coloboma (n=1), iris coloboma (n=1), buphthalmos (n=1), anophthalmos (n=1), microphthalmia (n=1), lid hemangioma (n=1), and vitreous hemorrhage (n=1) collectively accounted for approximately 2% of all neonates. " 10/01/2014 - "Here, we demonstrated that genetic disruption of the angiopoietin/TIE2 (ANGPT/TIE2) signaling pathway results in high IOP, buphthalmos, and classic features of glaucoma, including retinal ganglion degeneration and vision loss. "
2.	SteroidsIBA 09/01/2006 - "Buphthalmos following systemic steroid treatment." 10/01/2007 - "A 3-week-old infant developed buphthalmos and glaucoma after a 1-week course of topical steroid drops. " 09/01/2006 - "We describe an infant who developed juvenile glaucoma with buphthalmos while receiving systemic steroid treatment. "
3.	Proteins (Proteins, Gene)FDA Link 07/01/2007 - "A rat mutant with hereditary buphthalmos was used to (1) determine whether the extent of RGC loss corresponds to the severity and duration of elevated intraocular pressure (IOP), (2) examine whether RGCs exposed to an elevated IOP are able to regenerate their axons in a retina culture model, and (3) analyze the proteome of the regenerating retina in order to identify putative regeneration-associated proteins. " 08/01/2001 - "For patient 1, a newborn boy with buphthalmos and an opaque cornea, a novel homozygous C/T transition in codon 355 (CGA>TGA) led to a predicted nonsense codon Arg355X truncating the protein by 188 amino acids. "
4.	Cytochrome P-450 CYP1B1IBA 04/01/1997 - "Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21."
5.	AngiopoietinsIBA 10/01/2014 - "Here, we demonstrated that genetic disruption of the angiopoietin/TIE2 (ANGPT/TIE2) signaling pathway results in high IOP, buphthalmos, and classic features of glaucoma, including retinal ganglion degeneration and vision loss. "
6.	ProteomeIBA 07/01/2007 - "A rat mutant with hereditary buphthalmos was used to (1) determine whether the extent of RGC loss corresponds to the severity and duration of elevated intraocular pressure (IOP), (2) examine whether RGCs exposed to an elevated IOP are able to regenerate their axons in a retina culture model, and (3) analyze the proteome of the regenerating retina in order to identify putative regeneration-associated proteins. "
7.	Fluorescein (Funduscein)FDA LinkGeneric 01/01/2021 - "Fluorescein stain demonstrated corneal surface lesions suggestive of exposure keratopathy subsequent to bilateral buphthalmos. "
8.	Nonsense Codon (Nonsense Mutation)IBA 08/01/2001 - "For patient 1, a newborn boy with buphthalmos and an opaque cornea, a novel homozygous C/T transition in codon 355 (CGA>TGA) led to a predicted nonsense codon Arg355X truncating the protein by 188 amino acids. "
9.	Silicone OilsIBA 05/13/2021 - "To evaluate the results of pars plana vitrectomy (PPV) and silicone oil (SO) tamponade with or without encircling scleral band for repair of rhegmatogenous retinal detachment (RRD) in children with buphthalmos. "
10.	Prostaglandins AIBA 07/01/2020 - "Based on 4 standardized clinical photographs (en face with eyes open, right and left side views with eyes open, and en face with eyes closed), 3 masked expert graders each independently selected the eye they perceived to have received unilateral PGA treatment by physical appearance alone and graded the following features relative to the other eye: (1) ocular (e.g., conjunctival hyperemia, iris heterochromia, and buphthalmos), (2) palpebral (e.g., eyelash trichomegaly, eyelash hypertrichosis, eyelid erythema, eyelid edema, eyelid hyperpigmentation, high upper eyelid crease, upper eyelid ptosis, upper and/or lower eyelid retraction, and eyelid skin atrophy with presence of telangiectasias), and (3) periorbital (e.g., superior sulcus hollowing, proptosis, enophthalmos, hypoglobus, and hyperglobus). "

Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty) 01/01/2021 - "Ab interno goniotomy combined with ab externo trabeculotomy improves the success rate of buphthalmos surgery. " 06/01/2013 - "In cases of buphthalmos the IOP must be controlled before PKP (e.g., previous trabeculotomy). " 12/01/1983 - "The authors experience has shown that trabeculectomy is an effective anti-buphthalmos operation, though the result depends to a large extent on the state of the affected eye. " 12/01/1983 - "The author presents the results of 25 trabeculectomies performed for buphthalmos. " 12/01/1983 - "[Trabeculectomy in buphthalmos]."
2.	Therapeutics 01/01/1967 - "[The use of ultrasonics in the diagnosis and assessment of the efficacy of therapy of hydrophthalmos]." 06/10/2013 - "These differences could be due to buphthalmos or due to the previous surgical and medical therapies. " 11/01/1964 - "[RESULTS OF THE SURGICAL THERAPY OF HYDROPHTHALMOS]." 11/01/1988 - "While the incidence of congenital cataract and buphthalmos has remained constant, they now only lead to blindness in a small proportion of those affected, thanks to improvements in therapy. "
3.	Neoadjuvant Therapy 11/01/2019 - "In eyes with buphthalmos and patients with risk of abandonment, neoadjuvant chemotherapy can be effective when followed by enucleation and adjuvant chemotherapy. "
4.	Adjuvant Chemotherapy 11/01/2019 - "In eyes with buphthalmos and patients with risk of abandonment, neoadjuvant chemotherapy can be effective when followed by enucleation and adjuvant chemotherapy. " 11/01/2019 - "Patients with buphthalmos and those with a perceived risk for enucleation refusal and/or abandonment were given two to three cycles of chemotherapy before scheduled enucleation followed by adjuvant chemotherapy to complete six cycles, regardless of pathology. "
5.	Ligation 10/01/2019 - "We present a 17-month-old infant with microcephaly, ocular alterations (buphthalmos, leukocoria, bilateral aniridia), scrotal hypoplasia, undescended testes and neurodevelopmental delay who underwent multiplex ligation-dependent probe amplification study for WT1, showing haploinsufficiency in the probes that hybridize to the 11p13 region, compatible with an heterozygous deletion of the gene. "