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HLA-D Antigens

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Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

Also Known As:

HLA-D; HLA-Dw; Immune Response Associated Antigens, Human; Antigens, HLA D; Antigens, HLA-Dw; Antigens, Human Ia-Like; Antigens, Human Immune-Associated; Antigens, Human Immune-Response; HLA D Antigens; HLA Dw Antigens; Human Ia-Like Antigens; Human Immune-Associated Antigens; Human Immune-Response Antigens; Ia Like Antigens, Human; Immune Associated Antigens, Human; Immune Response Antigens, Human; Antigens, HLA-D; Class II Human Antigens; HLA-Dw Antigens; Human Class II Antigens; Ia-Like Antigens, Human; Immune Response-Associated Antigens, Human; Immune-Associated Antigens, Human; Immune-Response Antigens, Human

Networked: 214 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 1315
- Antigens: 114404
  - Surface Antigens: 4354
    - Histocompatibility Antigens: 1123
      - HLA Antigens: 2336
        HLA-D Antigens: 214
        HLA-DR Antigens: 4419
        HLA-DQ Antigens: 648
        HLA-DP Antigens: 231
        HLA-DMB: 33
        HLA-Dw4: 12
        HLA-Dw14: 3
        HLA-Dw10: 1
        HLA-Dw12: 1
        E(S)(beta) peptide
        HLA-DB3
        HLA-DN antigens
        HLA-DO antigens
        HLA-DW14.1
        HLA-Dw19
        HLA-DZ
        HLA-Te
      - Histocompatibility Antigens Class II: 1508
        HLA-D Antigens: 214
        HLA-DR Antigens: 4419
        HLA-DQ Antigens: 648
        HLA-DP Antigens: 231
        HLA-DMB: 33
        HLA-Dw4: 12
        HLA-Dw14: 3
        HLA-Dw10: 1
        HLA-Dw12: 1
        E(S)(beta) peptide
        HLA-DB3
        HLA-DN antigens
        HLA-DO antigens
        HLA-DW14.1
        HLA-Dw19
        HLA-DZ
        HLA-Te
  - Isoantigens: 1094
    - Histocompatibility Antigens: 1123
      - HLA Antigens: 2336
        HLA-D Antigens: 214
        HLA-DR Antigens: 4419
        HLA-DQ Antigens: 648
        HLA-DP Antigens: 231
        HLA-DMB: 33
        HLA-Dw4: 12
        HLA-Dw14: 3
        HLA-Dw10: 1
        HLA-Dw12: 1
        E(S)(beta) peptide
        HLA-DB3
        HLA-DN antigens
        HLA-DO antigens
        HLA-DW14.1
        HLA-Dw19
        HLA-DZ
        HLA-Te
      - Histocompatibility Antigens Class II: 1508
        HLA-D Antigens: 214
        HLA-DR Antigens: 4419
        HLA-DQ Antigens: 648
        HLA-DP Antigens: 231
        HLA-DMB: 33
        HLA-Dw4: 12
        HLA-Dw14: 3
        HLA-Dw10: 1
        HLA-Dw12: 1
        E(S)(beta) peptide
        HLA-DB3
        HLA-DN antigens
        HLA-DO antigens
        HLA-DW14.1
        HLA-Dw19
        HLA-DZ
        HLA-Te

Experts

1.	Sorrentino, Rosalinda: 1 article (11/2015)
2.	Pecoraro, Michela: 1 article (11/2015)
3.	Di Crescenzo, Vincenzo G: 1 article (11/2015)
4.	Galderisi, Antonio: 1 article (11/2015)
5.	Pinto, Aldo: 1 article (11/2015)
6.	Popolo, Ada: 1 article (11/2015)
7.	Perillo, Giuseppe: 1 article (11/2015)
8.	Terlizzi, Michela: 1 article (11/2015)
9.	Safdieh, Gabriella: 1 article (10/2012)
10.	Morgello, Susan: 1 article (10/2012)

