Histoplasmosis

Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)

Also Known As:

Networked: 1105 relevant articles (95 outcomes, 113 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS)
2.	Blastomycosis
3.	Coccidioidomycosis
4.	Macular Degeneration (Age-Related Maculopathy)
5.	Infection

Experts

1.	Wheat, L Joseph: 34 articles (08/2015 - 01/2002)
2.	Wheat, L J: 17 articles (04/2012 - 07/2000)
3.	Hage, Chadi A: 14 articles (11/2015 - 05/2003)
4.	Deepe, George S: 11 articles (01/2015 - 07/2003)
5.	Kauffman, Carol A: 10 articles (07/2014 - 07/2002)
6.	Connolly, Patricia: 10 articles (01/2012 - 01/2002)
7.	Nosanchuk, Joshua D: 8 articles (01/2012 - 09/2002)
8.	Connolly, P: 8 articles (12/2009 - 06/2000)
9.	McKinsey, David S: 6 articles (08/2015 - 07/2006)
10.	Nacher, Mathieu: 6 articles (11/2014 - 04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Histoplasmosis:

1.	Amphotericin B (Amphotericin)FDA LinkGeneric 10/01/2011 - "Treatment with amphotericin B is highly effective in histoplasmosis. " 03/01/1979 - "Complete remission of histoplasmosis was obtained with amphotericin B therapy." 02/01/1992 - "Successful therapy of histoplasmosis with amphotericin B is associated with reduction of HPA in body fluids. " 11/01/1990 - "The patient was treated for histoplasmosis with amphotericin B, which resulted in significant improvement of the oral lesions. " 04/01/1982 - "Ten years later, while still receiving immunosuppressive therapy, cutaneous histoplasmosis of the fingers developed, which was treated successfully with intravenous amphotericin B. "
2.	AntigensIBA 12/01/1990 - "The results pointed to an unexpectedly high degree of specificity of 91% and a sensitivity of 72%, comparable to figures from previous studies with other purified antigens; most of the false-positive results were for patients with histoplasmosis. " 09/01/1994 - "capsulatum antigen in urine is an important test in the diagnosis of disseminated histoplasmosis and is useful for assessing the efficacy of treatment. " 01/01/2007 - "Diagnostic accuracy has improved greatly with the use of an assay for Histoplasma antigen in the urine; serology remains useful for certain forms of histoplasmosis, and culture is the ultimate confirming diagnostic test. " 01/01/1994 - "Clearance of Histoplasma capsulatum variety capsulatum antigen is useful for monitoring treatment of experimental histoplasmosis." 12/01/2013 - "In summary, we conclude that while multiple assays are available for measuring histoplasma antigen in urine, a monoclonal-antibody-based assay appears to provide improved analytical performance for management of immunocompromised histoplasmosis patients. "
3.	Itraconazole (Sporanox)FDA LinkGeneric 11/01/1996 - "The results of this study indicate that itraconazole is effective for treatment of disseminated childhood histoplasmosis. " 11/01/2015 - "Follow-up histoplasmosis antibody titers were positive, and the patient responded well to itraconazole. " 11/01/1994 - "Although a limited number of cats were treated, the study suggests that itraconazole is a well-tolerated and effective drug for the treatment of histoplasmosis in the cat." 03/01/1989 - "A non-comparative open trial with itraconazole in progressive forms of human histoplasmosis was carried out. " 05/01/2015 - "We present a case of disseminated cutaneous histoplasmosis in a male patient, rural worker, HIV positive for 20 years, with a history of irregular use of antiretroviral therapy, T cell counts below 50 cells/mm3 and with good response to treatment with Itraconazole. "
4.	Ketoconazole (Nizoral)FDA LinkGeneric 11/01/1988 - "A case of disseminated histoplasmosis treated successfully with ketoconazole." 01/24/1983 - "Therefore ketoconazole appears safe and effective in the treatment of disseminated or progressive cavitary histoplasmosis in the noncompromised host. " 07/01/1989 - "Further studies on the treatment of African histoplasmosis with ketoconazole." 11/01/1990 - "Histoplasmosis of the larynx treated with ketoconazole: a case report." 12/01/1989 - "Six weeks after cessation of ketoconazole he died of what was thought to be relapse of histoplasmosis."
5.	Fluconazole (Zonal)FDA LinkGeneric 08/01/1994 - "The determination of fluconazole's role in therapy for histoplasmosis awaits completion of ongoing trials. " 01/01/2015 - "[Disseminated histoplasmosis treated by boluses of fluconazole]." 12/01/2012 - "Thus, fluconazole may be a viable alternative therapy for the treatment of feline histoplasmosis. " 12/01/2012 - "Feline histoplasmosis: fluconazole therapy and identification of potential sources of Histoplasma species exposure." 12/01/2001 - "Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome."
