Hydrochloric Acid (Hydrogen Chloride)

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

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Networked: 707 relevant articles (23 outcomes, 49 trials/studies)

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Drug Context: Research Results

Experts

1.	Slutsky, Arthur S: 3 articles (01/2016 - 12/2006)
2.	Attin, Thomas: 3 articles (11/2014 - 08/2008)
3.	Wiegand, Annette: 3 articles (11/2014 - 08/2008)
4.	Yoshimura, Naoki: 3 articles (01/2012 - 10/2007)
5.	Wang, Chen: 3 articles (10/2010 - 05/2006)
6.	Kubo, Keishi: 3 articles (02/2010 - 03/2004)
7.	Tsushima, Kenji: 3 articles (02/2010 - 03/2004)
8.	Koizumi, Tomonobu: 3 articles (02/2010 - 03/2004)
9.	Gruber, Michael: 3 articles (09/2009 - 02/2005)
10.	Yukawa, Nobuhiro: 2 articles (06/2015 - 04/2009)

Related Diseases

1.	Ulcer 09/01/1985 - "Tests using hydrochloric acid and a rabbit ulcer model showed the efficacy of the direct in vivo labeling technique and the ability of the tagged material to bind to ulcers, respectively. " 01/01/1970 - "[Study of the relations between some genetic factors and hydrochloric acid secretory capacity of the stomach in families with ulcers]." 12/01/2008 - "At the start, patients owe their ulcer to gastric hypersecretion of hydrochloric acid; approximately 60% may be H. " 12/01/2008 - "Hydrochloric acid, necessary for producing a DU, is strongly associated with the likelihood of an ulcer. " 01/01/2006 - "[Impact of hydrochloric acid and HP-invasion on the cavitary pressure in the duodenal and gastroesophageal region in patients with ulcer]."
2.	Lung Injury 02/01/2010 - "The present study was performed to investigate the role of exogenous surfactant on hydrochloric acid (HCL) - induced lung injury in rats. " 04/01/2005 - "This study examines surfactant dysfunction in rats with inflammatory lung injury from intratracheal instillation of hydrochloric acid (ACID, pH 1.25), small nonacidified gastric particles (SNAP), or combined acid and small gastric particles (CASP). " 03/19/2004 - "The present study was designed to clarify the effects of (-)-ethyl N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-piperazin-1-yl)ethoxy]benzoyl]-l-phenylalaninate dihydrochloride (JTE-607), a novel multiple cytokine inhibitor, on hydrochloric acid (HCl) aspiration lung injury in rats. " 08/01/2015 - "Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs." 01/01/2014 - "To investigate the role of macrophage activation in aseptic lung injury and identify molecular mediators with therapeutic potential, lung injury was induced in wild-type (WT) and Akt2(-/-) mice by hydrochloric acid aspiration. "
3.	Duodenal Ulcer (Curling's Ulcer) 01/01/1977 - "Mean bicarbonate secretion was significantly greater in the duodenal ulcer patients than in the normal subjects basally and after the lowest dose of hydrochloric acid. " 01/01/2008 - "[Effect of hydrochloric acid on cavernous pressure in the duodenogastroesphageal zone in patients with duodenal ulcer associated with Helicobacter pylori]." 02/12/1987 - "We conclude that most patients with duodenal ulcer disease have decreased proximal duodenal mucosal bicarbonate production at rest, in response to hydrochloric acid, and in relation to peak gastric acid secretion. " 07/01/1986 - "In patients with hyperacidic duodenal ulcer the hyperproduction of hydrochloric acid was shown to occur both during the nervous-reflectory and humoral phases of secretion. " 11/01/1985 - "Various amounts of hydrochloric acid (50, 100 and 200 ml) of two different concentrations (70- and 140 mmol/l) were rapidly instilled into the duodenum of eight healthy subjects and five duodenal ulcer patients. "
4.	Pulmonary Edema 10/01/1986 - "The effects of pulmonary instillation of hydrochloric acid on solute flux from the lung (measured as the clearance of 99mTcDTPA) together with an index of oedema formation (the ratio of lung wet weight to lung dry weight) was measured in rats. " 05/01/1974 - "Lung clearance of Diplococcus pneumoniae was markedly reduced in rats with acute hemorrhagic pulmonary edema produced by instillation of hydrochloric acid. " 03/01/2004 - "The bias for EVLWDI - EVLWG measurements was -5.2 mL/kg (95% confidence interval, -5.7 to -4.7 mL/kg) with 95% limits of agreement of -7 to -3.4 mL/kg. In the hydrochloric acid group, there was no significant correlation between EVLWDI and EVLWG values, and the double indicator method failed to detect pulmonary edema in 65% of the animals (EVLWDI <8 mL/kg). " 09/01/1991 - "Effect of superimposed high frequency oscillatory ventilation on pulmonary gas exchange was investigated in seven anesthetized and paralyzed dogs with pulmonary edema induced by intrapulmonary injection of hydrochloric acid. " 09/01/1991 - "[Effect of superimposed high frequency oscillation on pulmonary edema induced by intrapulmonary injection of hydrochloric acid in dogs]."
5.	Stomach Ulcer (Gastric Ulcer) 04/01/1952 - "The clinical significance of the small benign gastric ulcer with a note on benign ulcer of the greater curvature and in the absence of free hydrochloric acid." 04/01/2003 - "To identify the pathogenesis of gastric ulcers by comparing injury to the nonglandular gastric mucosa of horses caused by hydrochloric acid (HCl) or volatile fatty acids (VFAs). " 11/01/1995 - "The number of gastric ulcers, the secretion of gastric juice, hydrochloric acid (HCI), and pepsin A were detected. " 07/01/1994 - "Among 3-morpholinopropylamino derivatives, 5-isopropyl- (21) and 7-chloro-2-(3-morpholinopropyl)amino-8H-indeno[1,2-d]thiazole (25) showed a considerably stronger inhibitory behavior on hydrochloric acid-induced gastric ulcers than cetraxate hydrochloride. " 06/01/1990 - "The antiulcer activity against water-immersion stress-induced gastric ulcer, aspirin-induced gastric ulcer and gastric necrosis induced by hydrochloric acid also were tested in the rat. "

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4.	Polymyxin B (Aerosporin)
5.	Cimetidine (Biomet)
6.	Aspirin (Acetylsalicylic Acid)
7.	Taurocholic Acid (Sodium Taurocholate)
8.	Secretin
9.	Ethyl Ether (Ether)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Positive-Pressure Respiration (PEEP)
2.	Oral Administration
3.	Artificial Respiration (Mechanical Ventilation)
4.	Catheters
5.	Intravenous Injections