Pemphigoid Gestationis (Herpes Gestationis)

An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).

Also Known As:

Networked: 219 relevant articles (4 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bullous Pemphigoid (Pemphigoid)
2.	Dermatitis Herpetiformis (Disease, Duhring's)
3.	Pemphigus (Pemphigus Vulgaris)
4.	Skin Diseases
5.	Porphyrias

Experts

1.	Zillikens, Detlef: 9 articles (02/2012 - 01/2002)
2.	Sitaru, Cassian: 5 articles (04/2015 - 01/2002)
3.	Schmidt, Enno: 5 articles (02/2012 - 01/2002)
4.	Zillikens, D: 5 articles (12/2004 - 01/2000)
5.	Tasanen, Kaisa: 3 articles (05/2015 - 04/2008)
6.	Huilaja, Laura: 3 articles (05/2015 - 04/2008)
7.	Hashimoto, Takashi: 3 articles (04/2015 - 11/2002)
8.	Ambros-Rudolph, Christina M: 3 articles (10/2014 - 03/2006)
9.	Rose, Christian: 3 articles (06/2010 - 11/2002)
10.	Wojnarowska, F: 3 articles (12/2004 - 11/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pemphigoid Gestationis:

1.	Immunoglobulin A (IgA)IBA 06/01/1989 - "Placentae from seven patients with pemphigoid gestationis (PG) and two patients with linear IgA disease were studied. " 06/01/1989 - "Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease." 09/01/2014 - "The pemphigoid-like diseases include mucous membrane pemphigoid, pemphigoid gestationis and linear IgA disease. " 12/01/2004 - "NC16A domain-specific T cells have been identified in the blood of individuals with bullous pemphigoid (BP), pemphigoid gestationis and linear IgA disease, but there are no data investigating the potential role for such T cells in the pathogenesis of MMP. " 03/01/1988 - "Palmo-plantar involvement in auto-immune blistering disorders--pemphigoid, linear IgA disease and herpes gestationis."
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2004 - "We present the clinical case of a 38 year-old woman to whom a case of Herpes Gestationis was diagnosed when she was 15 weeks pregnant and whom has been treated with corticosteroids and antihistamine's showing positive results and without major complications for the mother or the embryo. " 01/01/2011 - "The patient with pemphigoid gestationis was subsequently treated with systemic corticosteroids until the symptoms of her self-limited disease ceased. " 11/01/2004 - "Moreover, we underline the efficiency of topical class I corticosteroids in the treatment of pemphigoid gestationis." 05/01/2001 - "Severe form of pemphigoid gestationis are currently treated with 0.5 to 1 mg/kg/day of systemic corticosteroids, with maternal and pediatric possible side effects. " 01/01/1998 - "[Herpes gestationis--oral corticosteroids cannot be avoided]."
3.	Ritodrine (Yutopar)FDA Link 11/01/1984 - "Ritodrine therapy associated with remission of pemphigoid gestationis." 05/01/1988 - "Herpes gestationis and ritodrine." 01/01/1986 - "Ritodrine and pyridoxine in herpes gestationis."
4.	rituximab (Mabthera)FDA Link 08/01/2007 - "Severe persistent pemphigoid gestationis: long-term remission with rituximab."
5.	AntigensIBA 01/01/1988 - "Abnormal expression of class II MHC antigens was consistently observed in an immunohistological study on placentae from patients with pemphigoid gestationis. " 07/01/1994 - "We report a severe case of pemphigoid gestationis (PG) with an unusual target antigen. " 07/01/1994 - "Severe case of pemphigoid gestationis with unusual target antigen." 01/01/1992 - "The heterogeneity of immunofluorescence patterns may correspond to the heterogeneity of antigen recognition by different patients with pemphigoid gestationis." 01/01/1992 - "Pemphigoid gestationis-related antigen is expressed by isolated basal keratinocytes and is resistant to trypsinization. "
6.	Pruritic urticarial papules plaques of pregnancyIBA 12/01/2013 - "The edematous papules and plaques of pemphigoid gestationis may be particularly difficult to distinguish from polymorphic eruption of pregnancy; therefore, immunofluorescence studies are prudent. " 09/01/1983 - "A comparative histopathological study of polymorphic eruption of pregnancy and herpes gestationis." 02/01/1983 - "An immunoelectron microscopy study of the relationship between herpes gestationis and polymorphic eruption of pregnancy." 07/01/1996 - "We report two unusually florid cases of polymorphic eruption of pregnancy (PEP) or pruritic urticarial papules and plaques of pregnancy, the first occurring in a triplet pregnancy, and the second with some clinical features more suggestive of pemphigoid gestationis (PG). " 02/01/1983 - "Although there is a considerable clinical and histopathological overlap between herpes gestationis and polymorphic eruption of pregnancy our findings indicate that these conditions are pathogenetically distinct and should be classified as separate disorders."
