Hydrophthalmos

Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.

Also Known As:

Networked: 48 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Glaucoma
2.	Microphthalmos
3.	Corneal Opacity
4.	Cataract (Cataracts)
5.	Atrophy

Experts

1.	Busin, Massimo: 2 articles (08/2015 - 09/2013)
2.	Dada, Tanuj: 2 articles (08/2010 - 01/2010)
3.	Tanwar, Mukesh: 2 articles (08/2010 - 01/2010)
4.	Dada, Rima: 2 articles (08/2010 - 01/2010)
5.	Nahum, Yoav: 1 article (08/2015)
6.	Mimouni, Michael: 1 article (08/2015)
7.	Kaushik, Sushmita: 1 article (05/2015)
8.	Ram, Jagat: 1 article (05/2015)
9.	Raj, Srishti: 1 article (05/2015)
10.	Kaur, Savleen: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hydrophthalmos:

1.	cytochrome P-450 CYP1B1 (CYP1B1)IBA 08/01/2010 - "Hence, we decided to evaluate SWS cases with buphthalmos for 6 most prevalent CYP1B1 mutations by polymerase chain reaction-restriction-fragment length polymorphism followed by sequencing. " 08/01/2010 - "SWS with buphthalmos and gyral calcification should undergo CYP1B1 mutation analysis to identify an underlying genetic pathology for glaucoma. " 08/01/2010 - "The results from this pilot study show that SWS cases with gyral calcification, buphthalmos, and early onset glaucoma should be analyzed for CYP1B1 mutations. " 04/01/1997 - "Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21." 01/01/2010 - "This is the first study from north India reporting CYP1B1 mutations in Axenfeld-Rieger syndrome with bilateral buphthalmos and early onset glaucoma. "
2.	Axenfeld-Rieger syndromeIBA 01/01/2010 - "This is the first study from north India reporting CYP1B1 mutations in Axenfeld-Rieger syndrome with bilateral buphthalmos and early onset glaucoma. "
3.	Retinaldehyde (Retinal)IBA 05/01/1996 - "Postmortem examination of the second child revealed type II lissencephaly, buphthalmos, and undifferentiated retina with rigid retinal folds. " 10/01/2014 - "Here, we demonstrated that genetic disruption of the angiopoietin/TIE2 (ANGPT/TIE2) signaling pathway results in high IOP, buphthalmos, and classic features of glaucoma, including retinal ganglion degeneration and vision loss. " 07/01/2007 - "On anatomic and functional classifications the commonest causes of blindness were: corneal opacity/scarring (20.0 %), phthisis bulbi (15.2 %), refractive anomalies (11.0 %), optic nerve atrophy (9.0 %), retinal disorders (7.6 %), glaucoma/buphthalmos (7.6 %), cataract (6.9 %), microphthalmos (3.5 %), vitreous opacity (2.8 %) and aphakia (2.1 %). "
4.	Recklinghausen's DiseaseIBA 03/01/1969 - "[Unilateral buphthalmos and facial hemiatrophy caused by Recklinghausen's disease]." 01/01/1959 - "[Buphthalmos and facial hemi-hypertrophy during Recklinghausen's disease]."
5.	Peters anomalyIBA 12/01/2005 - "Ocular abnormalities include cataract, microphthalmia, buphthalmos, and Peters anomaly. " 08/01/1985 - "At birth he showed bilateral buphthalmos with aniridia and congenital corneal opacities, agreeing with Peters' anomaly. " 08/01/1985 - "Congenital corneal opacity (Peters' anomaly) combined with buphthalmos and aniridia."
6.	ProteomeIBA 07/01/2007 - "A rat mutant with hereditary buphthalmos was used to (1) determine whether the extent of RGC loss corresponds to the severity and duration of elevated intraocular pressure (IOP), (2) examine whether RGCs exposed to an elevated IOP are able to regenerate their axons in a retina culture model, and (3) analyze the proteome of the regenerating retina in order to identify putative regeneration-associated proteins. "
7.	Nonsense Codon (Nonsense Mutation)IBA 08/01/2001 - "For patient 1, a newborn boy with buphthalmos and an opaque cornea, a novel homozygous C/T transition in codon 355 (CGA>TGA) led to a predicted nonsense codon Arg355X truncating the protein by 188 amino acids. "
8.	Proteins (Proteins, Gene)IBA 07/01/2007 - "A rat mutant with hereditary buphthalmos was used to (1) determine whether the extent of RGC loss corresponds to the severity and duration of elevated intraocular pressure (IOP), (2) examine whether RGCs exposed to an elevated IOP are able to regenerate their axons in a retina culture model, and (3) analyze the proteome of the regenerating retina in order to identify putative regeneration-associated proteins. "
9.	ParaffinIBA 01/01/1979 - "Paraffin-embedded sections of eyes enucleated because of hydrophthalmos (23 cases) or retinoblastoma (59 cases) were examined for vascular changes within the proximal optic nerve. "
10.	MioticsIBA 11/01/1965 - "Influence of miotics, Diamox and vision occluders on light-induced buphthalmos in domestic fowl."

Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty) 06/01/2013 - "In cases of buphthalmos the IOP must be controlled before PKP (e.g., previous trabeculotomy). " 12/01/1983 - "The authors experience has shown that trabeculectomy is an effective anti-buphthalmos operation, though the result depends to a large extent on the state of the affected eye. " 12/01/1983 - "The author presents the results of 25 trabeculectomies performed for buphthalmos. " 12/01/1983 - "[Trabeculectomy in buphthalmos]." 01/01/1981 - "Evaluation of trabeculectomy in buphthalmos."
2.	Transplants (Transplant) 10/01/2010 - "DSEK using a corneal graft of 10.0-mm diameter obtained from a normal-sized donor button can be performed safely and effectively in cases of unilateral buphthalmos and secondary corneal decompensation, where a large recipient cornea requires an equivalently sized graft and transplantation of large amounts of donor endothelium." 04/01/2003 - "To evaluate the prognosis and complications of penetrating keratoplasty (PKP) for corneal decompensation in eyes with buphthalmos and to analyze the risk factors for graft failure. " 05/01/2013 - "Four eyes of 4 adults (1 man, 3 women) with bullous keratopathy and buphthalmos secondary to congenital glaucoma were treated with DMEK using posterior lamellar grafts with diameters ranging from 10 to 12 mm. The mean age was 31 (±9) years (range, 20-38 years). " 04/01/2003 - "Efficient control of IOP before and after PKP is mandatory in eyes with buphthalmos to avoid graft failure and progress of glaucomatous optic nerve atrophy."
3.	Penetrating Keratoplasty 04/01/2003 - "Penetrating keratoplasty for endothelial decompensation in eyes with buphthalmos." 04/01/2003 - "To evaluate the prognosis and complications of penetrating keratoplasty (PKP) for corneal decompensation in eyes with buphthalmos and to analyze the risk factors for graft failure. " 03/01/1995 - "After penetrating keratoplasty, the patient developed absolute glaucoma with buphthalmos, leading to enucleation. " 08/01/2015 - "The presence of buphthalmos, anterior chamber intraocular lens, aphakia, or prior penetrating keratoplasty were not risk factors for the failure of DSAEK. "
4.	Transplantation (Transplant Recipients) 06/15/1989 - "Transplantation of congenitally opaque corneas from eyes with exaggerated buphthalmos." 10/01/2010 - "DSEK using a corneal graft of 10.0-mm diameter obtained from a normal-sized donor button can be performed safely and effectively in cases of unilateral buphthalmos and secondary corneal decompensation, where a large recipient cornea requires an equivalently sized graft and transplantation of large amounts of donor endothelium."
5.	Intraocular Lenses (Intraocular Lens) 05/01/2015 - "Eight eyes of 6 children with congenital glaucoma (buphthalmos) underwent phacoaspiration with or without intraocular lens (IOL) implantation. " 08/01/2015 - "The presence of buphthalmos, anterior chamber intraocular lens, aphakia, or prior penetrating keratoplasty were not risk factors for the failure of DSAEK. "