Herpesviridae Infections (Herpesvirus Infection)

02/01/2003 - "The anti-viral agent acyclovir is a specific inhibitor of herpesvirus replication, and the most effective agent for the treatment herpesvirus infection. "
09/01/1989 - "The two new compounds were demonstrated to be more potent against guinea pig lymphotropic herpesvirus infections than acyclovir. "
07/01/1990 - "Acyclovir possesses unique biologic properties that make it especially useful for the treatment of herpesvirus infections. "
01/01/1985 - "These data support the previous experience that i.v. acyclovir may be useful in the treatment of herpesvirus infections in immunocompromised patients."
12/01/1991 - "We evaluated the efficacy of acyclovir against experimentally induced herpesvirus infection (Pacheco's parrot disease) in Quaker parakeets. "

07/01/1991 - "Antiviral drugs have proven effective in treatment of herpesvirus infections and in prevention of reactivation of latent virus. "
10/01/2015 - "Antivirals with novel mechanisms of action are sought as additional therapeutic options to treat human herpesvirus infections. "
07/01/2014 - "Importance: Antivirals with novel mechanisms of action would provide additional therapeutic options to treat human herpesvirus infections. "
05/01/2014 - "Additionally, NFV may have therapeutic value alone or in combination with other antivirals in treating herpesvirus infections."
06/01/2005 - "The long-term treatment of herpesvirus infections with current antivirals leads to the development of drug-resistant viruses. "

08/01/1991 - "Our studies suggest a potential of HPMPC for conventional and prophylactic treatments of herpesvirus infections with infrequent drug administration."
01/01/2007 - "Potent inhibition of genital herpesvirus infection in goats by cidofovir."
11/01/2002 - "Cidofovir has also been used for the treatment of other herpesvirus infections, such as drug-resistant varicella-zoster virus, and Epstein-Barr virus-induced proliferative diseases. "
11/01/2008 - "The efficacy of cidofovir against caprine herpesvirus infection was higher when the treatment was started shortly after infection than when lesions were already present and advanced. "
07/01/2015 - "Cidofovir is often used as a first-line agent for adenovirus infections, despite the absence of randomized controlled trials with HSCT patients, and as a second-line agent for resistant herpesvirus infections. "

06/01/1990 - "Comparative therapeutic efficacy of recombinant interferons-alpha, -beta, and -gamma against alphatogavirus, bunyavirus, flavivirus, and herpesvirus infections."
01/01/1987 - "Reevaluation of human alpha interferons against herpesvirus infection of the rabbit eye."
02/01/1986 - "Effect of antibody to interferon on genital herpesvirus infection in mice."
12/01/1984 - "Thus presurgical treatment with interferon alone may actually precipitate and accentuate herpesvirus infection."
01/01/1982 - "Several chemicals and interferons have been utilized in the prophylaxis and the treatment of a number of human herpesvirus infections. "

06/01/1993 - "These results indicate that induction of interferon alpha/beta appears to be a major mechanism for both natural resistance and pICLC-induced antiviral protection against MCMV and HSV-2 herpesvirus infections."
07/01/1986 - "The efficacy of a novel consensus form of human alpha interferon designated IFN-alpha Con1 was evaluated against herpesvirus infections in vitro and in vivo. "
03/01/1982 - "Natural and cloned human leukocyte interferon in herpesvirus infections of rabbit eyes."

07/01/1985 - "The finding, however, that one mar mutation in gC affected both CTL and antibody recognition of this antigen may help to define antigenic sites important to both humoral and cell-mediated immunity to herpesvirus infection."
08/01/2012 - "CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. "
01/01/2008 - "It is suggested that the ELISA with the recombinant antigens is useful not only for the serodiagnosis of primate herpesvirus infections but also for elucidation of the seroprevalence of herpesviruses in humans and primates."
12/01/2007 - "Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection."
09/01/2003 - "The molecular characterization of the epitope repertoire on herpes simplex virus (HSV) antigens would greatly expand our knowledge of HSV immunity and improve immune interventions against herpesvirus infections. "

10/01/1983 - "The pharmacokinetics of vidarabine were studied on 22 occasions in nine infants and three older children with herpesvirus infection. "
11/01/1980 - "The advantage of increased solubility will lead to controlled clinical investigations in which vidarabine 5'-monophosphate is administered by intramuscular or intravenous routes against targeted human herpesvirus infections."
01/01/1979 - "Developmental aspects of adenine arabinoside for parenteral therapy of human herpesvirus infections."
12/01/1978 - " activity (AVA) was assayed as ara-A equivalents in sera and urines from 10 patients with serious herpesvirus infections who received 2.5-20 mg/kg daily of ara-A by intramuscular or intravenous routes. "
03/04/1977 - "Comparing the combination to vidarabine alone, a significant increase (10-fold) of the antiviral activity of the combined drugs was observed against herpes and vaccinia viruses in tissue culture and subcutaneously, against cranial herpesvirus infections in mice. "

05/01/1978 - "This study does not support earlier suggestions that levamisole, in these doses, is useful in the treatment of recrudescent circumoral herpesvirus infections."

