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Deltaretrovirus Infections (BLV Infection)

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Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).

Also Known As:

BLV Infection; Deltaretrovirus Infection; HTLV BLV Infections; HTLV Infection; HTLV-BLV Infection; Infection, Deltaretrovirus; Infections, Deltaretrovirus; BLV Infections; HTLV Infections; HTLV-BLV Infections

Networked: 158 relevant articles (3 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymphocytosis
2.	Infection
3.	T-Cell Lymphoma (Lymphoma, T Cell)
4.	T-Cell Leukemia (Leukemia, T Cell)
5.	Neoplasms (Cancer)

Experts

1.	Konnai, Satoru: 8 articles (02/2015 - 11/2003)
2.	Ohashi, Kazuhiko: 7 articles (02/2015 - 11/2003)
3.	Onuma, Misao: 7 articles (01/2012 - 11/2003)
4.	Kohara, Junko: 4 articles (02/2015 - 09/2005)
5.	Usui, Tatsufumi: 4 articles (01/2007 - 11/2003)
6.	Murata, Shiro: 3 articles (02/2015 - 01/2011)
7.	Ikebuchi, Ryoyo: 3 articles (02/2015 - 01/2011)
8.	Manel, Nicolas: 3 articles (08/2005 - 11/2003)
9.	Sitbon, Marc: 3 articles (08/2005 - 11/2003)
10.	Battini, Jean-Luc: 3 articles (08/2005 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Deltaretrovirus Infections:

1.	DNA (Deoxyribonucleic Acid)IBA 11/01/2003 - "Protective effects of vaccination with bovine leukemia virus (BLV) Tax DNA against BLV infection in sheep." 05/01/2006 - "Our experiments demonstrated that rectal palpation is a potential cause of BLV spread in herds and that detection of BLV proviral DNA in cattle by PCR is useful screening test for early diagnosis of BLV infection." 06/15/2005 - "With the aim of achieve a better understanding of the epidemiology and distribution of bovine leukaemia virus (BLV) infection in Chile, we assessed the suitability of using DNA isolated from the leukocyte fraction of bulk milk samples to carry out PCR-RFLP and DNA sequence analysis. " 01/01/1999 - "Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination." 11/01/1996 - "We compare the use of not purificated with highly-purified DNA in the PCR-based diagnosis of BLV infection. "
2.	A-Form DNA (A-DNA)IBA 11/01/2003 - "A DNA vaccination trial was performed on sheep to determine whether vaccination with bovine leukemia virus (BLV) transactivator Tax DNA is effective against BLV infection. "
3.	Trans-Activators (Trans-Acting Factor)IBA 11/01/2003 - "A DNA vaccination trial was performed on sheep to determine whether vaccination with bovine leukemia virus (BLV) transactivator Tax DNA is effective against BLV infection. "
4.	N-acetyltalosaminuronic acid (NAT)IBA 05/01/2015 - "Donors with serologic and nucleic acid testing (NAT) or NAT-only confirmed human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), or serology-confirmed human T-lymphotropic virus (HTLV) infections (cases) and donors with false-positive results (controls) were interviewed for putative behavioral and demographic risks. "
5.	hydroquinone (Black and White)FDA Link 01/01/1993 - "Effective protection against BLV infection was induced by the tested immunogen in all Brown Latvian calves for 6 months and in 70% of the Black and White calves."
6.	AntibodiesIBA 01/01/2014 - "Further studies on the sensitivity, specificity, and reliability of assays using antibodies to HTLV-1 and 2 in breast milk will be necessary for large-scale epidemiological surveys of HTLV infection. " 09/01/1997 - "All of the patients in whom HTLV-I/HTLV-II discrimination was successful had HTLV-II, with the exception of one patient who was infected by HTLV-I. The present study confirms the possibility of HTLV infection in the absence of ELISA-detectable serum anti-HTLV-I/II antibodies, especially in the particular setting of HIV-1-infected individuals. " 04/01/1983 - "These studies are consistent with previous evidence indicative of a high rate of HTLV infection within families, and they show that people whose sera are negative for antibodies may still be infected by HTLV. " 04/01/2015 - "To estimate the rate of BLV infection, a survey for specific antibodies in 28,982 serum samples from animals belonging to 1116 different herds situated in Central Anatolia Region of Turkey were tested from January 2006 to December 2013. " 04/15/2014 - "Veterinarians should be aware of recent developments for screening serum and milk samples for antibodies against BLV and the results of research regarding the economic impact of BLV so they can advise their dairy clients of available alternatives for monitoring and controlling BLV infection."
7.	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 12/01/2007 - "The present study investigated the frequency of the mutations at positions -550 and -221 of the mannose-binding lectin (MBL) gene in a sample of 75 human T-cell lymphotropic virus (HTLV) infected patients and 96 HTLV seronegative controls, in order to evaluate the occurrence of a possible association between the polymorphism and HTLV infection. " 08/01/2005 - "The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and the susceptibility to human T-cell lymphotropic virus (HTLV) infection in a group of 83 HTLV-infected asymptomatic subjects (62 HTLV-1 and 21 HTLV-2) and 99 healthy controls. "
8.	AgarIBA 02/24/2011 - "A seroepidemiological survey of bovine leukemia virus (BLV) infection was conducted in Japan in 2007 using an enzyme-linked immunosorbent assay (ELISA) and an agar gel immunodiffusion (AGID) test. " 10/01/1999 - "An indirect enzyme-linked immunosorbent assay (ELISA) for the diagnosis of bovine leukaemia virus (BLV) infection was developed and compared with the agar gel immunodiffusion test (AGIDT). " 04/01/1994 - "Initial testing of the infected herd using a single amplification PCR (SA-PCR), detected BLV infection in 62 of 72 adult animals that were seropositive by the agar gel immunodiffusion (AGID) test and in one persistently seronegative cow. " 04/01/1990 - "The sensitivity and specificity of the p24-ELISA for diagnosing BLV infection relative to the gp51 agar gel immunodiffusion test, were 98.1 and 96.7%, respectively. " 10/01/1989 - "The ELISA was more sensitive and more reliable than the agar gel immunodiffusion (AGID) test in detecting BLV infection in cattle persistently infected with BVDV. "
9.	Messenger RNA (mRNA)IBA 02/15/2015 - "The percentage of CTLA-4(+) cells in the CD4(+) T cell subpopulation was positively correlated with TGF-β mRNA expression, suggesting that CD4(+)CTLA-4(+) T cells have a potentially immunosuppressive function in BLV infection. " 01/01/2012 - "Tim-3 mRNA expression in CD4+ and CD8+ cells was upregulated during disease progression of BLV infection. " 07/01/2000 - "Competitive RT-PCR analysis of IFN-gamma mRNA expression revealed that peripheral blood mononuclear cells (PBMC) of animals with PL+ status developed by 4 weeks after infection had augmented IFN-gamma mRNA expression 3-4 weeks after BLV infection. " 01/15/2007 - "The virus did not propagate well in three sheep, which showed augmented mRNA expression of IFN-gamma, a strong indicator of cell-mediated immunity, immediately after BLV-infection. " 08/30/2001 - "To examine whether tumor necrosis factor alpha (TNF alpha) contributes to the pathogenesis of bovine leukemia virus (BLV) infection, the mRNA expression patterns of TNF alpha and its receptors, type 1 (TNF R1) and type 2 (TNF R2) were investigated. "
10.	Telomerase (Telomerase Reverse Transcriptase)IBA 06/01/2015 - "Interaction between Bovine leukemia virus (BLV) infection and age on telomerase misregulation." 02/05/2008 - "Therefore, we investigated telomerase activity in bovine leukaemia, the most common tumour in cows and its relationship with the bovine leukaemia virus (BLV) infection, which is the major cause of leukaemia. " 06/01/2015 - "This study demonstrates that there is a significant interaction between BLV infection and telomerase up-regulation and lymphocytosis." 06/01/2015 - "Older animals with BLV infection, especially those with persistent lymphocytosis or visible tumors, exhibited a sharp increase in telomerase activity. "

Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions) 01/01/2014 - "A prevalence of 5.1% of HTLV among patients with lymphoid malignancies was found in this study, and previous history of blood transfusion was not found to be a significant cause of HTLV infection." 09/01/1998 - "HTLV infection diagnostic implements are detailed: screening and specially confirmatory tests are brought to light with the help of concrete examples interpreted according to the criteria defined by the Retrovirus Study Group of the French Blood Transfusion Society." 04/01/1994 - " HTLV infections, like HIV, are transmitted sexually, via blood transfusion and contaminated needles, and from mother to infant. " 05/01/2002 - "A high frequency of past blood transfusion (32.6%) suggests that blood-borne infection was an important means of HTLV infection before implementation of screening of blood donors in Brazil."
2.	Injections 11/01/1981 - "Neither BLV infection nor lymphosarcoma was observed in control uninoculated sheep or in sheep given injections of PHA-treated cultures of lymphocytes from BLV-free cows. " 04/01/2000 - "Our results demonstrate that vaccines based on live attenuated viruses and naked DNA injections are able to delay BLV infection, although complete protection cannot be achieved. "
3.	Donor Selection 04/01/2001 - "Six Afro-Caribbean donors (0.55%) were considered to be infected with HTLV I. Donor selection in this case caused a significantly elevated prevalence of HTLV infection and serves as a warning of the need for care in the design of policies for selective donor recruitment."
4.	Transplants (Transplant) 12/01/2005 - "[HTLV infection after renal transplant]."
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/01/1987 - "[HTLV infection in patients with bone marrow transplantation]."