Hydronephrosis

Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.

Also Known As:

Networked: 1924 relevant articles (113 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Renal Insufficiency (Renal Failure)
2.	Ureteral Obstruction
3.	Pain (Aches)
4.	Flank Pain
5.	Azotemia

Experts

1.	Lorenzo, Armando J: 8 articles (05/2015 - 07/2007)
2.	Tohyama, Chiharu: 8 articles (10/2014 - 05/2003)
3.	Carlström, Mattias: 6 articles (01/2016 - 07/2006)
4.	Yosypiv, Ihor V: 6 articles (04/2014 - 04/2006)
5.	Jørgensen, Troels Munch: 6 articles (12/2013 - 06/2004)
6.	Nguyen, Hiep T: 6 articles (11/2012 - 09/2004)
7.	Muslumanoglu, Ahmet Yaser: 6 articles (06/2012 - 01/2009)
8.	Braga, Luis H: 5 articles (05/2015 - 07/2007)
9.	Kubota, Yoshinobu: 5 articles (03/2015 - 01/2006)
10.	Yoshioka, Wataru: 5 articles (10/2014 - 09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hydronephrosis:

1.	CreatinineIBA 06/01/2006 - "Hydronephrosis partially improved, but her serum creatinine level further increased to 2.3 mg/dL. " 04/01/2009 - "Although the patient had right residual hydronephrosis, the creatinine level improved to 1.2 mg/dL during follow-up." 10/01/2015 - "The study clearly demonstrated that pediatric patients with hydronephrosis and dysfunction had significantly higher uNGAL to creatinine concentrations as compared with controls." 08/01/2008 - "The study included 96 adults with unilateral or bilateral chronic obstructive hydronephrosis and compromised renal function (serum creatinine >or=1.8 mg dl(-1)). " 06/01/2006 - "Six months later, ultrasonographic study did not show hydronephrosis and the serum creatinine level was 2.0 mg/dL."
2.	Tetrachlorodibenzodioxin (TCDD)IBA 06/01/2014 - "In previous studies, we established an animal model of human congenital hydronephrosis with exposure of developing mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), but the etiopathogenesis is not entirely clear. " 10/01/2014 - "Although C57BL/6J and BALB/cA mice harbor AhR receptors highly responsive to TCDD, they were found by chance to differ significantly in the incidence of TCDD-induced hydronephrosis. " 06/01/2014 - "Histochemical staining indicated that Prx I protein was positively expressed in the ureteric epithelium in the treated group, and not in the control group, which is consistent with MALDI-TOF-MS. Prx I protein may be a potential biomarker or responsive protein of hydronephrosis in fetal mice induced by TCDD." 01/01/2014 - "Elucidation of the pathway leading to the onset of hydronephrosis using the TCDD-exposed mouse model will deepen our understanding of the molecular basis of nonobstructive hydronephrosis in humans. " 06/01/2012 - "Hydronephrosis induced in the kidney of neonatal mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via lactation is a sensitive and characteristic hallmark of TCDD teratogenicity. "
3.	diazenedicarboxylic acid bis(N'-methylpiperazide)IBA 01/01/2000 - "The postoperative course was uneventful and the bilateral hydronephrosis improved markedly on DIP." 06/01/1986 - "DIP four months after the operation showed improvement of right hydronephrosis, but left hydronephrosis was observed. " 07/01/2011 - "3 months after the procedure, DIP revealed improvement of hydronephrosis (grade 1) and CT showed elongation of nutcracker distance. " 07/01/2011 - "KUB, DIP and retrograde pyelography (RP) revealed multiple renal stones, left hydronephrosis (grade 2) and ureteropelvic junction obstruction (UPJO). " 01/01/2003 - "A ureteral stone with right hydronephrosis was pointed on DIP. "
4.	Pentetic Acid (DTPA)FDA LinkGeneric 09/01/2015 - "For objective assessment, the improvement in differential renal function (DRF) and radio-tracer wash out time (T1/2) on Tc-99m DTPA scan and decrease in hydronephrosis (HDN) on renal ultrasound (USG) and urography (IVU) were assessed. " 02/01/2003 - "Diethylenetriamine pentaacetic acid renal scans documented improvement in the glomerular filtration rate from a mean of 26.4 ml. per minute after stone creation and hydronephrosis to 54.8 ml. per minute 4 to 5 weeks after laparoscopic anatrophic nephrolithotomy. " 01/01/1992 - "Follow-up studies by echography or DTPA renal scan revealed spontaneous resolution of the dilated collecting systems in these cases and confirms our belief that some hydronephrosis in neonates and infants may resolve spontaneously and may just be a manifestation of physiologic change during development. " 11/01/2008 - "Differential renal function (DRF) calculation with 99mTc-diethylenetriamine-pentaacetic acid (DTPA) or mercaptoacetyltriglycine (MAG3) is gaining clinical importance in the evaluation of patients with ureteropelvic junction obstruction with hydronephrosis (HN). " 03/01/2008 - "Diethylenetriamine pentaacetic acid and mercaptoacetyltriglycine renal scans are commonly used to evaluate infants and children with hydronephrosis to assess for changes in kidney function and drainage. "
