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Hyaluronoglucosaminidase (Hyaluronidase)

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An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.

Also Known As:

Hyaluronidase; Wydase; Duran-Reynals Permeability Factor; GL Enzyme; Hyaglosidase; Hyaluronate Hydrolase; Duran Reynals Permeability Factor; Factor, Duran-Reynals Permeability; Hydrolase, Hyaluronate; Permeability Factor, Duran-Reynals; Hyaluronate 4-glycanohydrolase

Networked: 1417 relevant articles (50 outcomes, 137 trials/studies)

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Drug Context: Research Results

Experts

1.	Lokeshwar, Vinata B: 16 articles (01/2014 - 07/2002)
2.	Simpson, Melanie A: 8 articles (05/2015 - 07/2006)
3.	Girish, K S: 8 articles (07/2014 - 01/2002)
4.	Soloway, Mark S: 8 articles (01/2010 - 07/2002)
5.	Stern, Robert: 8 articles (07/2008 - 01/2002)
6.	Dygai, A M: 7 articles (02/2014 - 10/2010)
7.	Madonov, P G: 7 articles (02/2014 - 10/2010)
8.	Kemparaju, K: 7 articles (01/2013 - 01/2002)
9.	Frost, Gregory I: 6 articles (02/2015 - 11/2002)
10.	Eissa, Sanaa: 6 articles (04/2014 - 04/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2008 - "Antitumor activity and overall survival of mice bearing highly aggressive tumors are significantly improved by codelivery of oncolytic adenoviruses and hyaluronidase when compared with either of the monotherapy-treated groups, and it may prove to be a potent and novel approach to treating patients with cancer." 08/01/1996 - "The application of hyaluronidase was associated with a statistically significant improvement in the tumor (maximum)-to-blood concentration ratio of 1.83 (range, 0.68-3.67) compared with 1.31 (range, 0.8-1.78) with BSH alone. " 12/01/2003 - "Treatment of tumor cell--pre-exposed monocytes with hyaluronidase (HAase) improved their depressed production of TNF, while HAase-treated cancer cells did not cause monocyte dysfunction. " 11/01/2000 - "This model may help to understand tumor spread on HA tissue structures and may explain therapy successes with hyaluronidase in tumor patients." 02/15/2008 - "The purpose of this study is to investigate whether expression of hyaluronoglucosaminidase 1 (HYAL1), a known tumor promoter, in hyperplastic tissues identifies a "true precancerous stage" and predicts subsequent IBC development. "
2.	Edema 01/01/2010 - "Reduction of edema by hyaluronidase and facilitation of epidural adhesioloysis may be beneficial in treating certain chronic painful conditions." 01/01/2014 - "The purpose of this study was to validate the efficacy of hyaluronidase in the management of lower eyelid edema. " 01/01/1999 - "Hyaluronidase ameliorates rejection-induced edema." 01/01/1996 - "In hearts preserved with hyaluronidase-containing solutions, the edema formation during reperfusion was reduced combined with an improvement in the coronary flow. " 03/01/1997 - "[Experimental study on myocardial edema and cardiac lymph in the preserved heart--effect of hyaluronidase]."
3.	Wounds and Injuries (Trauma) 01/01/2015 - "A number of studies, for example, suggest that both the removal of high molecular weight HA and the accumulation of hyaluronidase-generated HA digestion products can impact CNS injuries through mechanisms that include the regulation of progenitor cell differentiation and proliferation. " 01/01/2012 - "Randomised controlled trials (RCT) and quasi-randomised controlled trials comparing saline irrigation with or without hyaluronidase infiltration with no intervention or normal wound care in the management of extravasation injury in neonates. " 01/01/2001 - "Hyaluronidase modification becomes an informative tool to study the mechanism of inhibition of its enzyme activity and an efficient means for the development of new therapeutic preparations improving tissue permeability during cardiovascular injuries." 01/01/1997 - "The present study determined the levels and size of HA, as well as hyaluronidase levels, in fetal and adult lamb wounds. " 06/01/1986 - "This study establishes the existence of a mammalian buccal mucosal wound hyaluronidase (hyaluronate 4-glycohydrolase; EC 3.2.1.35) having properties distinct from those of the endogenous lysosomal hyaluronidase of normal (uninjured) buccal mucosa. "
4.	Pain (Aches) 11/01/2010 - "The addition of hyaluronidase to fluoroscopically guided caudal epidural steroid and hypertonic saline combination improved long-term pain relief in patients with FBSS." 01/01/2015 - "Pain Levels after Local Anaesthetic with or without Hyaluronidase in Carpal Tunnel Release: A Randomised Controlled Trial." 05/01/1994 - "An increase in the number of patients who reported complete absence of pain was recorded when hyaluronidase was added to the study medications. " 02/01/2015 - "The rebound pain (the re-occurrence of pain within 2-4 weeks after injection) that occurs within 2-4 weeks after the injection of the routine regimen can be reduced when hyaluronidase is added to the routine SNRB regimen." 01/01/2015 - "Hyaluronidase addition to local anaesthetic in carpal tunnel release resulted in significant reductions in operative time and pain immediately after operation. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 02/01/2010 - "We assessed the diagnostic efficacy of hyaluronidase (HYAL1) and survivin for early bladder cancer detection. " 09/01/1999 - "In this study, we characterized the bladder tumor-derived hyaluronidase. " 04/15/2014 - "Hyaluronidase (HAase) was reported as a urinary marker of bladder cancer. " 04/01/2012 - "Combined use of RAR-β2 gene promoter methylation, hyaluronidase activity and VUC is promising non-invasive tool for bladder cancer detection." 01/01/2010 - "HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Lidocaine (Xylocaine)
3.	Triamcinolone (Aristocort)
4.	Messenger RNA (mRNA)
5.	Vinblastine (Vinblastine Sulfate)
6.	Pancreatic Elastase (Elastase)
7.	Mitomycin (Mitomycin-C)
8.	Dexamethasone (Maxidex)
9.	Epinephrine (Adrenaline)
10.	Propranolol (Inderal)

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Local Anesthesia
4.	Intralesional Injections
5.	Ligation