Histones (Histone)

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.

Also Known As:

Networked: 6289 relevant articles (81 outcomes, 583 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Esteller, Manel: 38 articles (09/2015 - 12/2003)
2.	Rahman, Irfan: 20 articles (02/2014 - 05/2002)
3.	Garcia, Benjamin A: 18 articles (12/2015 - 11/2005)
4.	Barnes, Peter J: 16 articles (02/2014 - 01/2004)
5.	Dashwood, Roderick H: 16 articles (06/2013 - 08/2004)
6.	Marquez, Victor E: 16 articles (04/2013 - 01/2009)
7.	Akbarian, Schahram: 15 articles (10/2015 - 08/2005)
8.	Allis, C David: 15 articles (06/2015 - 04/2003)
9.	Hoffman, Robert M: 15 articles (05/2015 - 06/2004)
10.	El-Osta, Assam: 15 articles (01/2015 - 09/2004)

Related Diseases

1.	Neoplasms (Cancer) 06/20/2014 - "Bizine was found to be effective at modulating bulk histone methylation in cancer cells, and ChIP-seq experiments revealed a statistically significant overlap in the H3K4 methylation pattern of genes affected by bizine and those altered in LSD1-/- cells. " 02/15/2006 - "Treatment with Eg5 ASO produced a statistically significant reduction of tumor growth, reduction in Eg5 expression in the tumors, and changes in histone phosphorylation, consistent with a loss of Eg5 protein expression. " 09/01/2003 - "Histone H1 treatment significantly inhibited tumor growth, enhanced mean survival time and significantly improved the immune response and status. " 08/25/2005 - "(S)-11 at concentrations as low as 0.1 microM was effective in causing histone hyperacetylation and p21(WAF/CIP1) overexpression and suppressing proliferation in cancer cells." 09/01/2013 - "Preoperative detection of modified forms of histone H4 expression in tumor biopsies would be helpful in management of patients with HCC."
2.	Infection 02/26/2008 - "Genetic immunization of BALB/c mice with the individual histones only resulted in a delay in lesion development, whereas the immunization with any one of the plasmids encoding a pair of histones provided stronger, though still partial protection against Leishmania major infection compared to the combination of the four histones. " 10/20/2015 - "T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX." 01/01/2012 - "Experiments on Drosophila have shown that the histones that are normally bound to lipid droplets inside cells can be released to provide protection against infection." 01/01/2009 - "Since ASF1 mediates eviction and deposition of histones during transcription, the interaction of VZV IE63 with ASF1 may help to regulate transcription of viral or cellular genes during lytic and/or latent infection." 08/01/2015 - "The present work studies the consequences of HCV-induced histone modifications in early stages of infection. "
3.	Inflammation 06/01/2012 - "Immunohistochemical studies evaluated cell proliferation (histone H3 and Ki-67), microvessel density (CD31), and inflammation (CD45 and CD68). " 04/15/2011 - "Clinical studies demonstrated markedly increased global acetylation of histone 3 in the inflamed tissue of patients with allergic inflammation. " 01/01/2016 - "However, whether the mechanism by which TSA inhibits inflammation is through significantly enhancing histone acetylation, in order to selectively suppress the expression of proinflammatory genes, and/or through regulating non‑histone acetylation requires further research. " 12/15/2015 - "JMJD2B gene knockdown confirmed a critical role for this histone demethylase in mediating PCB-induced inflammation of the vascular endothelium. " 12/01/2015 - "Thus we conclude that histone acetylation contributes to the regulation of NR4A1 expression in hypercholesterolaemia, and that NR4A1 expression reduces hypercholesterolaemia-induced inflammation. "
4.	Sepsis (Septicemia) 01/01/2014 - "Our results suggest that the host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition. " 05/01/2015 - "The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular histones. " 10/01/2015 - "To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. " 10/01/2015 - "Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis." 09/01/2015 - "Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients."
5.	Proteinuria 06/01/1996 - "They responded well to the corticosteroid therapy, with a cytotoxic agent in one case, and the titers of anti-(histone-DNA) antibody was decreased along with the improvement of proteinuria. " 12/01/1992 - "Western blot analysis revealed antibodies to histone subfractions in sera of 33/34 lupus mice that developed proteinuria. " 04/15/1998 - "Of the BWgammaR(+/+) and +/- mice, 50% showed immune complex glomerulonephritis with heavy proteinuria at 8 mo of age, while only 10% of the BWgammaR(-/-) mice were affected at 14 mo. The serum concentration of anti-dsDNA and anti-histone Abs was dramatically reduced in BWgammaR(-/-) mice. " 02/01/2012 - "Laboratory tests showed anemia with leucopenia, hypocomplementemia, proteinuria, ANA positive at 1:320, and antibodies against dsDNA, Ro/SSA, La/SSB and histone. " 11/01/1994 - "While the level of antibodies to dsDNA, histones and core particles decreased significantly before the appearance of proteinuria, suggesting their involvement in glomerular injury, the longitudinal pattern of anti-U-H2A peptide response was apparently not linked to the manifestation of lupus nephritis in GVHD mice."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Lysine (L-Lysine)
3.	Chromatin
4.	Histones (Histone)
5.	Histone Deacetylase Inhibitors
6.	Antigen-Antibody Complex (Immune Complex)
7.	Antibodies
8.	Proteins (Proteins, Gene)
9.	MicroRNAs (MicroRNA)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Chemoprevention
2.	Oral Administration
3.	Transplantation (Transplant Recipients)
4.	Cystectomy
5.	Heterologous Transplantation (Xenotransplantation)