6.	ArgonIBA 09/01/1983 - "The Ocular Histoplasmosis Study (OHS) is a multicenter controlled clinical trial designed to determine whether argon laser photocoagulation is useful in preventing severe visual acuity loss in eyes with choroidal neovascular membranes (NVMs) 200 to 2,500 microns from the center of the foveal avascular zone and evidence of ocular histoplasmosis. " 08/01/1987 - "Prophylactic argon laser photocoagulation of the second eye in presumed ocular histoplasmosis syndrome." 07/01/1986 - "Accordingly, patients with ocular histoplasmosis and NVMs outside the fovea are advised to undergo prompt treatment with argon laser photocoagulation." 07/01/1986 - "The MPS documented that in patients with ocular histoplasmosis syndrome argon laser photocoagulation in comparison with no treatment can reduce the risk of severe visual loss from 46 to 13% in the first two years. " 09/01/1983 - "Argon laser photocoagulation for ocular histoplasmosis. "
7.	liposomal amphotericin BFDA Link 02/01/2009 - "Liposomal amphotericin B is the usual initial therapy for CNS histoplasmosis. " 08/01/1995 - "Liposomal amphotericin B therapy of murine histoplasmosis." 07/24/1995 - "Liposomal amphotericin B therapy in disseminated histoplasmosis." 04/01/1999 - "Successful therapy of disseminated histoplasmosis in AIDS with liposomal amphotericin B." 09/01/2011 - "We hereby report a short case of 71-year-old gentleman who developed ST segment elevation myocardial infarction shortly after starting the infusion of liposomal amphotericin B for disseminated histoplasmosis. "
8.	AntibodiesIBA 01/01/1985 - "The authors have looked for circulating antibodies on 168 subjects for the study of the prevalence of histoplasmosis in Mali. " 01/01/2015 - "Subsequent work up was positive for histoplasmosis yeast antibodies. " 10/01/2013 - "capsulatum antibodies was confirmed in three cases, our PCR method identified four of five cases of histoplasmosis. " 12/31/2009 - "Diagnosis of mild chronic pulmonary histoplasmosis was performed by histopathology of lung biopsy plus antibodies detection against H. " 06/01/2007 - "Therefore, rabbits immunized using the yeast-i.v. regimen produced the most sensitive antibodies with the highest titers for detection of C-Ag and antigenuria in histoplasmosis patients."
9.	KryptonIBA 02/01/1995 - "Among eyes in the Ocular Histoplasmosis Study--Krypton Laser with lesions less than 200 microns from the center of the foveal avascular zone, only 5% of eyes with laser treatment that covered the foveal side and had a narrow (< or = 100 microns) border of treatment to adjacent uninvolved retina experienced severe visual acuity loss compared with approximately 25% of eyes with either some of the foveal side of the lesion left untreated or a wide border of treatment on the foveal side. " 02/01/1981 - "Treatment of macular subretinal neovascularization with the red-light krypton laser in presumed ocular histoplasmosis syndrome." 03/01/1989 - "The 144 eyes assigned to krypton red laser photocoagulation in the Ocular Histoplasmosis Study-Krypton Laser were examined to describe persistence and recurrence in these patients. " 03/01/1989 - "Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of ocular histoplasmosis. " 11/01/1987 - "Krypton laser photocoagulation for neovascular lesions of ocular histoplasmosis. "
10.	bevacizumabFDA Link 11/01/2009 - "The purpose of this study was to assess the efficacy of intravitreal bevacizumab for choroidal neovascularization resulting from presumed ocular histoplasmosis syndrome. " 02/01/2012 - "To assess the long-term outcomes of intravitreal bevacizumab (IVB) in the treatment of choroidal neovascularization (CNV) secondary to presumed ocular histoplasmosis syndrome (POHS). " 02/01/2012 - "Analysis of outcomes for intravitreal bevacizumab in the treatment of choroidal neovascularization secondary to ocular histoplasmosis." 11/01/2009 - "This is a chart review of retrospective consecutive case series in which intravitreal bevacizumab (1.25 mg) was injected into 24 eyes with choroidal neovascularization resulting from presumed ocular histoplasmosis syndrome. " 11/01/2009 - "Intravitreal bevacizumab for choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome."

