Hernia (Hernias)

Protrusion of tissue, structure, or part of an organ through the bone, muscular tissue, or the membrane by which it is normally contained. Hernia may involve tissues such as the ABDOMINAL WALL or the respiratory DIAPHRAGM. Hernias may be internal, external, congenital, or acquired.

Also Known As:

Networked: 6433 relevant articles (231 outcomes, 581 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hernia (Hernias)
2.	Pain (Aches)
3.	Inguinal Hernia (Direct Inguinal Hernia)
4.	Wounds and Injuries (Trauma)
5.	Postoperative Pain

Experts

1.	Klinge, U: 37 articles (01/2016 - 01/2000)
2.	Schumpelick, V: 36 articles (04/2010 - 01/2000)
3.	Junge, K: 28 articles (08/2014 - 01/2002)
4.	Klosterhalfen, B: 17 articles (06/2012 - 01/2000)
5.	Rosch, R: 16 articles (11/2010 - 09/2002)
6.	Bittner, R: 15 articles (12/2015 - 03/2000)
7.	Franz, Michael G: 14 articles (11/2015 - 01/2004)
8.	Rosenberg, Jacob: 14 articles (11/2015 - 02/2006)
9.	Lange, Johan F: 14 articles (10/2015 - 03/2007)
10.	Jeekel, J: 14 articles (08/2015 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hernia:

1.	Polypropylenes (Polypropylene)IBA 11/01/2002 - "In our opinion prophylactic use of polypropylene mesh in bariatric patients is highly effective in postoperative hernia prevention." 01/01/2011 - "The application of polypropylene endoprosthesis for the treatment of postoperative hernias allows obtaining 36.4% more good results as compared with the control group, 21.7% decreased number of satisfactory results and no recurrent hernias." 02/01/1968 - "An old technique for the repair of incisional hernias, but with the use of Marlex mesh instead of fascia lata, was used in eight cases, with good results for the limited time the patients have been observed. " 10/01/2004 - "From a surgeon's point of view, the mesh plug repair is superior to the Lichtenstein technique and the Prolene Hernia System in terms of operating time, incision length, perceived difficulty, and surgeon's satisfaction." 02/01/2008 - "For the larger hernias, we used two meshes to cover the defect--polypropylene and Parietex, sizes being 15 x 15 cm. Laparoscopic repair with prosthetic reinforcement is feasible and effective in the treatment of lumbar incisional hernias. "
2.	tetra-4-amidinophenoxypropane (TAPP)IBA 03/01/2012 - "Using the laparoscopic TAPP hernia repair as a standardised operation, changing from 12-mm fascial port closure to a technique that uses port dilation (not requiring a potentially "tight" deeper fascial closure) in a similar group of patients shows that there is a significant reduction in postoperative analgesic requirement and an earlier return to productive work or normal lifestyle. " 03/01/2010 - "Laparoscopic TAPP is an acceptable method of spigelian hernia repair with good results and low recurrence rates. " 10/01/2008 - "A variety of commonly encountered inguinal and groin hernias were treated by TAPP with good results, minimal morbidity (4.39%) and one mortality. " 09/01/2001 - "Laparoscopic TAPP hernia repair is technically difficult, but in the hands of a well-trained surgeon, it is safe and effective with a high degree of patient satisfaction. " 10/01/1996 - "Our results support other studies and randomized trials reported in the literature and demonstrate that TAPP is an effective and safe operative procedure especially for the repair of recurrent groin hernias."
3.	tetraethylpyrazine (TEP)IBA 07/01/2003 - "In a representative patient population with recurrent hernia, we were able to demonstrate that TEP achieves very good results in terms of re-recurrence rate, intraoperative and postoperative complications, and rehabilitation. " 04/01/2014 - "Laparoendoscopic single site surgery TEP hernia repair is a relatively new technique and appears to be safe and effective. " 08/01/2012 - "Single-port laparoscopic surgery (SPLS) for totally extraperitoneal (TEP) groin hernia repair is a novel procedure, ensuring safe and effective repairs. " 03/01/2011 - "Therefore, the purpose of this study was to determine the safety and efficacy of transection of the hernia sac during laparoscopic TEP. " 11/01/2015 - "Laparoscopic totally extraperitoneal hernia repair (TEP) has been compared with the open technique in several studies in terms of technical properties and perioperative outcomes. "
4.	CollagenIBA 08/01/2011 - "For parastomal hernias within the rectus sheath, diisocyanate cross-linked porcine dermal collagen mesh onlay repair gives good results and is safe to use. " 08/01/2008 - "The aim of our study was to investigate whether this novel collagen-based biological matrix is safe and effective for the repair of abdominal wall hernia defects in a rat model. " 05/01/2015 - "Although there are some promising results, at present, in-depth understanding of the pathophysiological mechanismsand of the role that collagens play in the development and recurrence of incisional hernia is rather scarce. " 09/01/2006 - "The results of these few cases confirm the safety and efficacy of the porcine dermal collagen mesh also in incisional hernia repair." 02/01/2015 - "This study aimed to investigate the effectiveness of porcine dermal collagen (PDC) as a closing aid in giant hernias after OLT in a prospective trial. "
5.	CosmeticsIBA 10/01/2004 - "The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction. " 07/01/2015 - "At the follow-up evaluation after approximately 30 months, abdominal wall mobility and cosmetic satisfaction were equally positive, with no hernia recurrence. " 06/01/2015 - "This has led to the development of single incision laparoscopic hernia repair (SIL) which can further reduce the port-related morbidities and improve cosmetic outcomes. " 01/01/2015 - "There are various methods for surgical treatment of hernia and hydrocele in children with variable cost-effectiveness, recovery and cosmetic outcomes. " 10/01/2014 - "SILC outcomes largely depend on surgeon's skill, but regardless of it, when compared to MLC, SILC requires somewhat longer operating time, risk of incisional hernia is higher (but overall very low) and early cosmetic benefit is modest. "
6.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 02/01/2006 - "The preliminary results suggest that Tissucol application has no adverse effects, is not time-consuming, and may be effective in preventing leaks and internal hernias in morbidly obese patients undergoing LRYGBP." 10/01/2007 - "The present study aims to evaluate the efficacy of mesh fixation with human fibrin glue (Tissucol) in open, tension-free inguinal repair, in the treatment of soccer players with groin hernia. " 07/01/2012 - "The aim of this systematic review is to summarize the clinical safety and efficacy of Tisseel/Tissucol fibrin sealant for hernia mesh fixation. " 11/01/2013 - "The study could not differentiate between different hernia defect sizes, and future studies should therefore explore whether the superior effect of fibrin sealant applies for all hernia types and sizes." 11/01/2013 - "The current study compared reoperation rates after laparoscopic groin hernia repair between fibrin sealant and tacks used for mesh fixation. "
7.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 04/01/2011 - "This study was designed to evaluate the pre- vs. post-incisional analgesic efficacy of bupivacaine administered caudally in children undergoing unilateral hernia repair. " 04/01/2012 - "Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial." 03/01/1987 - "Intraoperative bupivacaine during outpatient hernia repair in children: a randomized double blind trial." 08/01/2012 - "Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device." 10/01/2009 - "Higher BMI and recurrent hernia also caused a higher need for bupivacaine. "
8.	Biocompatible Materials (Biomaterials)IBA 06/01/2008 - "The increased use of biomaterials for the repair of abdominal wall hernias has achieved a significant reduction in recurrences and consequently improved the quality of life of patients. " 02/01/2012 - "The authors review the recent literature regarding the efficacy of these synthetic materials and biomaterials in incisional hernia repair, as well as share their experience in treating complex abdominal wall defects using components separation and biologic mesh." 09/01/2015 - "CRITICAL ANALYSIS OF EXPERIMENTAL MODEL FOR STUDY OF ADHESIONS AFTER INCISIONAL HERNIAS INDUCED IN RATS' AND REPAIR OF ABDOMINAL WALL WITH DIFFERENT BIOMATERIALS." 08/01/1995 - "A study was made of the distinct biomaterials used in surgery and the requirements to be fulfilled and principles applied for their use in the repair of abdominal wall hernias. " 10/01/2015 - "This review outlines some new advances in abdominal wall hernia management focusing on hernia prevention, preoperative strategies to improve outcomes, available biomaterials and mesh products used in hernia repair, new surgical techniques, and improving ways to evaluate outcomes and perform continuous quality improvement in hernia repair. "
9.	ropivacaine (Naropin)FDA LinkGeneric 11/01/2014 - "The results of this study do not support adding an ambulatory, continuous ropivacaine infusion to a single-injection ropivacaine TAP block for hernia surgery. " 11/01/2014 - "Therefore, the aim of this randomized, triple-masked, placebo-controlled study was to determine if benefits are afforded by adding a multiple-day, ambulatory, continuous ropivacaine TAP block to a single-injection block following hernia surgery. " 07/01/2015 - "Group A patients received hernia block by conventional method using 0.75% ropivacaine 15 ml, and Group B patients were given the block guided by ultrasound using 0.75% ropivacaine, till the nerves were surrounded on all sides by the drug. " 03/01/1999 - "Ropivacaine 0.25% and 0.5% is adequate for pain relief after outpatient hernia repair, whereas the 0.125% solution is no more effective than saline. " 03/01/1998 - "Infiltration of ropivacaine 7.5 mg/mL during hernia surgery can be employed safely in doses of 300 mg and 375 mg to control pain after hernia surgery. "
10.	Polytetrafluoroethylene (Teflon)FDA Link 10/01/2003 - "We conducted a multiinstitutional study of adhesions to implanted expanded polytetrafluoroethylene (ePTFE) mesh at reoperation in patients who had previously undergone laparoscopic incisional hernia repair done with the same mesh implantation technique. " 08/01/2003 - "We conducted a multi-institutional study of adhesions to implanted expanded polytetrafluoroethylene (ePTFE) mesh at reoperation in patients who had previously undergone laparoscopic incisional hernia repair done with the same mesh implantation technique. " 03/01/2003 - "Comparison of PTFE, pericardium bovine and fascia lata for repair of incisional hernia in rat model, experimental study." 07/01/1998 - "A standard technique for laparoscopic ventral hernioplasty (peritoneal onlay using an expanded polytetrafluoroethylene [ePTFE] patch for hernias >/=4 cm2) is being used in a prospective, multicenter, long-term study. " 07/01/1997 - "Few large studies of the use of expanded polytetrafluoroethylene (ePTFE) in incisional hernia repairs have been done. "

