Ventral Hernia

A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.

Also Known As:

Networked: 1253 relevant articles (53 outcomes, 168 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hernia (Hernias)
2.	Wounds and Injuries (Trauma)
3.	Postoperative Pain
4.	Pain (Aches)
5.	Surgical Wound Infection

Experts

1.	Heniford, B Todd: 31 articles (03/2022 - 10/2000)
2.	Rosen, Michael J: 23 articles (01/2022 - 12/2006)
3.	Carbonell, Alfredo M: 15 articles (01/2022 - 08/2003)
4.	Augenstein, Vedra A: 14 articles (03/2022 - 07/2015)
5.	Kercher, Kent W: 14 articles (01/2022 - 10/2002)
6.	Dumanian, Gregory A: 14 articles (10/2021 - 03/2003)
7.	Matthews, Brent D: 14 articles (02/2012 - 10/2000)
8.	Butler, Charles E: 13 articles (11/2022 - 08/2004)
9.	Fischer, John P: 13 articles (01/2022 - 03/2014)
10.	Liang, Mike K: 13 articles (01/2022 - 09/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ventral Hernia:

1.	Polypropylenes (Polypropylene)IBA 03/01/2014 - "This study showed that a surgically prepped vaginal canal can be a sterile conduit for insertion of polypropylene mesh for transvaginal ventral hernia repair without the use of additional mesh protection. " 10/01/2009 - "This study evaluates management of giant ventral hernias using polypropylene mesh and host tissue barrier after suitable preoperative preparation. " 10/01/2009 - "Management of giant ventral hernia by polypropylene mesh and host tissue barrier: trial of simplification." 11/01/2006 - "The purpose of this study was to assess the burst strength and stiffness of heavy weight (HW), mid-weight (MW), and light weight (LW) polypropylene mesh pre-implantation and 5 months post-implantation in a porcine ventral hernia model. " 01/01/2023 - "Mediumweight (MW) and heavyweight (HW) polypropylene have demonstrated similar clinical and patient-reported outcomes in the setting of open retromuscular ventral hernia repair (VHR). "
2.	Polytetrafluoroethylene (Teflon)FDA Link 12/01/2016 - "Objective This study investigated the use of prosthetic condensed polytetrafluoroethylene (cPTFE) for laparoscopic ventral hernia repair (LVHR) in an outpatient community-hospital setting. " 06/01/2005 - "The purpose of this study is to evaluate fixation methods for polytetrafluoroethylene (ePTFE) mesh with an in vivo model of laparoscopic ventral hernia repair. " 05/01/2000 - "Between 1993 and 1998, we performed a linear study of laparoscopic ventral hernia repair performed in a standard fashion using expanded polytetrafluoroethylene on 49 patients. " 01/01/2016 - "Ten patients with Ventral Hernia Working Group types 3 and 4 were prospectively enrolled and subsequently treated with direct supported repairs with condensed fenestrated polytetrafluoroethylene mesh. " 01/01/2016 - "Prospective repair of Ventral Hernia Working Group type 3 and 4 abdominal wall defects with condensed polytetrafluoroethylene (MotifMESH) mesh."
3.	Analgesics (Analgesic Drugs)IBA 04/01/2017 - "The analgesic efficacy of pre-operative bilateral erector spinae plane (ESP) blocks in patients having ventral hernia repair." 11/01/2020 - "Our institution implemented a standard protocol for prescribing analgesics at discharge after ventral hernia repair (VHR). " 10/01/2017 - "Postoperative analgesic efficiency of transversus abdominis plane block after ventral hernia repair: a prospective, randomized, controlled clinical trial." 04/01/2023 - "Laparoscopic-guided TAP-block can be considered safe and effective in the management of post-operative pain and in the reduction of analgesic need in patients undergoing laparoscopic repair of diastasis recti and ventral hernias. " 12/01/2021 - "The use of analgesics was higher in patients with incisional/ventral hernia as compared with those with inguinal hernia (1.48 [0.54] vs. 1.31 [0.51], P = 0.021). "
4.	tetra-4-amidinophenoxypropane (TAPP)IBA 04/01/2018 - "Our study results support the safe and effective placement of mesh in the preperitoneal space via the use of robotic technology, and they represent the largest single-surgeon series of robotic-assisted TAPP ventral hernia repair. " 05/28/2020 - "We review the operative considerations, intraoperative approach, and current body of literature related to robotic-assisted TAPP ventral hernia repair and conclude that it is feasible and may result in improved outcomes related to the restoration of abdominal wall anatomy and reduced operative costs. " 05/28/2020 - "Further studies are needed to assess if robotic-assisted TAPP should become the standard approach for repair of ventral hernia defects." 10/01/2019 - "The aim of this study was to compare perioperative results of robotic IPOM (r-IPOM) and robotic TAPP (r-TAPP) in ventral hernia repair, and to identify risk factors associated with postoperative complications. " 07/01/2011 - "Before we label the TAPP repair of ventral hernia as the first choice, a comparative multicentric prospective trial with IPOM repair is warranted."
