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Homovanillic Acid

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Also Known As:

3-Methoxy-4-Hydroxyphenylacetic Acid; 4-Hydroxy-3-Methoxyphenylacetic Acid; 3 Methoxy 4 Hydroxyphenylacetic Acid; 4 Hydroxy 3 Methoxyphenylacetic Acid; Acid, 3-Methoxy-4-Hydroxyphenylacetic; Acid, 4-Hydroxy-3-Methoxyphenylacetic; Acid, Homovanillic; Benzeneacetic acid, 4-hydroxy-3-methoxy-

Networked: 686 relevant articles (10 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Phenylacetates
      - Homovanillic Acid: 686
        vanillactic acid: 7
        m-hydroxyphenylacetic acid: 1
        vanilglycolic acid: 1
        4-hydroxyphenylacetic aciduria
        6-fluorohomovanillic acid
        homovanillic alcohol
        isohomovanillic acid

Experts

1.	Nakamura, Jun: 8 articles (01/2015 - 03/2003)
2.	Yoshimura, Reiji: 8 articles (01/2015 - 03/2003)
3.	Hori, Hikaru: 6 articles (01/2015 - 12/2009)
4.	Niwa, Shin-Ichi: 5 articles (12/2015 - 09/2012)
5.	Mashiko, Hirobumi: 5 articles (12/2015 - 09/2012)
6.	Miura, Itaru: 5 articles (12/2015 - 09/2012)
7.	Katsuki, Asuka: 5 articles (01/2015 - 03/2012)
8.	Umene-Nakano, Wakako: 5 articles (04/2014 - 12/2009)
9.	Kanno-Nozaki, Keiko: 4 articles (12/2015 - 01/2014)
10.	Yabe, Hirooki: 4 articles (12/2015 - 01/2014)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 03/01/1995 - "Cerebrospinal fluid homovanillic acid in the DATATOP study on Parkinson's disease. " 07/01/1993 - "We studied visual (VEP) and brainstem auditory (BAEP) evoked potential changes in 23 patients with early onset Parkinson's disease (EOPD) to establish the nature of the changes as well as their relationship to dopaminergic (DA) and serotonergic (5-HT) disturbances, as determined by cerebrospinal fluid levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). " 09/01/1985 - "The concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were determined in the cerebrospinal fluid in 17 patients with Parkinson's disease and 10 controls. " 10/01/1983 - "Cerebrospinal fluid levels of homovanillic acid (HVA) in unmedicated patients with Parkinson's disease were 45% of levels in control subjects. " 03/01/1973 - "[Determination of homovanillic acid in the cerebrospinal fluid of Parkinson's disease patients and control group]."
2.	Atrophy 02/01/1986 - "The clinical examination revealed generalized slowing in EEG, mixed sensory and motor neuropathy in EMG, thick skull, both cerebral cortical atrophy and ventricular dilatation in computed tomography and marked decrease in cerebrospinal homovanillic acid content. " 12/01/1987 - "The schizophrenic patients, however, differed from both control groups in terms of greater prefrontal cortical markings consistent with prefrontal atrophy, and this finding correlated inversely with levels of cerebrospinal fluid homovanillic acid. " 04/01/1994 - "Other important findings were decreased levels of 5-hydroxy-indoleacetic acid (5-HILA) and homovanillic acid (HVA) in the CSF, cerebellar and basal ganglia atrophy seen in MRI and infertility of probable gonadal origin." 07/01/1988 - "Patients who responded favorably to alprazolam treatment were significantly more psychotic or anxious before treatment, were older, showed significant alprazolam-associated reductions in plasma levels of homovanillic acid, and had significantly more prominent prefrontal cortex atrophy on computed tomographic scans than patients in whom alprazolam was without therapeutic effect. " 10/01/1986 - "Patients with cortical atrophy had lower cerebrospinal fluid levels of homovanillic acid, DOPAC, and conjugated DOPAC but higher DASO4 levels. "
3.	Schizophrenia (Dementia Praecox) 10/01/1991 - "Plasma homovanillic acid concentrations have been reported to decrease during neuroleptic treatment, with the decrement correlating with symptomatic improvement in symptoms of schizophrenia. " 01/01/1994 - "Both (1) platelet and neuroendocrine markers of serotonergic function and (2) an individual's capacity to decrease plasma homovanillic acid concentrations following neuroleptic blockade appear to be less state dependent, and these are worthy of further study as markers of risk for the development of schizophrenia." 07/01/1979 - "Pathophysiological studies on schizophrenia with special reference to homovanillic acid concentration in cerebrospin fluid." 08/01/2011 - "Variability of plasma homovanillic acid over 13 months in patients with schizophrenia; relationship with the clinical response and the Wisconsin card sort test." 09/01/2006 - "Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia. "
4.	Parkinsonian Disorders (Parkinsonism) 01/01/1994 - "Homovanillic acid content was found to be significantly lower in patients with severe parkinsonism (motor score of UPDRS > 24), but not in patients with mild symptoms (motor score < or = 24). " 08/01/1986 - "In addition the patient had Parkinsonism and reduced concentrations of homovanillic acid, 5-hydroxyindoleacetic acid and total biopterins in cerebrospinal fluid. " 07/01/1981 - "A profound decrease was demonstrated in the concentration of homovanillic acid (HVA)--the end metabolite of DA in parkinsonism, reflecting damage to DA--containing pathways and reduced DA synthesis in basal ganglia. " 07/01/1974 - "Cerebrospinal homovanillic acid and parkinsonism." 04/26/1968 - "[Excretion of 3-metoxy 4-hydroxyphenylacetic (homovanillic) acid in patients with parkinsonism]."
5.	Anorexia Nervosa 02/01/2008 - "Dopaminergic abnormalities have been described in anorexia nervosa but studies about plasma level of homovanillic acid (pHVA) have yielded conflicting results probably due to the small number and the heterogeneity of patients. " 02/01/2008 - "Psychopathological and nutritional correlates of plasma homovanillic acid in adolescents with anorexia nervosa." 12/01/1979 - "Because of possible abnormalities in catecholamine metabolism, plasma levels of norepinephrine and urinary excretion of homovanillic acid and 3-methoxy-4-hydroxyphenyl glycol were studied in female patients with primary anorexia nervosa before and after significant clinical improvement and compared with normal female volunteers. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Norepinephrine (Noradrenaline)
3.	3,4-Dihydroxyphenylacetic Acid
4.	Levodopa (L Dopa)
5.	Serotonin (5 Hydroxytryptamine)
6.	Methoxyhydroxyphenylglycol
7.	Carbidopa (Lodosyn)
8.	Alprazolam (Xanax)
9.	Epinephrine (Adrenaline)
10.	gamma-Aminobutyric Acid (GABA)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Oral Administration
4.	Chemoprevention
5.	Transplantation (Transplant Recipients)