HLA-DP Antigens (HLA-DP)

A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.

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Networked: 231 relevant articles (7 outcomes, 26 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Fontenot, Andrew P: 8 articles (06/2014 - 04/2005)
2.	Amicosante, Massimo: 7 articles (09/2009 - 03/2004)
3.	Saltini, C: 6 articles (05/2004 - 03/2001)
4.	Falta, Michael T: 5 articles (06/2014 - 11/2005)
5.	Amicosante, M: 5 articles (05/2004 - 07/2001)
6.	Seto, Wai-Kay: 4 articles (03/2014 - 01/2013)
7.	Yuen, Man-Fung: 4 articles (03/2014 - 01/2013)
8.	Tanaka, Yasuhito: 4 articles (01/2014 - 01/2012)
9.	Taylor, Malcolm: 4 articles (01/2013 - 01/2008)
10.	Nakamura, Yusuke: 4 articles (10/2011 - 05/2009)

Related Diseases

1.	Infection 08/01/2012 - "Both A alleles of HLA-DP SNP rs3077 and rs9277535 showed strong protective effects for spontaneous HBV clearance from persistent HBV infection in the Han Chinese population." 01/01/2012 - "These results suggest that the associations between the HLA-DP locus and the protective effects against persistent HBV infection and with clearance of HBV were replicated widely in East Asian populations; however, there are no reports of GWAS in Caucasian or African populations. " 01/01/2013 - "We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. " 12/01/2015 - "Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection." 03/01/2015 - "In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported. "
2.	Chronic Hepatitis B 01/01/2012 - "Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean." 01/01/2014 - "Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). " 10/01/2014 - "In this large cohort of Caucasian chronic hepatitis B patients infected with HBV genotypes A or D, polymorphisms of HLA-DP are independently associated with both virological and serological response to PEG-IFN therapy at 6 months post-treatment." 10/01/2014 - "To investigate the association of HLA-DP polymorphisms with response to peginterferon (PEG-IFN) in Caucasian chronic hepatitis B (CHB) patients. " 10/01/2014 - "Polymorphisms of HLA-DP are associated with response to peginterferon in Caucasian patients with chronic hepatitis B."
3.	Hepatitis B 01/01/2013 - "Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese." 12/01/2012 - "HLA-DP gene polymorphisms and hepatitis B infection in the Japanese population." 01/01/2011 - "A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. " 09/01/2014 - "Effect of HLA-DP and IL28B gene polymorphisms on response to interferon treatment in hepatitis B e-antigen seropositive chronic hepatitis B patients." 10/01/2014 - "Many GWASs conclude that the genetic variants in the HLA region (HLA-DP, HLA-DQ, HLA-DR and MICA), KIF1B, DEPDC5 and PNPLA3 influence HBV infection, its clinical course and the response to hepatitis B vaccination. "
4.	Fibrosis (Cirrhosis) 11/01/2013 - "In conclusion, HLA-DP polymorphisms affect genotype B HBV clearance, regulate immune selection of viral mutations, and influence cirrhosis and HCC risks contributed by HBV mutations. " 11/01/2013 - "The interactions of C1653T, T1674C/G, and G1896A mutations with HLA-DP polymorphisms promoting HBV clearance significantly decreased cirrhosis risk. " 11/01/2013 - "Significant effects of viral mutations on cirrhosis and HCC were selectively evident in those with HLA-DP polymorphisms promoting HBV persistence. " 10/01/2014 - "To investigate the genetic association between cirrhosis and polymorphisms in the genes encoding major histocompatibility complex, class II (HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1). " 03/01/1999 - "HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population."
5.	Myocarditis (Carditis) 11/01/1999 - "During the last years immunohistochemical techniques have improved the diagnosis of myocarditis using specific markers for quantification of leucocytes and characterization of T-lymphocytes together with the definition of MHC class II Antigens (HLA-DP, DQ, DR), known to be enhanced in cases of myocarditis. " 11/01/1999 - "The subsequent definition of the major histocompatibility complex class II antigens (HLA-DP,DQ,DR and HLA-DR), known to be enhanced in cases of myocarditis, the quantification of leucocytes with leucocyte common antigen (LCA) and characterization and quantification of T-lymphocytes using a specific marker (CD-3) allowed the definite diagnosis of myocarditis in three additional cases, six cases were found with moderate changes and ten cases without signs of inflammation." 08/01/1991 - "There was an expression of class II antigens (HLA-DR, HLA-DP, HLA-DQ) in acute rejection and in myocarditis and in some patients with dilated cardiomyopathy on endothelial cells, interstitial cells but not on the myocytes. "

Related Drugs and Biologics

1.	Antigens
2.	HLA-DR Antigens (HLA-DR)
3.	HLA-DQ Antigens (HLA-DQ)
4.	Histocompatibility Antigens Class II
5.	HLA-DPB1 (HLA DPB1)
6.	Hepatitis B Surface Antigens (HBsAg)
7.	HLA-DPA1 (HLA DPA1)
8.	HLA-C Antigens (HLA-C)
9.	lipoarabinomannan (LAM)
10.	HLA-D Antigens

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
3.	Transplantation (Transplant Recipients)
4.	Stem Cell Transplantation
5.	Hematopoietic Stem Cell Transplantation