5.	Type A Botulinum Toxins (Botox)FDA Link 01/01/2022 - "the botulinum toxin A (BTA) has been used to achieve a chemical component separation, and it has been used with favorable outcomes for the repair of complex ventral hernia (CVH) with and without loss of domain (LD). " 01/01/2022 - "This invited article reports the observational experience gained from the functional abdominal wall CT examinations of 88 patients who underwent complex ventral hernia repair using pre-operative Botulinum toxin A (BTA) infiltration of the lateral oblique abdominal muscles as well as a further eight patients with diastasis rectus abdominis who were examined to exclude ventral hernia. " 01/01/2022 - "To assess 7-year outcomes after complex ventral hernia (CVH) repair using pre-operative Botulinum toxin A (BTA) injection and the Macquarie System of management. " 09/01/2021 - "To facilitate fascial closure in massive ventral hernias preoperative Botulinum Toxin A (BTA) injection can be used. " 01/01/2021 - "Botulinum Toxin A Facilitated Laparoscopic Repair of Complex Ventral Hernia."
6.	AllodermIBA 01/01/2021 - "Addition of platelet-rich plasma supports immune modulation and improved mechanical integrity in Alloderm mesh for ventral hernia repair in a rat model." 10/01/2013 - "From January 2005 to December 2007, 55 patients with a complicated ventral hernia were repaired with AlloDerm (Life Cell Corporation). " 01/01/2008 - "We reviewed all patients who underwent repair of massive ventral hernias and identified 7 patients who presented with abdominal wall laxity following component separation with interpositional Alloderm alone. " 11/01/2007 - "The ideal technique for the use of AlloDerm (LifeCell Corp) in complicated ventral hernia repair has not been defined. " 12/01/2008 - "Surgical management included early definitive abdominal closure (EDAC, n = 56; 67%), primary fascial closure (n = 15; 18%), planned ventral hernia (PVH, n = 9; 11%) and vacuum-assisted closure with AlloDerm (n = 3; 4%). "
7.	Opioid Analgesics (Opioids)IBA 01/01/2023 - "We sought to assess opioid utilization and patient-reported outcomes (PROs) in patients undergoing ventral hernia repair (VHR) following the implementation of a patient-tailored opioid prescribing guideline. " 01/01/2023 - "Implementation of a Patient-Tailored Opioid Prescribing Guideline in Ventral Hernia Surgery." 11/01/2020 - "Implementation of an Evidence-Based Protocol Significantly Reduces Opioid Prescribing After Ventral Hernia Repair." 08/01/2020 - "Opioid Use After Inguinal and Ventral Hernia Repair." 01/01/2019 - "We previously reported a significant reduction in opioid consumption after implementation of an Enhanced Recovery after Surgery protocol after ventral hernia repair focusing on opioid reduction. "
8.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/2019 - "Closed suction drains (CSD) are commonly used in ventral hernia repair (VHR), with or without prolonged postoperative prophylactic antibiotics (PPA) for the duration of their use. " 02/01/2014 - "Macroporous lightweight meshes, combined with use of prolonged suppressive antibiotics and sublay retromuscular mesh placement that provides complete tissue coverage, should be further investigated as an acceptable prosthetic choice when planning a complex ventral hernia repair in the setting of prior MRSA SSI." 03/01/2005 - "A short delay of 2 to 6 days with antibiotic coverage is a safe strategy for managing potential or recognized injury to the gastrointestinal tract during laparoscopic ventral hernia repair." 08/13/2013 - "She underwent a complicated yet successful treatment course including surgical mesh removal (with a peri-operative complication), implantation of a biological mesh for the ventral hernia defect and ultimately, antibiotics tailored to the offending pathogen identified by postoperative culture of the infected mesh. " 03/01/2013 - "We evaluate the efficacy of soaking mesh in antibiotics to prevent prosthetic infection in an animal model of clean-contaminated ventral hernia repair (VHR). "
9.	parietexIBA 03/01/2007 - "Laparoscopic ventral hernia treatment using Parietex composite mesh is an effective and safe procedure. " 01/01/2020 - "This study assessed the 6-month outcomes of a single surgeon's cohort of ventral hernia repairs performed with either GORE BIO-A (BioA) or Parietex ProGrip (ProGrip). " 01/01/2015 - "This preclinical study compares the behavior of a new mesh (Parietex composite ventral patch [Ptx]) with that of two existing meshes used for ventral hernia repair. " 03/01/2007 - "The authors describe a minimally invasive treatment of moderate to large incisional and ventral hernia defects using Parietex composite mesh. " 10/01/2009 - "One patient with a remote history of methicillin-resistant Staphylococcus aureus (MRSA) mesh infection underwent laparoscopic ventral hernia repair with a 20 x 23-cm piece of Parietex composite mesh. "
10.	GlucocorticoidsIBA 01/01/2020 - "Although preoperative administration of high-dose glucocorticoid may lead to improved recovery after operative procedures, this regimen has not been examined in patients undergoing abdominal wall reconstruction for repair of large ventral hernias. " 08/01/2016 - "Even so, studies on administration of glucocorticoids for patients undergoing abdominal wall reconstruction (AWR) for giant ventral hernia repair are lacking, perhaps due to a fear of impaired wound healing. " 04/01/2016 - "The current study suggests that an ERAS pathway including preoperative high-dose glucocorticoid may lead to low scores of pain, fatigue and nausea after giant ventral hernia repair with reduced LOS compared with patients treated according to SC."