05/01/2010 - "Foscarnet-induced genital erosions have been reported in patients treated for HIV-related herpesvirus infections in adults. "
09/01/1978 - "Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs."
01/01/1992 - "Foscarnet therapy for AIDS-related opportunistic herpesvirus infections."
04/01/1982 - "Assessment of phosphonoformate-treatment of pigeon herpesvirus infection in pigeons and budgerigars and Aujeszky's disease in rabbits."
02/01/2005 - "Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. "

07/01/2002 - "The detection of viral DNA by PCR technique has become the "gold standard" method for laboratory diagnosis of herpesvirus infections of CNS. "
02/01/2012 - "The formation of replication compartments, the subnuclear structures in which the viral DNA genome is replicated, is a hallmark of herpesvirus infections. "
12/08/2006 - "Upon herpesvirus infection, viral DNA becomes associated with nuclear structures known as nuclear domain 10 (ND10). "
09/01/2003 - "CHPKs demonstrate specific activity in multiple herpesvirus infections, functioning in the regulation of viral gene expression in HSV-1, tissue tropism in VZV, and viral DNA synthesis, encapsidation and egress from the nucleus in HCMV. "
05/01/1997 - "The enhancement of oriL-dependent DNA replication by DEX in differentiated PC12 cells suggests the possibility that glucocorticoids, agents long recognized to enhance reactivation of latent herpesvirus infections, act through the GRE in oriL to stimulate viral DNA replication and reactivation in terminally differentiated neurons in vivo."

06/01/2011 - "Herpesvirus infections cause morbidity in lung transplant recipients. "
12/01/2003 - "Herpesvirus infections are common causes of morbidity and mortality in solid organ and haematopoietic stem cell transplant recipients. "
12/01/2003 - "Despite recent great advances in transplantation techniques, herpesvirus infections remain a major cause of morbidity and mortality in transplant recipients. "
02/01/2001 - "These findings may have implications for those transplant recipients that receive MMF as (part of) their immunosuppressive therapy and that develop intercurrent herpesvirus infections for which they need treatment."
01/01/2001 - "Prophylaxis against herpesvirus infections in transplant recipients."

03/01/2001 - "The concept of using immunotherapy to treat recurrent herpesvirus infections dates back to the 1930s, although many of the initial studies were seriously flawed. "
03/01/2001 - "Potential for immunotherapy in the treatment of herpesvirus infections."
03/01/1986 - "The data suggest that cyclosporine treatment inhibits the activation of suppressor cells and depression of cellular immune function that have been associated with herpesvirus infections in renal transplant recipients undergoing conventional immunotherapy."

02/01/2013 - "Understanding the immune parameters that control herpesvirus infection, and the strategies the viruses use to evade immune recognition, has been critical in understanding why immunological dysfunction in transplant patients can lead to disease, and in the development of immunological strategies to prevent and control herpesvirus associated diseases."
10/15/2005 - "Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease."
01/01/2003 - "[Clinical picture of Herpesviridae infections among immunocompromised patients: bone marrow and solid organ transplants recipients]."
01/01/2003 - "Herpesvirus infections in organ transplant recipients."
01/01/2001 - "Herpesvirus infections are important after stem cell and organ transplant. "

04/29/2001 - "MHV-68 provides an excellent model to explore methods for controlling gamma-herpesvirus infection through vaccination and chemotherapy. "
01/01/1998 - "This characteristic makes antiviral chemotherapy an indispensable weapon in the management of recurrent herpesvirus infection."
01/01/1995 - "[The principles of the pathogenetic antiherpetic chemotherapy of acute and recurrent herpesvirus infections]."
10/01/1993 - "[New approaches to the chemotherapy of herpesvirus infections]."
11/01/1990 - "[Herpesvirus infections--indications for chemotherapy in dermato-venereology]."

09/01/1993 - "[The diagnosis of herpesvirus infection in patients with organ allografts]."
07/01/1992 - "[The effect of herpesvirus infections on the results of a kidney allograft]."
09/01/1985 - "We conclude that the etiologic agents and clinical features of herpesvirus infections are similar in pediatric and adult renal allograft recipients. "
09/01/1985 - "Herpesvirus infections were responsible for allograft loss in 7 (24%) patients. "
05/01/1984 - "Herpesvirus infection of cornea allografts."