7.	Complement System Proteins (Complement)IBA 01/01/1978 - "Herpes gestationis: studies on the binding characteristics, activity and pathogenetic significance of the complement-fixing factor." 07/01/1973 - "This study provides suggestive evidence that activation of complement is occurring via the alternate pathway in herpes gestationis. " 10/01/1993 - "Complement polymorphism in herpes gestationis: association with C4 null allele." 05/01/1989 - "Tissue damage in pemphigoid gestationis is apparently mediated by complement fixation which is detected via the classical complement cascade." 08/01/1987 - "The results demonstrated that the complement fixation antibody (herpes gestationis factor) could bind to the basement membrane zone of skin, amnion and chorion laeve but not to that of the placental syncytiotrophoblast. "
8.	Immunoglobulin G (IgG)IBA 10/01/1991 - "Our study indicates that in herpes gestationis the cleavage, accompanied by IgG, C3 and immunocomplex deposition, occurs at the level of the sub-basal dense plate. " 02/01/1997 - "We describe a case of clinically typical pemphigoid gestationis with the combination of intercellular IgG and BMZ IgG and C3 staining on immunofluorescence, a pattern which is unique for this condition." 05/01/1989 - "IgG1 was found to be the major IgG subclass in both serum and tissue, being detected in the sera of all pemphigoid gestationis patients studied. " 05/01/1989 - "The distribution of IgG subclasses in pemphigoid gestationis: PG factor is an IgG1 autoantibody." 06/01/1985 - "Indirect immunofluorescence can be used to demonstrate the so-called herpes gestationis factor (HGF), a heat stable immunoglobulin G (IgG), in the maternal and foetal blood. "
9.	AutoantibodiesIBA 03/01/2012 - "A case of herpes gestationis: follow-up study of autoantibodies using enzyme-linked immunosorbent assay and immunoblotting." 04/15/1999 - "Autoantibodies associated with herpes gestationis (HG), a pregnancy-associated autoimmune skin disease, target the hemidesmosomal protein BP180. " 09/01/1995 - "BP180 is a 180kDa hemidesmosomal protein recognized by bullous pemphigoid (BP) and pemphigoid gestationis (PG) autoantibodies. " 06/01/1994 - "Autoantibodies associated with the subepidermal blistering disorders bullous pemphigoid and herpes gestationis react with a 180-kD transmembrane hemidesmosomal protein, designated BP180. " 06/01/1994 - "Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis."
10.	AntibodiesIBA 06/01/2009 - "In 5% to 10% of cases, the antibodies responsible for gestational pemphigoid are transferred to the neonate through the placenta, causing transitory blistering in the neonate. " 04/01/1996 - "We examined 42 herpes gestationis sera with immunofluorescence of normal human skin sections, and found that anti-keratinocyte cell surface antibodies were detected specifically in 10 herpes gestationis sera. " 04/01/1996 - "Specific detection of anti-cell surface antibodies in herpes gestationis sera." 11/01/1983 - "It has been suggested that anti-HLA antibodies might be involved in the pathogenesis of herpes gestationis (HG). " 01/01/1980 - "[Herpes gestationis: antibasal cell antibodies in five out of sixteen cases (author's transl)]."

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 10/01/1998 - "The authors report an original case of large cutaneous necrosis of the abdominal wall following a first cesarean section in a patient with a background of pemphigoid gestationis. " 05/01/1996 - "Seven days after emergency Caesarean section for pre-eclampsia, she developed a pruritic blistering eruption which clinically resembled pemphigoid gestationis. "
2.	Intensive Care (Surgical Intensive Care) 01/01/1984 - "In view of this it is essential that patients with pemphigoid gestationis are delivered in maternity units which have facilities for intensive care of the newborn."
3.	Epidural Analgesia 09/01/1990 - "A 23-yr-old parturient with herpes gestationis spontaneously delivered a normal healthy infant under epidural analgesia. " 09/01/1990 - "Epidural analgesia for a parturient with herpes gestationis."
4.	Plasma Exchange 10/18/1980 - "Plasma exchange in herpes gestationis."
5.	Ovariectomy (Oophorectomy) 11/01/1992 - "Pemphigoid gestationis--response to chemical oophorectomy with goserelin."