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1981 - "They observe the rapid onset of an unilateral uretero-hydronephrosis which was due to oedema of the right vesico-ureteral junction and which was cured by a short treatment, with corticoids." 01/01/2002 - "The hydronephrosis recurred three years later, but corticosteroids were again effective in improving ureteral obstruction. " 01/01/2013 - "A CT scan of the abdomen revealed bilateral hydronephrosis secondary to retroperitoneal fibrosis, and an unruptured infrarenal abdominal aortic aneurysm Medical management with corticosteroids relieved the ureteric obstruction and renal function started to normalise within 72 h."
6.	Furosemide (Lasix)FDA LinkGeneric 09/01/2003 - "The purpose of this study was to evaluate whether some parameters of the basic renogram allow one to omit the administration of furosemide in cases of hydronephrosis. " 10/01/2001 - "The purpose of this study in rabbits was to evaluate the effect of furosemide on resistive index (RI) in the diagnosis of partial hydronephrosis. " 03/01/1999 - "The purpose of this study was to determine the diagnostic value of diuretic duplex Doppler sonography in distinguishing between obstructive and nonobstructive hydronephrosis in children by calculating the resistive indices (RI) before and after administration of furosemide. " 01/01/1987 - "Patients with hydronephrosis were assessed by furosemide intravenous urography, pressure flow studies and renography. " 01/01/1987 - "The relationship between pressure flow studies and furosemide urography in hydronephrosis."
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 10/01/2005 - "It should be considered the "gold standard" for the management of UPJ obstruction, especially in those patients with significant hydronephrosis, renal impairment or a crossing vessel. " 01/01/1999 - "To evaluate the efficacy of the vessel transposition technique in ureterovascular hydronephrosis in children. " 03/01/2004 - "Recent reports and studies further confirm earlier findings that the success rate of endopyelotomy is decreased when a crossing vessel is the primary cause of ureteropelvic junction obstruction, poor renal function and significant hydronephrosis. " 05/01/1961 - "[Clinical contribution to the study of hydronephrosis caused by an anomalous vessel]." 04/01/2015 - "Hydronephrosis: Comparison of extrinsic vessel versus intrinsic ureteropelvic junction obstruction groups and a plea against the vascular hitch procedure."
8.	ReninIBA 09/01/1983 - "Blood pressure and supine plasma renin were measured in fourteen children aged seven to eighteen years whose hydronephrosis had been relieved surgically two to eleven years previously. " 01/01/1986 - "Histological, ultrastructural, immunohistochemical, intravital microscopic and electrophysiological techniques have been applied to study experimental hydronephrosis in rats in order to assess its value as a preparation for the investigation of renal microcirculation and of the electrophysiological properties of the renin-containing juxtaglomerular (JG) cells of the afferent glomerular arteriole. " 09/15/2015 - "The kidneys of surviving mice showed the absence of renin, hypertrophic arteries, hydronephrosis, and negligible levels of plasma renin. " 09/15/2015 - "Whole body deletion of the renin gene results in severe morphological and functional derangements, including thickening of renal arterioles, hydronephrosis, and inability to concentrate the urine. " 06/01/2015 - "Hydronephrosis is characterized by substantial loss of tubules and affects renin secretion in the kidney. "
9.	AntigensIBA 11/01/2006 - "The aim of this study was to find out the predictive role of serum and urinary carbohydrate antigen 19-9 levels in benign hydronephrosis and whether these levels are helpful for differentiation of complete or partial urinary obstruction. " 01/01/2002 - "Hydronephrosis causes false-positive results when screening for malignant disease by serum carbohydrate antigen 19-9 measurement." 06/01/2015 - "The roles of serum and urinary carbohydrate antigen 19-9 in the management of patients with antenatal hydronephrosis." 07/01/2007 - "Elevation of serum and urinary carbohydrate antigen 19-9 in benign hydronephrosis." 11/01/2006 - "Benign hydronephrosis should be considered in the differential diagnosis of carbohydrate antigen 19-9 increments, as this is what is of most importance in clinical practice."
10.	CollagenIBA 03/01/2005 - "In patients with lower ratios of collagen-to-smooth muscle in the UPJ proper hydronephrosis was more improved postoperatively (p = 0.049). " 02/01/2015 - "There was proposed diagnostic coefficient of ratio between collagens types I and III in patients, suffering hydronephrosis, caused by obstruction of various etiology. " 02/01/2015 - "In patients, suffering hydronephrosis stages II-III, caused by the ureteric-pelvic segment (UPS) obstruction due to inborn failures of urinary system, the collagen types I and III ratio reduction, and in acquired obstruction--its enhancement, are noted in interstitium, renal parenchyma vessels and the UPS walls. " 01/01/2008 - "An excessive amount of collagen fibers around the muscle cells in the ureteropelvic junction could be responsible for obstruction in patients with hydronephrosis. " 09/01/1993 - "Thus, the neonatal renal response to obstruction resulted in increased amounts of a range of collagens in the interstitium and TBM, and the extent of this response was partially related to the degree of hydronephrosis."

