Hexachlorobenzene (HCB)

01/01/1980 - "Rats given CQ simultaneously from the beginning of the HCB feeding showed a significantly delayed onset of porphyria. "
07/01/1992 - "When administered simultaneously, MiBK reduced the severity of HCB-induced porphyria, but when given sequentially after HCB accumulation, it enhanced the porphyrinogenic response. "
07/15/1986 - "The results obtained show that DF improved the biochemical picture during HCB porphyria. "
08/21/2000 - "As a first step to elucidate the role of SM decrease in the hepatotoxicity induced by HCB, the present study evaluates the metabolic causes of the continuous decrease in hepatic SM content observed in Wistar rats with HCB intoxication, and its relation with porphyria development. "
04/01/1993 - "Instead, the present study points to the involvement of a putative reactive intermediate in the primary oxidative step in HCB-induced porphyria, since based on paired observations of individual rats, the degree of porphyria was correlated to a high degree with excretion of PCP, whereas correlation of porphyria with early excretion of TCHQ was much weaker. "

11/19/2015 - "These findings may help to understand the association among HCB exposure, angiogenesis and mammary carcinogenesis. "
11/19/2015 - "In this study, we examined HCB action on angiogenesis in mammary carcinogenesis. "
04/01/2011 - "The present study makes a significant contribution to the molecular mechanism of action of HCB in mammary carcinogenesis."
01/01/2019 - "We discuss the effects of environmentally relevant HCB concentrations on the normal mammary gland and different stages of carcinogenesis, and attempt to elucidate its mechanisms of action at molecular level. "
01/15/1979 - "Carcinogenesis of hexachlorobenzene in mice."

02/01/2015 - "Inflammation, oxidative stress, apoptosis, autophagy, and neuronal changes in receptor mosaics are several remote damage mechanisms that have been identified and examined using the HCb model. "
08/01/2018 - "The understanding of remote damage-associated mechanisms has been mostly achieved in several models of focal brain injury such as the hemicerebellectomy (HCb) experimental paradigm, which helped to identify the involvement of many key players, such as inflammation, oxidative stress, apoptosis and autophagy. "
01/01/2016 - "In conclusion, our results show that HCB exposure could contribute to endometriosis development, affecting inflammation and invasion parameters of human endometrial cells."
11/01/2022 - "In conclusion, the results demonstrated that co-treatment of HCB and Mn in rats' alleviated HCB-induced oxidative stress, inflammation and caspase-3 activation in the liver and kidney of the rats."
01/01/2021 - "Conversely, GW2580 treatment administered in adulthood after HCb was ineffective in reducing inflammation and cell death or improving functional recovery. "

06/01/2002 - "We conclude that MPA and HCB are safe and effective in the treatment of sunburn."
06/01/2002 - "Treated areas had significantly lower sunburn reaction than untreated areas (P = 0.1% and P = 0.5% for MPA and HCB, respectively). "
06/01/2002 - "This randomized, intra-individually controlled trial compared the efficacy and safety of two topical glucocorticosteroids, 0.1% methylprednisolone aceponate milk (MPA) and 0.1% hydrocortisone 17-butyrate emulsion (HCB), for treatment of sunburn in 24 healthy volunteers of skin type III. After irradiation of the skin by simulated sunlight, treatments were blinded and randomly allocated to 36 cm2 test areas on both sides of the spine. "

01/01/1986 - "Pre- and postnatal exposure to HCB resulted in renal maldevelopment in CD-1 mice and CD rats in terms of enlarged kidneys and hydronephrosis."
01/01/1992 - "Fetal body weight was slightly decreased in all groups dosed with greater than or equal to 250 mg HCB/kg. HCB did not induce cleft palate at a dose of 1000 mg/kg, but did induce increases in hydronephrosis and hydroureter at 500 and 1000 mg/kg. Combinations of HCB and TCDD decreased the incidence of cleft palate induced by TCDD alone, but only at doses of 15 micrograms TCDD/kg combined with 125-500 mg HCB/kg. The antagonism of hydronephrosis (incidence and severity) appeared over a narrower dose range (15 micrograms TCDD/kg + 500 mg HCB/kg). "
01/01/1986 - "Enlarged kidneys and hydronephrosis were observed in day-15 post-partum (pp) CD-1 mouse pups from dams treated with 10 or 50 mg hexachlorobenzene (HCB) per kg body weight (bw) on days 6-16 of gestation. "