Histamine Antagonists (Antihistamines)

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.

Also Known As:

Networked: 2010 relevant articles (239 outcomes, 184 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maurer, Marcus: 13 articles (09/2015 - 03/2009)
2.	Mullol, J: 8 articles (01/2015 - 01/2007)
3.	Valero, A: 8 articles (01/2014 - 01/2007)
4.	Bielory, Leonard: 8 articles (09/2013 - 12/2002)
5.	Sastre, J: 7 articles (01/2014 - 01/2007)
6.	Bartra, J: 7 articles (01/2014 - 01/2007)
7.	Meltzer, Eli O: 7 articles (09/2013 - 04/2002)
8.	Ciprandi, Giorgio: 6 articles (01/2015 - 06/2003)
9.	Thurmond, Robin L: 6 articles (01/2015 - 11/2004)
10.	Jáuregui, I: 6 articles (01/2014 - 01/2007)

Related Diseases

1.	Rhinitis 12/01/1992 - "The older, classic antihistamines are effective in treating the symptoms of allergic rhinitis, but most are sedating because they cross the blood-brain barrier. " 12/01/2007 - "Oral antihistamines have proven efficacy in treating ocular symptoms of allergic rhinitis." 09/01/2001 - "In treating allergic rhinitis, the new second- and third-generation antihistamines have multiple advantages including rapid onset of action, extended duration of action, and efficacy for nearly all the symptoms that are produced by allergen sensitization. " 12/01/2007 - "Antihistamines are an established first-line treatment for allergic rhinitis and are widely prescribed in infants for allergic symptoms. " 04/01/2007 - "Intranasal and oral antihistamines are effective in treating allergic rhinitis. "
2.	Urticaria (Hives) 10/01/2015 - "At standard doses, several antihistamines are effective and safe in complete suppression of chronic spontaneous urticaria. " 01/01/2014 - "A significant proportion of patients with chronic urticaria respond inadequately to first line treatment with antihistamines. " 01/01/2013 - "Thus far, studies have demonstrated an increase in efficacy for refractory urticaria by increasing doses of antihistamines; however, more lines of supportive evidence for these guidelines are required to justify this management strategy. " 01/01/2009 - "Treatment and management of chronic urticaria can be non-pharmacological and pharmacological, and sometimes it is not possible to control the disease with antihistamines only, which are considered to be the mainstay of treatment. " 11/01/1994 - "For the majority of patients with chronic idiopathic urticaria, nonsedating antihistamines are the mainstay of treatment. "
3.	Pruritus (Itching) 05/01/2014 - "Topical antihistamines can generate rapid relief from acute symptoms and itching. " 11/20/2007 - "Desensitization was acutely successful in all 24 patients, and by 6-month follow-up, 1 patient had persistent but improved pruritus controlled with oral antihistamines and 23 remained asymptomatic, with only 2 patients requiring repeat desensitization. " 11/01/2014 - "Drug avoidance is the mainstay of treatment, and antihistamines can reduce associated pruritus. " 10/19/2011 - "In many diseases, pruritus is not effectively treated with antihistamines, indicating the involvement of nonhistaminergic mechanisms. " 08/01/2010 - "Of seven grade B trials, four supported the efficacy of topical antihistamines while three refute their use in relieving pruritus. "
4.	Hypersensitivity (Allergy) 09/01/2009 - "The review shows that antihistamines, the most frequently used class of anti-allergy medications, have been constantly improved, which is of significant importance for progress of allergic diseases treatment." 12/01/2008 - "Antihistamines are effective for treatment of seasonal nasal allergy. " 02/01/2008 - "This finding supports the hypothesis that ototopic antihistamines may prove effective in treating patients with allergy-induced eustachian tube dysfunction." 10/01/1995 - "Although desensitization was not effective, this allergic reaction was improved both by the treatment with oral antihistamines and desensitization. " 11/01/2009 - "The aim of the study was to assess management of patients with allergies, to evaluate frequency of use of specific antihistamines in population with diagnosed allergy, to evaluate causes and frequency of antihistamines' discontinuation, as well as frequency of allergen identification. "
5.	Asthma (Bronchial Asthma) 07/01/2003 - "As newer antihistamines with improved therapeutic indices have been developed, asthma studies can and must be conducted to evaluate high-dose therapy with the potential of reaping the anti-inflammatory and immunomodulatory effects of these drugs." 12/01/2002 - "Pharmacologic intervention with antihistamines led to significant reduction in incidence of asthma in high-risk children, but confirmatory longitudinal studies in large populations are necessary. " 01/01/2015 - "In patients with AR and comorbid asthma several physicians of all specialties -except pulmonologists- erroneously considers antihistamines, intranasal GCS and LTRAs useful for the treatment of asthma, while first-line recommended asthma treatment is inhaled GCS. " 09/01/1995 - "Antihistamines have been shown to be effective in patients with allergic asthma, but their role in chronic and more severe asthma is uncertain. " 03/01/2005 - "Mast cells have long been thought to play a central role in asthma through their ability to release proinflammatory mediators, but this role has been questioned by the lack of efficacy of antihistamines and so-called mast cell-stabilizing drugs. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Histamine (Histamine Dihydrochloride)
3.	Steroids
4.	Nasal Decongestants (Decongestants)
5.	Cetirizine (Zyrtec)
6.	Cholinergic Antagonists (Anticholinergics)
7.	omalizumab (Xolair)
8.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
9.	Epinephrine (Adrenaline)
10.	azelastine (Optivar)

Related Therapies and Procedures

1.	Immunotherapy
2.	Premedication
3.	Drug Therapy (Chemotherapy)
4.	Therapeutics
5.	Intradermal Injections