Hyaluronoglucosaminidase (Hyaluronidase)

An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.

Also Known As:

Hyaluronidase; Wydase; Duran-Reynals Permeability Factor; GL Enzyme; Hyaglosidase; Hyaluronate Hydrolase; Duran Reynals Permeability Factor; Factor, Duran-Reynals Permeability; Hydrolase, Hyaluronate; Permeability Factor, Duran-Reynals; Hyaluronate 4-glycanohydrolase

Networked: 2052 relevant articles (118 outcomes, 215 trials/studies)

Relationship Network

Drug Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Hyaluronoglucosaminidase: 2052
        lidase: 45
        PEGPH20: 41
        Longidaza: 13
        Hyaluronidase Deficiency: 3
        allergen Ves v 1
        allergen Ves v 2
        Apis mellifera Api m 2 allergen
        Buthus martensi BmHYA1 protein
        human CEMIP protein
        human HYAL1 protein
        human Hyal2 protein
        human OGA protein
        hyaluronidase PH-20
        mouse Cemip protein
        mouse Hyal1 protein
        mouse Hyal2 protein
        mouse Hyal5 protein
        mouse Hyalp1 protein
        Xenopus Hyal2 protein
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Polysaccharide-Lyases: 2
        Hyaluronoglucosaminidase: 2052
        lidase: 45
        PEGPH20: 41
        Longidaza: 13
        Hyaluronidase Deficiency: 3
        allergen Ves v 1
        allergen Ves v 2
        Apis mellifera Api m 2 allergen
        Buthus martensi BmHYA1 protein
        human CEMIP protein
        human HYAL1 protein
        human Hyal2 protein
        human OGA protein
        hyaluronidase PH-20
        mouse Cemip protein
        mouse Hyal1 protein
        mouse Hyal2 protein
        mouse Hyal5 protein
        mouse Hyalp1 protein
        Xenopus Hyal2 protein

Experts

1.	Lokeshwar, Vinata B: 18 articles (11/2017 - 07/2002)
2.	Simpson, Melanie A: 9 articles (01/2019 - 07/2006)
3.	Soloway, Mark S: 9 articles (11/2017 - 07/2002)
4.	Girish, K S: 9 articles (07/2014 - 01/2002)
5.	Alemany, Ramon: 8 articles (01/2022 - 07/2010)
6.	Shepard, H Michael: 8 articles (11/2019 - 09/2012)
7.	Kemparaju, K: 8 articles (01/2013 - 01/2002)
8.	Stern, Robert: 8 articles (07/2008 - 01/2002)
9.	Dygai, A M: 7 articles (02/2014 - 10/2010)
10.	Madonov, P G: 7 articles (02/2014 - 10/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2008 - "Antitumor activity and overall survival of mice bearing highly aggressive tumors are significantly improved by codelivery of oncolytic adenoviruses and hyaluronidase when compared with either of the monotherapy-treated groups, and it may prove to be a potent and novel approach to treating patients with cancer." 08/01/1996 - "The application of hyaluronidase was associated with a statistically significant improvement in the tumor (maximum)-to-blood concentration ratio of 1.83 (range, 0.68-3.67) compared with 1.31 (range, 0.8-1.78) with BSH alone. " 01/01/2020 - "The HA shell protection can be eliminated in position at the tumor to trigger O2 release through hyaluronidase (HAase) triggered HA degradation. " 01/01/2017 - "Antibody staining was found both within cancer cells and in the extracellular matrix and staining could not be eliminated by hyaluronidase predigestion of the tissue sections. " 01/01/2016 - "VCN-01 is a replication-competent adenovirus specifically engineered to replicate in tumors with a defective RB pathway, presents an enhanced infectivity through a modified fiber and an improved distribution through the expression of a soluble hyaluronidase. "
2.	Oral Submucous Fibrosis 04/01/2020 - "Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta-analysis of randomized controlled clinical trials." 10/01/2022 - "Objectives are to determine compare the efficacy of intralesional steroids alone and combination of steroids with hyaluronidase on mouth opening in oral submucous fibrosis. " 10/01/2022 - "Comparison Of Efficacy Of Steroids Alone And Combination Of Steroids With Hyaluronidase On Mouth Opening In Oral Submucous Fibrosis Patients." 10/01/2020 - "To assess the efficacy of betamethasone, hyaluronidase and its combination on mouth opening, burning sensation and quality of life (QOL) in patients with oral submucous fibrosis. " 04/01/2020 - "This meta-analysis was performed to systematically evaluate the efficacy of hyaluronidase combined with corticosteroids compared with other drugs in improving maximum mouth opening and alleviating the burning sensation in patients with oral submucous fibrosis (OSF). "
3.	Pain (Aches) 07/01/2019 - "The skin color improved with decreased pain, and the next day (after 14 hours) we injected 500 units of hyaluronidase in higher dilution of 10mL as slight redness was still present. " 11/01/2019 - "One randomized trial specifically looking at the use of hyaluronidase in neuroplasty found that the addition of hyaluronidase improved pain ratings at 12 months compared to other techniques and decreased the number of procedures needed to gain effect. " 01/01/2018 - "We included seven trials involving 500 participants that studied the effect of hyaluronidase on intraoperative pain. " 01/01/2018 - "We included randomized controlled trials (RCTs) that evaluated the effect of hyaluronidase on pain experienced by adults during intraocular surgery using a rating scale. " 01/01/2015 - "Pain Levels after Local Anaesthetic with or without Hyaluronidase in Carpal Tunnel Release: A Randomised Controlled Trial."
4.	Necrosis 01/01/2022 - "After hyaluronidase injection, facial skin necrosis in all cases was restored and ptosis in the 4 cases was also significantly relieved. " 10/01/2020 - "Dose, timing, and efficacy of hyaluronidase use in skin necrosis are discussed. " 04/21/1977 - "Thus, hyaluronidase reduced the frequency of electrocardiographic signs of myocardial necrosis." 01/01/2020 - "This study aimed to determine the effective dose and administration interval of hyaluronidase injection in a skin necrosis animal model. " 07/01/1993 - "In study I, hyaluronidase treated groups had significantly fewer and smaller areas of necrosis than other groups. "
5.	Edema (Dropsy) 01/01/2010 - "Reduction of edema by hyaluronidase and facilitation of epidural adhesioloysis may be beneficial in treating certain chronic painful conditions." 04/30/2021 - "The anti-edema effect of hyaluronidase was more effective in the maxilla than in the mandible. " 01/01/2020 - "Single treatment was effective in 92% of patients with 8% requiring another hyaluronidase injection to completely eradicate residual edema. " 05/28/2014 - "The purpose of this study was to validate the efficacy of hyaluronidase in the management of lower eyelid edema. " 04/01/2020 - "Every patient improved after an injection of hyaluronidase, even after experiencing many years of persistent edema. "

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Steroids
3.	Dexamethasone (Maxidex)
4.	Triamcinolone (Aristocort)
5.	PEGPH20
6.	Curcumin
7.	Triamcinolone Acetonide (Azmacort)
8.	Lidocaine (Xylocaine)
9.	Mitomycin (Mitomycin-C)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Intralesional Injections
5.	Local Anesthesia