Polyhydramnios

A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.

Also Known As:

Networked: 606 relevant articles (11 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hydrops Fetalis (Fetal Edema)
2.	Placenta Previa
3.	Oligohydramnios
4.	Pre-Eclampsia (Preeclampsia)
5.	Hypertension (High Blood Pressure)

Experts

1.	Dreux, Sophie: 8 articles (01/2021 - 01/2006)
2.	Muller, Françoise: 6 articles (04/2017 - 01/2006)
3.	Sheiner, E: 5 articles (09/2013 - 10/2001)
4.	Mazor, M: 5 articles (02/2004 - 01/2000)
5.	Yogev, Yariv: 4 articles (12/2022 - 04/2015)
6.	Czerkiewicz, Isabelle: 4 articles (04/2017 - 08/2011)
7.	Oury, Jean-François: 4 articles (04/2017 - 03/2010)
8.	Vargas-Poussou, Rosa: 4 articles (04/2017 - 05/2009)
9.	Polak, Michel: 4 articles (03/2014 - 12/2008)
10.	Adzick, N Scott: 3 articles (10/2021 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polyhydramnios:

1.	Indomethacin (Indometacin)FDA LinkGeneric 07/01/2000 - "Indomethacin was effective in the management of hydramnios and preventing it's complications." 05/01/1996 - "However, although indomethacin appears to be effective in the treatment of polyhydramnios, our goal is to analyze efficacy and side effects, so as to define conditions of clinical use." 06/01/1992 - "After sonographic evaluation has confirmed the polyhydramnios and a determination is made of the potential etiologies, indomethacin appears to be an effective agent in reducing the amniotic fluid volume and in preventing prematurity." 11/28/1992 - "In comparative trials of indomethacin as short treatment of premature labour and polyhydramnios the drug proved to be effective. " 11/01/1991 - "This study suggests that the use of indomethacin in polyhydramnios is questionable."
2.	ProstaglandinsIBA 01/01/1987 - "Occurrence of acute polyhydramnios and severity of the anomalies showed by serial ultrasound scans has led to termination of pregnancy induced by prostaglandin E. " 01/01/1987 - "Extra-amniotic prostaglandin pregnancy termination was performed at 20 weeks' gestation due to the onset of acute hydramnios and the rapid increase in tumor size. " 10/01/1992 - "Inhibition of prostaglandin synthesis with indomethacin has been reported to be effective for prevention of labor and for treatment for symptomatic polyhydramnios. " 05/01/1984 - "Three putative functions of uterine PRL are suggested from current studies: a) a PRL receptor defect is present in the chorion laeve of patients with pregnancies complicated by chronic polyhydramnios and this deficiency in chorionic receptors for endometrial PRL may result in the development of excessive amniotic fluid; b) decidual PRL may modulate prostaglandin synthesis not only within the endometrium prior to menstruation, but also within the chorion and amnion to allow labour to proceed in a timely manner; and c) amniotic fluid PRL may pass into the fetal tracheo-bronchial system to promote surfactant production. " 12/01/1992 - "That oligo-polyhydramnios is possibly prostaglandin mediated is suggested by the control of polyhydramnios by indomethacin treatment. "
3.	Vitamin DFDA LinkGeneric 07/01/2015 - "Taking vitamin D supplements, compared with placebo, resulted in improved pregnancy outcomes; such that those in the vitamin D group had no case of polyhydramnios, while 17.4% of subjects in placebo group had this condition (p=0.04). " 01/01/2019 - "For secondary outcomes, our results suggest that vitamin D supplementation in pregnant women with GDM may reduce newborn complications such as hyperbilirubinemia, polyhydramnios (RR: 0.40, 95% CI: 0.23 to 0.68; RR: 0.17, 95% CI: 0.03 to 0.89; respectively), and the need for maternal or infant hospitalization (RR: 0.13; 95% CI: 0.02 to 0.98; RR: 0.40, 95% CI: 0.23 to 0.69). " 07/01/2015 - "In conclusion, vitamin D supplementation for 6 weeks among pregnant women with GDM resulted in decreased maternal polyhydramnios and infant hyperbilirubinemia compared with placebo. " 01/01/2016 - "Risk of abortion was 3.1(1.39-6.8) and higher in severely deficient group in comparison to women with vitamin D deficiency (p=0.017) and mean of vitamin D group was significantly lower in women who had oligohydramnios or polyhydramnios complication (p=0.045). "
4.	Ethanol (Ethyl Alcohol)IBA 02/01/2004 - "Rapid growth of the acardiac sibling, high diastolic velocity Doppler waveforms in the perfusing vessel, and early hydramnios prompted ablation of blood flow by a percutaneous ultrasonographically guided infusion of absolute alcohol. " 01/01/2007 - "Successful intratumoral injection of absolute ethyl alcohol relieved hydrops fetalis and polyhydramnios. "
5.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2006 - "Exclusion criteria were: previous preterm delivery, or mid-trimester abortion or termination of pregnancy, multiple gestation, oligo- or polyhydramnios, placenta previa, fetal abnormalities, uterine malformations, cervical incompetence, cervical cerclage, or receipt of an antibiotic effective against BV or GBS following the screening. "