Therapies and Procedures

1.	Length of Stay 12/01/2006 - "Laparoscopic repair of incisional and ventral hernias is superior to open mesh repair in terms of significantly less blood loss, fewer complications, shorter hospital stay, and excellent cosmetic outcome." 05/22/2023 - "For patients undergoing first-time repair of a ventral hernia, robot-assisted retromuscular repair was associated with a significantly reduced incidence of prolonged length of postoperative hospital stay and risk of 90-day compared to laparoscopic IPOM." 01/01/2015 - "Laparoscopic ventral hernia mesh repair has gained wide popularity with the benefits of shorter hospital stay, improved patient outcome, and fewer complications compared with traditional open procedures. " 01/01/2018 - "The aim of this study was to compare length of stay (LOS) after robotic-assisted and open retromuscular ventral hernia repair (RVHR). " 05/01/2015 - "Numerous prospective studies and randomized controlled trials have demonstrated shorter length of stay, lower morbidity rates, and similar recurrence rates with laparoscopic ventral hernia repair (VHR) when compared to open VHR. "
2.	Herniorrhaphy 06/01/2002 - "We conclude that laparoscopic incisional herniorrhaphy offers a safe and effective repair for large primary and recurrent ventral hernia with low morbidity." 09/01/1999 - "Laparoscopic ventral herniorrhaphy, a recent development, has been shown to be safe and effective in the repair of ventral hernias. " 08/01/2013 - "We describe a new adjunctive technique that may be helpful in repairing difficult ventral hernias: it involves using an appropriately chosen, redundant abdominal skin edge that is deepithelialized and used to reinforce the hernia repair. " 01/01/2008 - "Although ventral hernias are electively repaired in younger patients, the safety and efficacy of elective laparoscopic hernia repair in the geriatric age group is not well documented in the literature. " 10/25/2023 - "The main goal of our study was to analyze the UR30 following groin hernia repair (GHR), primary- (PVHR), and incisional ventral hernia repairs (IVHR). "
3.	Sutures (Suture) 05/01/2014 - "Further high-quality studies are necessary to determine whether suture or mesh repair leads to improved outcomes for primary ventral hernias." 02/01/2022 - "Conclusion The barbed suture closure technique is a fast, safe, and effective technique for fascial closure during laparoscopic ventral hernia repair in combination with mesh placement. " 02/01/2022 - "Purpose The aim of this study is to describe the safety and effectiveness of laparoscopic ventral hernia repair with intraperitoneal fascial closure using a barbed suture prior to mesh placement. " 01/01/2019 - "Nationwide Propensity-Score Matched Study of Mesh Versus Suture Repair of Primary Ventral Hernias in Women with a Subsequent Pregnancy." 01/01/2016 - "The study aim was to identify residents' coordination between dominant and nondominant hands while grasping for sutures in a laparoscopic ventral hernia repair procedure simulation. "
4.	Prostheses and Implants (Prosthesis) 01/01/2018 - "Treatment of postoperative ventral hernias using synthetic endoprostheses in recipients of solid organs is effective and safe and should be considered as a preferable in treatment of this pathology. " 02/01/2012 - "We compared the performance and efficacy of two non-crosslinked meshes in ventral hernia repair to two crosslinked prostheses in a rodent model. " 11/01/1994 - "Surgical repair of ventral hernias may often be quite difficult; however, the use of prosthesis, now generally accepted by many surgeons, has improved the results of such type of surgery. " 01/01/2018 - "Further studies are needed to determine which method results in optimally sized abdominal wall prostheses and superior ventral hernia repair." 02/01/2012 - "Clinical studies and preclinical animal models have attempted to determine the adhesion characteristics and effectiveness of barrier mesh prostheses available for ventral hernia repair applications. "
5.	Operative Time 01/01/2021 - "Although the robotic approach did required a longer operative time, the resulting improved patient outcomes support this technique for complex ventral hernia repairs." 11/20/2020 - "The purpose of this study is to present a CUSUM LC based on the operative times of robotic intraperitoneal onlay mesh (rIPOM) ventral hernia repair (VHR) and identify differences observed throughout its phases. " 08/01/2010 - "This study aimed to delineate the risk factors that can be identified in the preoperative setting predictive of longer operative times and complexity in laparoscopic ventral hernia repair. " 11/01/2022 - "Median operative time was longer for all robot-assisted approaches as compared to laparoscopic or open techniques with the largest difference seen between open and robot-assisted primary ventral hernia repair (unadjusted difference of 93 min, P < 0.001). " 01/01/2021 - "When compared with open ventral hernia repair, the laparoscopic ventral hernia repair group had higher mean body mass index, less patients with American Society of Anesthesiologists class ≥III, fewer emergency operations, longer operative time, less complications, decreased mortality, and shorter duration of stay. "