Histone Deacetylases (Histone Deacetylase)

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

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Networked: 5144 relevant articles (189 outcomes, 545 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McKinsey, Timothy A: 28 articles (02/2021 - 08/2002)
2.	Jung, Manfred: 20 articles (01/2022 - 06/2004)
3.	Atadja, Peter: 20 articles (02/2014 - 08/2003)
4.	Dashwood, Roderick H: 19 articles (03/2018 - 02/2006)
5.	Kee, Hae Jin: 18 articles (01/2022 - 01/2006)
6.	Chen, Ching-Shih: 18 articles (11/2017 - 08/2005)
7.	Olson, Eric N: 18 articles (03/2014 - 08/2002)
8.	Sippl, Wolfgang: 17 articles (04/2022 - 07/2015)
9.	Alam, Hasan B: 17 articles (01/2021 - 03/2006)
10.	Witt, Olaf: 17 articles (01/2021 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/15/2009 - "Global inhibition of class I and II histone deacetylases (HDACs) stops cancer cell proliferation in vitro and has proven effective against cancer in clinical trials, at least in part, through transcriptional reactivation of the p21(WAF1/Cip1)gene. " 12/01/2018 - "Epigenetic modification by inhibiting histone deacetylases (HDAC) is an emerging approach with promising results in cancer treatment. " 10/01/2008 - "In this mini-review, we provide an overview of the histone deacetylase superfamily, highlight the positive results of deacetylase inhibitors in cancer clinical trials, and comment on the prospects for the next generation of such inhibitors." 01/12/2006 - "Clinical trials are underway to evaluate the efficacy of inhibitors for class I and II histone deacetylases to treat malignancies. " 09/01/2022 - "Previous studies have confirmed differential histone deacetylase 5 (HDAC5) expression in various common tumors. "
2.	Breast Neoplasms (Breast Cancer) 12/15/2022 - "Effect of histone deacetylase 8 gene deletion on breast cancer cellular mechanism in vitro and in vivo study." 04/01/2020 - "In this study, we found that inhibition of the class I histone deacetylases (HDAC) exhibited synthetic lethality with BRCA1 deficiency in breast cancer cells. " 10/01/2019 - "Here we reviewed the mechanism and classification of histone deacetylases (HDACs), association between HDACs and breast cancer, classification and structure-activity relationship (SAR) of HDACIs, pharmacokinetic and toxicological properties of the HDACIs, and registered clinical studies for breast cancer treatment. " 02/01/2012 - "Our study suggests that LSD1 intimately interacts with histone deacetylases in human breast cancer cells. " 11/01/2023 - "We managed to explore the function of HFY-4A, a novel histone deacetylases (HDACs) inhibitor, on breast cancer as well as its potential mechanisms. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 11/07/2013 - "Targeting histone deacetylase (HDAC) in neuronal survival and neuroprotection may be beneficial in the treatment and prevention of neurodegenerative disorders. " 02/02/2011 - "Although it is well established that pharmacological inhibitors of classical histone deacetylases (HDACs) are protective in various in vivo models of neurodegenerative disease, the identity of the neurotoxic HDAC(s) that these inhibitors target to exert their protective effects has not been resolved. " 09/01/2022 - "Though the histone deacetylase 4 (HDAC4), HDAC5, HDAC7, and HDAC9 form class IIa of the HDAC superfamily have been found participating in multiple neurodegenerative diseases, while JNK signaling pathway activation was hypothesized as a key cause leading to cell apoptosis, the correlation between HDAC4 and JNK signaling pathway remains unknown. " 01/01/2022 - "Histone deacetylases (HDACs) mediate epigenetic mechanisms implicated in a broad range of central nervous system dysfunction, including neurodegenerative diseases and neuropsychiatric disorders. " 01/01/2022 - "Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective."
4.	Inflammation (Inflammations) 01/01/2023 - "Collectively, these data reveal a central role for an epithelial histone deacetylase in directing the dynamic balance of tissue-intrinsic CD4+ T cell subsets that recognize commensal microbes and control inflammation." 01/01/2023 - "Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease." 01/01/2023 - "The present results demonstrate aberrant metabolic switch in the skeletal muscle of PCOS animals, which is accompanied by excessive inflammation, oxidative stress and elevated levels of histone deacetylase and PDK4. " 12/20/2022 - "Histone deacetylases (HDACs) play important roles in immunity and inflammation. " 10/01/2022 - "Class IIa histone deacetylases (HDAC) have been shown to drive innate immune cell-mediated inflammation in the peripheral system, but their roles in cerebral inflammatory responses remain largely unknown. "
5.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2021 - "In addition, VPA acted as a radiosensitizer via the inhibition of histone deacetylase (HDAC) in a colorectal cancer organoid. " 01/01/2021 - "Importantly, tolinapant-induced apoptosis was augmented by FOLFOX in human colorectal cancer and murine organoid models in vitro and in vivo, due (at least in part) to FOLFOX-induced downregulation of class I histone deacetylases (HDAC), leading to acetylation of the FLIP-binding partner Ku70 and downregulation of FLIP. " 09/01/2020 - "Histone Deacetylase Modifications by Probiotics in Colorectal Cancer." 05/13/2020 - "However, the fine tune of histone deacetylases, especially the modification of histone deacetylases that facilitate colorectal cancer, remains elusive. " 03/01/2016 - "Histone deacetylases (HDACs) have been shown to regulate cell cycle, differentiation, and apoptosis of colorectal cancer (CRC) cells, while their roles in drug sensitivity remain unclear. "

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	DNA (Deoxyribonucleic Acid)
3.	Sirtuin 1
4.	Enzymes
5.	Vorinostat
6.	Methyltransferases
7.	Valproic Acid (Depakote)
8.	Proteins (Proteins, Gene)
9.	Antineoplastic Agents (Antineoplastics)
10.	trichostatin A (A 300)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Injections
5.	Aftercare (After-Treatment)