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Hydrocodone (Dihydrocodeinone)

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Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

Also Known As:

Dihydrocodeinone; Hycodan; Hydrocodon; Codinovo; Dicodid; Du Pont Brand of Hydrocodone Tartrate; Hycon; Hydrocodone Bitartrate; Hydrocodone Tartrate (1:1), Hydrate (2:5); Knoll Brand of Hydrocodone Tartrate; Nourypharma Brand of Hydrocodone Tartrate; Robidone; Robins Brand of Hydrocodone Tartrate; Wyeth Brand of Hydrocodone Tartrate; Hydrocodeinonebitartrate; Hydrocon; Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-

Networked: 202 relevant articles (30 outcomes, 46 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Robinson, Cynthia Y: 4 articles (09/2015 - 01/2014)
2.	Wen, Warren: 4 articles (07/2015 - 06/2012)
3.	Farr, Stephen J: 3 articles (09/2015 - 01/2014)
4.	Hale, Martin E: 3 articles (09/2015 - 01/2014)
5.	He, Ellie: 3 articles (07/2015 - 01/2015)
6.	Atayee, Rabia S: 3 articles (09/2014 - 05/2012)
7.	Best, Brookie M: 3 articles (09/2014 - 05/2012)
8.	Manchikanti, Laxmaiah: 3 articles (03/2014 - 07/2005)
9.	Moore, Paul A: 3 articles (08/2013 - 05/2006)
10.	Morris, E: 3 articles (08/2000 - 05/2000)

Related Diseases

1.	Pain (Aches) 01/01/2014 - "This single-entity, extended-release formulation of hydrocodone was generally safe, well tolerated, and effective in reducing chronic pain for 48 weeks. " 07/01/2007 - "Each patient received 0-40 mg/24hrs of hydrocodone as needed for pain relief for the duration of this four week study. " 01/01/2015 - "The recent introduction of extended-release formulations of the opioid analgesic hydrocodone potentially broadened the possibility of providing pain relief for individuals for whom current formulations are either ineffective or not tolerated. " 01/01/2008 - "An additional 14.5% of the patients responded to a double dose, and the remaining 29% of patients did not experience any pain relief from hydrocodone administration. " 09/01/2015 - "Patients with chronic pain newly enrolled or rolled over from a 12-week, placebo-controlled hydrocodone ER study; 330 patients enrolled, 329 patients received study drug, and 189 completed the study. "
2.	Postoperative Pain 06/01/2015 - "Rescheduling of hydrocodone combination products: potential impact and alternatives for postoperative pain management." 04/01/2015 - "Postoperative pain management was variable, with hydrocodone and derivatives given most commonly (61%). " 01/01/2006 - "Group A (N = 50) used hydrocodone to manage postoperative pain. " 05/01/2004 - "The use of a PCA ropivacaine infusion (group I) resulted in a significant reduction of postoperative pain by 34% as measured by VAS scale (P <.05), but no changes in the amount of hydrocodone consumption. " 06/01/2004 - "Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery."
3.	Neoplasms (Cancer) 09/01/2000 - "We reviewed the pharmacy records for the use of hydrocodone for all cancer admissions to our unit from May 1996 to December 1998. " 01/01/2002 - "Hydrocodone is effective and safe to treat cough in advanced cancer A starting dose of 10 mg per day in divided doses seems effective. " 03/01/2013 - "This study sought to characterize the experience of patients taking hydrocodone for non-cancer pain. " 01/01/2013 - "The available clinical trials for the use of hydrocodone in the management of acute, chronic, and cancer pain are presented." 01/01/2002 - "This study evaluates hydrocodone for cough in advanced cancer The results presented are from a phase II study with dose titration. "
4.	Cough 02/15/2007 - "Although hydrocodone is widely used and has been shown to effectively treat cough caused by other conditions, the drug has not been studied in patients with colds. " 09/01/2004 - "Perception of cough by both the bronchoscopist and the nurse was significantly lower in the hydrocodone group (3 (0-10) and 3 (0-10)) than in the placebo group (6 (0-10) and 6 (0-10)), respectively (p = 0.001). " 09/01/2004 - "A randomised, placebo controlled, double blind study was undertaken to determine whether hydrocodone in combination with midazolan improves cough suppression during FB without increasing the risk of desaturation. " 01/01/2002 - "Cough severity, frequency, complications, and hydrocodone side effects. " 05/23/1986 - "Isolation and identification of hydrocodone in narcotic cough syrups by high-performance liquid chromatography with infrared spectrometric identification."
5.	Low Back Pain (Lumbago) 06/01/2014 - "Single-entity hydrocodone extended-release capsules in opioid-tolerant subjects with moderate-to-severe chronic low back pain: a randomized double-blind, placebo-controlled study." 01/01/2015 - "This multicenter, randomized, double-blind, placebo-controlled study with an enriched enrollment, randomized withdrawal design was conducted to evaluate the analgesic efficacy and safety of single-entity, once-daily hydrocodone 20 to 120 mg tablets (HYD) in opioid-naive and opioid-experienced patients with uncontrolled moderate to severe chronic low back pain (CLBP). " 01/01/2015 - "A multicenter, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of single-entity, once-daily hydrocodone tablets in patients with uncontrolled moderate to severe chronic low back pain." 01/01/2015 - "Efficacy and tolerability of a hydrocodone extended-release tablet formulated with abuse-deterrence technology for the treatment of moderate-to-severe chronic pain in patients with osteoarthritis or low back pain." 06/01/2015 - "This study aimed to assess the tolerability of the extended use (≤35 days) of MNK-155, a biphasic (immediate-release/extended-release) hydrocodone bitartrate/N-acetyl-p-aminophenol (acetaminophen) (IR/ER HB/APAP) 7.5/325-mg fixed-dose combination analgesic agent, in patients with chronic noncancer pain (CNCP) caused by osteoarthritis or chronic low back pain. "

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	Ibuprofen (Motrin)
3.	Codeine (Codeine Phosphate)
4.	Tablets
5.	Oxycodone (Oxycontin)
6.	Tramadol
7.	Opioid Analgesics (Opioids)
8.	Methadone (Dolophine)
9.	Analgesics (Analgesic Drugs)
10.	Narcotics (Narcotic Analgesics)

Related Therapies and Procedures

1.	Tonsillectomy
2.	Analgesia
3.	Osteotomy
4.	Episiotomy
5.	Drug Therapy (Chemotherapy)