Related Diseases

1.	Leukemia 07/01/1984 - "We find that recombinant human IFN-gamma induces expression of HLA-D antigens on human promyelocytic leukemia cells (HL-60) and enhances expression of HLA-D antigens on normal human monocytes and macrophages. " 01/01/1990 - "II. HLA-D expression in leukemia and non-Hodgkin's lymphoma]." 05/01/1981 - "The usage of only HLA-D identical related or unrelated donors in SCID revealed a 37% survival, compared to 18% survival in acute leukemia and 11% in severe aplastic anemia using HLA-phenotypical identical or HLA-D identical related donors. " 10/15/1977 - "In this study the frequency of a number of HLA-D antigens has been determined in normal individuals and in patients with four diseases selected in view of their genetic background: juvenile diabetes, multiple sclerosis, grass pollinosis and acute leukemia. " 09/01/1991 - "Surface expression of class II antigens (HLA-D) on B lymphocytes was studied in 47 patients with chronic lymphatic leukemia (CLL) with an aid of monoclonal antibodies against monomorphic determinants of DR, DP and DQ. "
2.	Aplastic Anemia (Anemia, Hypoplastic) 05/01/1981 - "The usage of only HLA-D identical related or unrelated donors in SCID revealed a 37% survival, compared to 18% survival in acute leukemia and 11% in severe aplastic anemia using HLA-phenotypical identical or HLA-D identical related donors. " 01/01/1980 - "The studies in SCID have demonstrated that HLA-D compatibility in spite of HLA-A or B incompatibilities can be tolerated and there is now accumulating evidence that even patients with aplastic anemia or acute leukemia can be successfully treated with such bone marrow grafts."
3.	Rheumatoid Arthritis 12/30/1983 - "In view of the role of HLA-D in the immune response, these studies are expected to further our understanding of the mechanism underlying predisposition for development of rheumatoid arthritis and related conditions." 02/01/1997 - "HLA-D region genes and susceptibility to rheumatoid arthritis." 08/01/1992 - "HLA-D region genes and rheumatoid arthritis." 01/01/1992 - "HLA-D region genes and rheumatoid arthritis (RA): importance of DR and DQ genes in conferring susceptibility to RA." 07/01/1991 - "HLA-D alleles in rheumatoid arthritis: comment on the article by Gao et al."
4.	Multiple Sclerosis 05/01/1995 - "Multiple sclerosis and the HLA-D region: linkage and association studies." 03/01/1982 - "HLA-D typing in multiple sclerosis: Israelis tested with European homozygous typing cells." 12/01/1978 - "An HLA-D-linked low response to polyclonal B-cell activation in multiple sclerosis." 04/01/1986 - "Association between HLA-D region epitopes and multiple sclerosis in Arabs." 03/01/1982 - "261 multiple sclerosis (MS) patients were HLA-A and -B typed and 94 were HLA-D typed. "
5.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1986 - "Further studies on psoriasis-associated HLA-Dw/DR7 using PLT cells primed against a familial psoriasis-linked HLA haplotype." 01/01/1986 - "The products of the HLA-D region and their correlation to psoriasis vulgaris was studied using the primed lymphocyte typing (PLT) assay. " 05/01/1978 - "The phenotype distribution of seven HLA--D alleles among 72 unrelated Psoriasis vulgaris patients was investigated. " 05/01/1978 - "HLA--D typing in 72 psoriasis vulgaris patients: distribution of seven HLA--D alleles." 05/01/1978 - "This observation indicates that Psoriasis vulgaris belongs to the group of diseases with associations to HLA--B as well as HLA--D alleles."

Related Drugs and Biologics

1.	HLA-A Antigens (HLA-A)
2.	HLA-DR Antigens (HLA-DR)
3.	HLA-DP Antigens (HLA-DP)
4.	Antigens
5.	Monoclonal Antibodies
6.	Histocompatibility Antigens Class II
7.	Immunoglobulin G (IgG)
8.	HLA-DQ Antigens (HLA-DQ)
9.	Autoantibodies
10.	Antibodies

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)