6.	Glucose (Dextrose)FDA LinkGeneric 01/01/2018 - " This study aims to investigate the perinatal outcome of fetuses with polyhydramnios and/or accelerated growth among women with a normal oral glucose challenge test (oGCT). " 03/01/2023 - "This retrospective cohort study assessed obstetrical and neonatal outcomes of 238 women with normal (24-28 week) glucose screening results, who underwent late repeat oral glucose tolerance tests (OGTT) (>34 weeks) due to a suspected LGA fetus (54.6%) or polyhydramnios (45.4%). " 12/01/2021 - "A retrospective cohort study including all women ≥37 weeks of gestation, with normal glucose challenge test (GCT), who performed 100 g OGTT at term, due to LGA fetus or polyhydramnios between January 2012 and January 2017. " 12/01/2021 - "To compare obstetric outcomes in women with and without abnormal oral glucose tolerance test (OGTT) conducted at term due to large for gestational age (LGA) fetuses or polyhydramnios. " 11/01/2017 - "No significant differences were found in risk factors for GDM, mean second trimester GCT (117.5 vs. 107.2 mg/dL, p = 0.38) or fasting glucose values (82 vs. 86 mg/dL, p = 0.29) between women in the polyhydramnios group with and without late GDM diagnosis. "
7.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 06/18/1998 - "Rarer causes of malpractice problems relate to failure to communicate the results of a sonogram in a timely fashion, failure to inform the patient of the findings about the sonogram at the time the patient is seen, and failure to perform ultrasound studies for anomalies when there is clinical indication to do so, such as elevated alpha-fetoprotein or polyhydramnios. " 08/01/2023 - "Antenatally, elevated maternal alpha-fetoprotein or polyhydramnios may be clue to diagnosis. " 01/27/2022 - "Female-to-male ratio was 2.5:1. Twenty percent of cases presented prenatally with polyhydramnios or elevated alpha-fetoprotein. " 05/01/2009 - "They have been associated with increased alpha-fetoprotein (AFP), hydramnios, congenital anomalies, and increased perinatal mortality. " 02/01/2002 - "The pregnancy was complicated by severe polyhydramnios and elevated amniotic fluid alpha-fetoprotein (AFP). "
8.	TOPSIBA 01/01/2023 - "The survival rate of the fetuses in 15 pregnancies with Twin Oligo-Polyhydramnios Sequence (TOPS) was 73.3% for one twin and 53.3% for both twins. " 09/01/2002 - "The purpose of this study was to review consecutive pregnancies complicated by twin oligohydramnios-polyhydramnios sequence (TOPS) and to clarify the probable factors influencing the perinatal outcomes. " 03/01/2012 - "Twin-to-twin transfusion syndrome (TTTS), also called twin oligoamnios polyhydramnios sequence (TOPS) complicates around 15% of monochorionic pregnancies irrespective of the mode of conception. " 06/01/2008 - "Antenatal sonographic diagnosis of twin-twin transfusion syndrome (TTTS) is based on findings of a twin oligo-polyhydramnios sequence (TOPS) observed in monochorionic twin fetuses. " 03/01/1999 - "To measure acute and chronic changes in the placenta and amniotic fluid associated with performance of decompression amniocentesis in pregnancies with the twin oligohydramnios-polyhydramnios sequence (TOPS). "
9.	Insulin (Novolin)FDA Link 10/01/2012 - "Mod-MPI was also higher in the presence of polyhydramnios (0.49 vs 0.41, P < 0.0001), insulin use (0.46 vs 0.40, P < 0.05), and large for gestational age fetuses (0.49 vs 0.40, P < 0.0001). " 08/01/2021 - "The first-line agent for GDM is insulin injections; however, it has high costs and also causes its own feto-maternal complications which can include weight gain and polyhydramnios. " 04/01/2014 - "The numbers of women who commenced insulin therapy after dietary intervention, the mode of delivery and prevalence of polyhydramnios were assessed. " 12/01/2022 - "Secondary outcomes were the rate of insulin treatment and the perinatal outcome consisting of birthweight, large-for-gestational-age, and polyhydramnios. " 03/01/2017 - "Neonatal hypoglycemia and polyhydramnios remain greater among women with insulin-treated GDM."
10.	Hemoglobins (Hemoglobin)IBA 09/01/2010 - "Women with polyhydramnios had increased hemoglobin A1c (HbA1c) levels throughout the pregnancy, and the difference was significant during the prepregnancy period and in the third trimester (P = 0.003 and P = 0.025, respectively). " 04/01/2016 - "Small intertwin placental vascular communications allow transfusion, which results in a hemoglobin difference in the twins in the absence of oligohydramnios or polyhydramnios. " 03/01/2013 - "There is a typical oligohydramnios/polyhydramnios sequence in the TTTS syndrome, whereas TAPS is characterized by large inter-twin hemoglobin difference in the absence of amniotic fluid discordances. " 06/01/1997 - "In the other two cases, the hemoglobin concentration of the four fetuses with coexistent oligohydramnios-polyhydramnios was within the normal range. " 11/01/2016 - "Twin anemia-polycythemia sequence (TAPS) is characterized by a wide discrepancy of hemoglobin between two monochorionic fetuses without sign of twin oligo-polyhydramnios sequence. "

