Hexobendine

A potent vasoactive agent that dilates cerebral and coronary arteries, but slightly constricts femoral arteries, without any effects on heart rate, blood pressure or cardiac output.

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Networked: 24 relevant articles (2 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Hypoxia (Hypoxemia) 10/01/1978 - "These alterations in cardiac metabolism induced by hypoxia were significantly improved by hexobendine given orally in doses of 10 approximately 100 mg/kg. Thus, hexobendine was shown to maintain the normal aerobic energy metabolism of the heart under states of hypoxia. " 06/01/1973 - "[Effect of hexobendine on the coronary efficacy of generalized hypoxia as well as of i.cor. " 03/01/1967 - "A comparison of the effects of hexobendine with those of anoxia on the concentration of myocardial metabolites in vivo." 10/01/1978 - "To elucidate the mode of action of hexobendine, its effects on some enzyme activities, the uptake of adenosine by rat erythrocytes and changes in the concentration of various myocardial substrates following induced hypoxia in rat were studied. " 01/01/1988 - "A combination of 30 mM 2-deoxyglucose and 2 micrograms of oligomycin/ml reduces the ATP content of the cells by 71% in 10 min. This change is accompanied by an increase in total adenosine concentration of 3.4 nmoles/10(7) cells in 10 min. Although the ATP concentration is not altered during hypoxia (95%N2/5%CO2), adenosine concentration increases by 0.52 nmoles/10(7) cells in 30 min. When nucleoside incorporation is inhibited by 85-90% by dipyridamole, dilazep or hexobendine, efflux of adenosine decreases by 70-90%, and 60-90% of the newly formed adenosine is trapped inside the cells compared to 10% in the absence of the transport inhibitors. "
2.	Angina Pectoris 08/10/1968 - "A double-blind trial of hexobendine in the treatment of angina pectoris." 11/17/1972 - "[Double-blind study on the effective oral dose of hexobendine in angina pectoris]." 02/11/1972 - "[Management of stenocardia using hexobendine]." 11/01/1970 - "[Use of ditrimine in angina pectoris]." 04/23/1965 - "[ON THE EFFECT OF N,N'-DIMETHYL-N,N'-BIS-(3-(3',4',5'-TRIMETHOXYBENZOXY)-PROPYL)-ETHYLENEDIAMINE (USTIMON) IN ANGINA PECTORIS]."
3.	Cerebrovascular Disorders (Cerebrovascular Occlusion) 04/01/1970 - "Effects of Hexobendine on cerebral blood flow and metabolism in cerebrovascular disease." 01/26/1968 - "[Studies of the administration of ustimon and instenon in cerebrovascular diseases]." 01/27/1967 - "[Indications for Ustimon and Instenon therapy in cerebrovascular diseases]."
4.	Coronary Disease (Coronary Heart Disease) 08/01/1968 - "[Clinical experiences with hexobendine in coronary disease]." 08/01/1968 - "[Experiences with hexobendine in the treatment of coronary diseases]." 06/15/1967 - "[Ustimon (ST 7090) in the treatment of coronary disease]."
5.	Stroke (Strokes) 03/01/1972 - "Regional cerebral blood flow and cariovascular effects of hexobendine in stroke patients." 04/01/1970 - "The effect of Hexobendine on regional cerebral blood flow in stroke patients."

Related Drugs and Biologics

1.	Instenon
2.	Dilazep
3.	Adenosine (Adenocard)
4.	Uridine
5.	Propranolol (Inderal)
6.	Procainamide (Procan)
7.	Oligomycins
8.	Nucleotides
9.	Nucleosides
10.	Nicergoline

Related Therapies and Procedures

1.	Therapeutics
2.	Exercise Therapy (Therapy, Exercise)