Therapies and Procedures

1.	Lasers (Laser) 04/01/1995 - "Long-term results of laser treatment in the ocular histoplasmosis syndrome." 06/01/1994 - "The authors found that subfoveal membranes from patients with AMD and the ocular histoplasmosis syndrome, whether occurring de novo or after laser treatment, have a nonuniform distribution of blood vessels, and that large areas which include the membrane margin may be avascular. " 08/01/1991 - "Among eyes with ocular histoplasmosis, untreated eyes (n = 130) had 3.6 times the risk of laser-treated eyes (n = 132) of losing six or more lines of visual acuity (P less than .0001). " 02/01/1984 - "Laser checks vision loss in histoplasmosis." 01/01/1995 - "A total of 113 eyes (112 patients) having either peripapillary CNV or CNV that was located nasal to the fovea and larger than 750 microns in longest diameter associated with either ocular histoplasmosis or idiopathic causes were identified from the eyes that were randomly assigned to either laser photocoagulation or observation only in clinical trials conducted by the Macular Photocoagulation Study Group. "
2.	Light Coagulation 07/01/1982 - "Photocoagulation in the treatment of presumed ocular histoplasmosis syndrome." 01/01/1981 - "Photocoagulation in presumed ocular histoplasmosis syndrome." 05/01/1979 - "System of notation for photocoagulation in the presumed ocular histoplasmosis syndrome." 03/01/1975 - "Photocoagulation of active and inactive lesions of presumed ocular histoplasmosis." 01/01/1975 - "For these reasons, conclusions as to the results of photocoagulation of the macular lesions in the ocular histoplasmosis syndrome must remain incomplete..."
3.	Photochemotherapy (Photodynamic Therapy) 12/01/2005 - "Small case series and clinical trials suggest excellent efficacy for photodynamic therapy in the treatment of subretinal neovascularization associated with presumed ocular histoplasmosis syndrome. " 09/01/2005 - "Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like)." 01/01/2005 - "Photodynamic therapy for juxtafoveal choroidal neovascularization due to ocular histoplasmosis syndrome." 12/01/2004 - "Photodynamic therapy of subfoveal and juxtafoveal choroidal neovascularization in ocular histoplasmosis syndrome: a retrospective case series." 06/01/2003 - "Although there is potential for patients with angioid streaks, ocular histoplasmosis syndrome, and idiopathic causes of choroidal neovascularization to benefit from photodynamic therapy, randomized clinical trials have not been performed. "
4.	Aftercare (After-Treatment) 01/01/2004 - "No deaths were attributed to histoplasmosis; outcomes after treatment are good." 01/01/1999 - "The two patients with ocular histoplasmosis experienced recurrence after treatment; one received further photocoagulation treatment, and the other underwent vitrectomy with removal of the CNVM. " 01/01/2000 - "Three patients had idiopathic extra hepatic portal vein thrombosis with cavernous transformation, 1 had thrombosis after a living-related liver transplant, and 1 had compression and obstruction of the main portal vein from enlarged lymph nodes after treatment of systemic histoplasmosis. " 10/15/1989 - "Long-term, intermittent maintenance amphotericin B therapy in HIV-infected patients with disseminated histoplasmosis is well tolerated and is highly effective in suppressing relapses after treatment." 01/01/2015 - "We report a case in which an HIV-infected man was cured of disseminated histoplasmosis (Histoplasma capsulatum var duboisii) after treatment by high-dose fluconazole (1,600 mg taken four times daily) for 2 months, combined with active antiretroviral therapy. "
5.	Drug Therapy (Chemotherapy) 08/01/2001 - "The surgical management and chemotherapy of histoplasmosis are briefly discussed." 10/01/1979 - "Experimental chemotherapy of histoplasmosis in nude mice." 03/01/1979 - "The subtle clinical and pathologic presentation might lead one to overlook the organisms and to believe that the leukemic process had progressed, resulting in potentially dangerous systemic involvement of histoplasmosis and unnecessary chemotherapy for his leukemic process. " 01/01/1960 - "Chemotherapy of experimental histoplasmosis." 06/01/1957 - "Experience with the course and chemotherapy of chronic pulmonary histoplasmosis."