Therapies and Procedures

1.	Therapeutics 06/01/2013 - "Compared with therapy C, therapy A and therapy B may appear to be more effective for polyhydramnios. " 07/01/1989 - "Improved postnatal therapy or surgical intervention before birth will be necessary to salvage the CDH fetus with an early gestational diagnosis or associated polyhydramnios." 01/01/2021 - "Therefore, further in vitro and in vivo studies are necessary to dissect the potential of hAFSCs from polyhydramnios in stem cell-based therapies. " 12/01/2013 - "Polyhydramnios: Causes, Diagnosis and Therapy." 06/01/2013 - "Therapy B was more effective than therapy C in general clinical improvement and decrease of AFI for polyhydramnios (P<0.01). "
2.	Decompression 12/01/2021 - "Subsequent prenatal imaging demonstrated interval spontaneous decompression of the stomach without the development of polyhydramnios, obscuring the diagnosis. " 09/01/1992 - "Amniotic fluid decompression was performed for symptomatic polyhydramnios complicating four sets of discordant twin gestations. " 09/01/1992 - "Reduction in the middle cerebral artery pulsatility index after decompression of polyhydramnios in twin gestation." 01/01/1988 - "Reversal of acute polyhydramnios after fetal renal decompression." 03/01/1999 - "Equalization of amniotic fluid volumes after decompression amniocentesis for treatment of the twin oligohydramnios-polyhydramnios sequence."
3.	Renal Dialysis (Hemodialysis) 07/01/2002 - "Polyhydramnios occurred in 6 of 9 surviving live births and was partially relieved after hemodialysis. " 09/01/1988 - "Polyhydramnios appears to be a major complication in women dependent upon chronic hemodialysis." 09/01/2018 - "Our results showed that a good fetal outcome could be reached and that preeclampsia, lupus, primigravida, residual diuresis, polyhydramnios, and hemodialysis dose were important variables associated with this outcome. " 01/01/2023 - "Against the background of hemodialysis, pregnancy, accompanied by polyhydramnios, anemia, and secondary arterial hypertension, occurred in 2021. " 07/01/1990 - "We report a case of successfully managed pregnancy complicated by maternal chronic renal failure requiring hemodialysis, severe intrauterine growth retardation and polyhydramnios. "
4.	Cervical Cerclage 01/01/2010 - "The rate of cesarean section and cervical cerclage was significantly higher in the group I. Polyhydramnios occurred less frequently in group I than in group III. The discordant growth of fetuses occurred significantly more frequently in the group I. The frequency of other complications did not differ in the studied groups. " 07/01/2021 - "Threatened preterm labor, maternal tocolysis, multiple gestations, polyhydramnios, ruptured fetal membranes, fetal complications, history of cervical conization, and the presence of cervical cerclage were the exclusion criteria. " 01/01/2006 - "Exclusion criteria were: previous preterm delivery, or mid-trimester abortion or termination of pregnancy, multiple gestation, oligo- or polyhydramnios, placenta previa, fetal abnormalities, uterine malformations, cervical incompetence, cervical cerclage, or receipt of an antibiotic effective against BV or GBS following the screening. "
5.	Cesarean Section (Caesarean Section) 01/20/2023 - "A 36-year-old multipara underwent an emergent cesarean section because of polyhydramnios and active labor at 35 + 5 weeks of gestation and gave birth to a girl. " 01/22/2021 - "A statically significant association was found between polyhydramnios and late term deliveries (P = 0.005) and cesarean section (CS) rates (P = 0.008). " 10/01/2020 - "Relative to the pregnancies without diabetes, women with T1DM encountered increasing risk of polyhydramnios, preterm delivery, and cesarean section. " 02/01/2018 - "Women with GDM-I had a greater risk of polyhydramnios (aOR 2.33, 95%CI 1.31-4.14) and were more likely to deliver by caesarean section (CS) (aOR 1.67, 95%CI 1.25-2.23). " 08/01/2017 - "One patient delivered her baby at a gestational age at 32 weeks due to idiopathic polyhydramnios by cesarean section. "