Therapies and Procedures

1.	Stents 04/01/2001 - "Our results demonstrated that percutaneous nephrostomy is superior to ureteral stents for diversion of hydronephrosis caused by stones, especially in patients with a high temperature, as well as in males and juveniles." 01/01/2007 - "Double pigtail stent insertion is effective for the treatment of moderate or severe symptomatic hydronephrosis in pregnancy, and showed a lower failure rate than the conservative treatment. " 11/01/2004 - "Follow-up (5-14 months) radiologic studies after stent removal showed improvement in the hydronephrosis in all except one patient. " 10/01/2013 - "Degree of hydronephrosis improved (paired t test P<0.03) after stent placement for both benign and malignant cohorts. " 05/01/2013 - "Both the hydronephrosis and the symptoms were relieved by ureteral stent insertion and percutaneous nephrostomy. "
2.	Nephrectomy 12/01/2003 - "Mean interval to spontaneous resolution was 1.39 (+/- 1.41, SD) yr. Surgery was performed in 174 kidneys, including pyeloplasty in 105, ureteroneocystostomy in 23, transurethral incision in 11 and nephrectomy in 9. Most patients had initially high-grade hydronephrosis (p<0.05). " 01/01/2014 - "Hydronephrosis of the involved kidney with echogenic debris in the dilated pelvicalyceal system on ultrasonography and non-visualised kidney on intravenous urogram was the most common findings on imaging studies who underwent nephrectomy. " 11/01/2014 - "LESS retroperitoneoscopic nephrectomy for giant hydronephrosis is technically feasible and safe for selected patients. " 11/01/2014 - "Between July 2011 and April 2013, 22 patients underwent LESS retroperitoneoscopic nephrectomy for giant hydronephrosis with nonfunctioning kidneys. " 11/01/2014 - "To report our experience and assess the feasibility and safety of laparoendoscopic single-site (LESS) retroperitoneoscopic nephrectomy for giant hydronephrosis. "
3.	Drug Therapy (Chemotherapy) 03/01/1995 - "A follow-up MRI after chemotherapy demonstrated significant decrease in the size of the periureteral disease and improvement in the extent of hydronephrosis." 12/01/1996 - "Thus, chemotherapy after ureteral catheterization may be effective for patients with peritoneal dissemination and hydronephrosis." 01/01/2013 - "On univariate analysis, pathologic stage≥pT3, <10 nodes removed, positive margins, positive nodes, hydronephrosis, lymphovascular invasion, and mixed histology significantly predicted LF; node density was marginally predictive, but use of chemotherapy, number of positive nodes, type of surgical diversion, age, gender, race, smoking history, and body mass index were not. " 01/01/2010 - "The follow-up CT, after surgery and chemotherapy, showed a relapse of the lesions with hydronephrosis due to ureteral compression." 09/01/2001 - "Multivariate analysis revealed the following to have a significant association with survival: T classification (p = 0.001), lymph node involvement (p = 0.004), complete response to RT (p = 0.054), hydronephrosis (p = 0.019), and use of chemotherapy in the treatment regimen (p = 0.025). "
4.	Transplants (Transplant) 01/01/1990 - "In cases of renal graft failure with sonographic findings of perinephric fluid collection or hydronephrosis, antegrade pyelography--though more invasive--should always be performed given its low complication rate and improved visualization and pathological localization compared to other techniques. " 12/01/2014 - "Robotic-assisted laparoscopic native-to-transplant UU was performed with resultant durable improvement in the patient's hydronephrosis and kidney function. " 12/01/1988 - "This study confirms that the hydronephrosis that occurs within the first year after aortic bifurcation graft surgery is not uncommon but it is rarely of clinical significance in the asymptomatic patient." 07/01/1977 - "In renal transplant evaluation ultrasound is useful as a complementary modality to other imaging studies permitting the recognition of pelvic fluid collections, rejection, and hydronephrosis. " 04/01/2013 - "To evaluate our pediatric renal transplant patient population at the Children's Hospital of Pittsburgh to better understand the clinical significance of hydronephrosis. "
5.	Catheters 08/01/1983 - "Percutaneous nephrostomy using ultrasound guidance with the pigtail catheter is very useful in dealing with problems associated with pelvic hydronephrosis in children. " 01/01/2007 - "The hydronephrosis was improved by urethral balloon catheter. " 10/01/1984 - "[Animal experiment studies on the functional evaluation of hydronephrosis with non-catheter unilateral determination of 131I-hippuran clearance]." 01/01/1963 - "PATHOPHYSIOLOGIC STUDY OF THE GRADUAL DEVELOPMENT OF HYDRONEPHROSIS INDUCED BY PASSAGE OF GRADED SIZE CATHETERS IN DOGS." 12/01/2014 - "Hydronephrosis of the right kidney has not recurred after removing the nephrostomy catheter. "