Histidine Decarboxylase

An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC 4.1.1.22.

Also Known As:

Networked: 283 relevant articles (4 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohtsu, Hiroshi: 20 articles (05/2015 - 08/2002)
2.	Falus, András: 9 articles (09/2010 - 08/2003)
3.	Chen, Zhong: 7 articles (08/2012 - 04/2003)
4.	Tanimoto, Akihide: 6 articles (04/2011 - 01/2003)
5.	Sasaguri, Yasuyuki: 6 articles (04/2011 - 01/2003)
6.	Watanabe, Takeshi: 6 articles (11/2009 - 04/2003)
7.	Bao, Ai-Min: 5 articles (07/2013 - 07/2011)
8.	Shan, Ling: 5 articles (07/2013 - 07/2011)
9.	Endo, Yasuo: 5 articles (11/2011 - 01/2003)
10.	Buzás, Edit: 5 articles (07/2007 - 08/2003)

Related Diseases

1.	Ulcer 12/01/1984 - "Our studies on the evaluation of some histidine decarboxylase inhibitors show that these compounds have a promising potential for developing an effective and safe anti-ulcer drug. " 12/01/1984 - "Histidine decarboxylase inhibition: a novel approach towards the development of an effective and safe gastric anti-ulcer drug." 08/01/1983 - "The gastric anti-ulcer activity of 3-methoxy-5,7,3',4'-tetrahydroxyflavan (ME), a specific histidine decarboxylase inhibitor, has been studied on a new experimental restraint rat model in which the ulcerogenic effect of 6 h restraint stress was augmented by the prior treatment with 50mg/kg p.o. " 12/01/1966 - "[Gastric histidine decarboxylase and experimental ulcers in rats]." 01/01/1983 - "The gastric anti-ulcer activity of naringenin, a specific histidine decarboxylase inhibitor."
2.	Hepatitis 09/01/2004 - "We examined a functional role of inducible histamine in the protection against hepatic injury and lethality in Propionibacterium acnes -primed and lipopolysaccharide-induced hepatitis, using histidine decarboxylase knockout and H2-receptor knockout mice. " 02/01/2008 - "In addition, from in vivo studies with histidine decarboxylase knockout and H(1)-, H(2)-receptor knockout mice, the protective effect of histamine against fulminant hepatitis is shown to be elicited through H(2)-receptor stimulation." 09/01/2004 - "The same dose of Propionibacterium acnes and lipopolysaccharide induced severe hepatitis and high lethality in histidine decarboxylase knockout and H2-receptor knockout mice; the former were rescued by the subcutaneous injection of histamine. "
3.	Colitis 01/01/2015 - "The ability of probiotic L. reuteri to suppress colitis depends on the presence of a bacterial histidine decarboxylase gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R). " 08/01/2004 - "Partial protection against dextran sodium sulphate induced colitis in histamine-deficient, histidine decarboxylase knockout mice." 01/01/2015 - "Only strains that possess the hdc gene cluster, including the histidine decarboxylase and histidine-histamine antiporter genes, can suppress colitis and mucosal cytokine (interleukin-6 [IL-6] and IL-1β in the colon) gene expression. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/01/2010 - "Utilizing the model of permanent middle cerebral artery occlusion (pMCAO) in mice, we found that carnosine significantly improved neurological function and decreased infarct size in both histidine decarboxylase knockout and the corresponding wild-type mice to the same extent. "
5.	Neoplasms (Cancer) 09/01/1970 - "A study on the induction of histidine decarboxylase in tumor-bearing rat." 09/01/1964 - "A ROTATING DIFFUSION CHAMBER FOR C14O2 DETERMINATION AS APPLIED TO INHIBITOR STUDIES ON MOUSE MAST CELL TUMOR HISTIDINE DECARBOXYLASE." 06/01/2015 - "In situ murine colon tumor model was established in histidine decarboxylase knockout (Hdc(-/-)) mice by chemicals induction. " 10/01/2005 - "We showed the up-regulation of histidine decarboxylase protein expression and activity in the tumor specimens when compared with normal colonic mucosa. " 06/01/2004 - "Histidine decarboxylase expression in pancreatic endocrine cells and related tumors."

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Carnosine
3.	Sodium
4.	Dextrans (Dextran)
5.	Messenger RNA (mRNA)
6.	Enzymes
7.	Transferases
8.	Gastrins
9.	Histidine (L-Histidine)
10.	Histamine Receptors (Histamine Receptor)

Related Therapies and Procedures

1.	Ligation
2.	Subcutaneous Injections
3.	Intravenous Infusions
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Transplantation (Transplant Recipients)