Heterochromatin

04/01/2013 - "The expression of heterochromatin protein 1α/β in the kidney tumors: a microarray immunohistochemical study."
01/01/1986 - "Constitutive heterochromatin studies in patients with solid tumors."
08/01/1976 - "These findings differ from the results of biochemical analyses of heterochromatin both in cells during carcinogenesis and also in cancer cells, but are in agreement with qualitative and quantitative morphological studies of smeared cancer nuclei."
01/01/2015 - "Additionally, cancer-associated PTEN mutants lost their tumor-suppressor function when their heterochromatin structure was compromised. "
01/01/2015 - "Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure."

01/01/2011 - "In plants, they regulate gene expression and heterochromatin assembly, and control protection against virus infection. "
12/09/2015 - "Herpes simplex virus (HSV) reactivation from latent neuronal infection requires stimulation of lytic gene expression from promoters associated with repressive heterochromatin. "
01/01/2015 - "During lytic infection, KAP1 is still associated with the viral genome, but its heterochromatin-inducing activity is suppressed by mTOR-mediated phosphorylation. "
01/01/2013 - "Importantly, this transition to heterochromatin was dependent on both Polycomb Repressive Complex 1 and 2. In contrast, upon infection of human gingiva-derived epithelial cells, the KSHV genome underwent a transcription-active euchromatinization, resulting in efficient lytic gene expression. "
01/01/2009 - "Infection with Myc-tagged MECP2-isoform-specific (E1 and E2) vectors directed MeCP2 to heterochromatin of transduced NSC and neurons. "

04/01/2015 - "Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactive X chromosome, with highly abnormal 3D nuclear organization and global perturbations of heterochromatin, including gain of euchromatic marks and aberrant distributions of repressive marks such as H3K27me3 and promoter DNA methylation. "
04/01/2015 - "In conclusion, we observed epigenetic alterations (global genome hypomethylation, global hypoacetylation and accumulation of pericentric heterochromatin) in metastatic breast cancer cells of the 21 T series. "
01/01/2009 - "Moreover, we show that global heterochromatin defects observed in breast tumor cells are independent of BRCA1 status. "
01/01/2009 - "In addition, we evaluated the occurrence of broader defects of heterochromatin in relation to BRCA1 status in breast cancer cells. "
10/01/2008 - "Gene silencing may occur in breast cancer samples from patients presenting with occult metastatic cells in the bone marrow and one mechanism regulating gene suppression is heterochromatin formation. "

12/01/1994 - "Clustering of terminal deletions in the long arms of X chromosomes, which are entirely occupied by heterochromatin, suggests that chromosomal repair mechanisms responsible for rejoining of chromosomal breaks are less effective in heterochromatic than in other genomic regions."
08/01/2002 - "Then we monitored appearance of micronuclei during the passages since they are indicative of heterochromatin decondensation or chromosome breakage. "
01/01/2000 - "The loss of heterochromatin did not result in chromosome breakage, suggesting that heterochromatin may not be an integral part of chromosome structure, but rather a surface feature or covering."
01/01/1998 - "Using this FISH technique, significant nonlinear increases in hyperdiploidy were observed with both compounds, whereas no induction of chromosomal breakage affecting the pericentric heterochromatin regions of chromosomes 1, 9, and 16 could be detected. "
01/01/1992 - "Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin."

01/01/1989 - "The C-band heterochromatin polymorphism of chromosomes 1, 9, and 16 was studied in lymphocytes from 53 patients with Ph1-positive chronic myeloid leukemia (CML) and 183 control persons. "
07/01/1987 - "The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. "
12/01/1986 - "Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia."
04/01/2006 - "While the major epigenetic heterochromatin factor, histone H3 methylated at lysine 9, is present in all cell types, its main counterparts, nonhistone proteins, heterochromatin proteins 1 (HP1) alpha, beta, and gamma, are dramatically reduced in peripheral blood leukocytes of normal donors and chronic myeloid leukemia patients, but are substantially increased in the blood of accelerated phase and blast crisis patients. "