Therapies and Procedures

1.	Sutures (Suture) 04/01/2012 - "After clearance of the abdominal wall from adhesions, laparoscopic central closures were performed transcutaneously with 0-polypropelene sutures placed every 1 cm of the defect starting at the cranial-most edge of the hernia and ending at the caudal-most edge of the hernia. " 11/01/2007 - "The laparoscopic incisional hernia repair using mesh after complete dissection of adhesion and fixation with stapler and suture is a safe and effective procedure for aged patients." 06/01/2014 - "The parastomal hernia rate was significantly greater in the anterior fascial suture group (43 of 281; 15.3%) than the no fascial suture group (12 of 164; 7.3%; P=.02). " 01/01/2010 - "Randomised controlled trials with a long term follow-up (3 to 10 years) have demonstrated that mesh repair is superior to suture closure of incisional hernia with lower recurrence rates (5 to 20% versus 20 to 63%). " 04/01/2009 - "In our experience, the incision of the peritoneum lateral to the internal inguinal ring and the W-shaped suture, compared to the sole W-shaped suture, is safe and effective in preventing hernia recurrence."
2.	Prostheses and Implants (Prosthesis) 10/01/1997 - "The employment of prosthesis in abdominal plastic surgery for incisional hernia has contributed to a remarkable improvement in the results of this surgery. " 04/01/1984 - "The good results reported allow the statement that, without ruling out classic techniques for simpler cases, surgical repair using prostheses offers an excellent opportunity for use and for preventing the recurrence of hernias." 06/01/2011 - "Various studies have shown that laparoscopic hernia repair is safe and effective, and carries a lower morbidity than the open approach, but the high recurrence rates still being reported (ranging from 10 to 42%) have prompted many authors to recommend using a prosthesis. " 02/01/2010 - "It is hoped that these suggestions will lead to the development of improved hernia treatments and a maximally effective portfolio of hernia mesh prostheses." 03/01/2008 - "Inserting a mesh prosthesis by this technique is a safe effective treatment for parastomal hernia, adding another option to the available repair solutions. "
3.	Laparotomy 01/01/1986 - "The risk of developing a hernia was significantly greater in patients over 40 years of age, women of parity greater than 3, patients who had had undergone more than 3 laparotomies and those with a previous hernia repair. " 07/01/1981 - "Among the laparotomy and hernia group who developed a DVT, coagulability was significantly greater both before and during the operation and on the first post-operative day." 07/01/2000 - "Parastomal hernia repair without laparotomy or mesh is a safe and effective method of repair." 08/01/2013 - "A reduced incidence of incisional hernia was observed when laparotomy was combined with prophylactic mesh placement in pooled analysis of RCTs (pooled odds ratio = 0.32; 95 % confidence interval = 0.12-0.83; P = 0.02) and comparative studies (pooled odds ratio = 0.11; 95 % confidence interval = 0.04-0.33; P < 0.001) respectively. " 11/16/1901 - "An Improved Incision in Laparotomy for the Prevention of Post-Operative Hernia."
4.	Transplants (Transplant) 06/01/2002 - "A great variety of surgical techniques have been proposed to repair large abdominal incisional hernias, but the best results are achieved using synthetic grafts as in the Rives' or Ramirez' procedure. " 02/01/2011 - "Large ventral incisional hernias can be effectively treated by the intraperitoneal placement of Parietex(®) composite mesh overlaid by an aponeurotic graft; the incidence of complications in this prospective study was very low." 03/01/2009 - "Are biologic grafts effective for hernia repair?: a systematic review of the literature." 02/01/2013 - "Tension-free repair of large incisional hernia with autodermal grafts was unjustly neglected despite the fact that it is safe and effective. " 07/01/2011 - "Bacterial clearance of biologic grafts used in hernia repair: an experimental study."
5.	General Anesthesia 04/01/2003 - "Laparoscopy was accomplished through ipsilateral hernia sac to determine the viability of the incarcerated bowel segment under general anesthesia, following spontaneous reduction under general anesthesia. " 04/01/2003 - "Local or general anesthesia for open hernia repair: a randomized trial." 07/01/1993 - "The study included 38 patients (36 male and two female) who had an acceptable risk for general anesthesia, presented electively, and gave informed consent; patients were excluded for whom general anesthesia had a high risk or who had incarcerated or strangulated hernias. " 02/01/2015 - "Is laparoscopy needed for incarcerated hernias that became reducible during induction of general anesthesia?" 01/01/2015 - "A 21-day-old Chinese baby girl who had an incarcerated hernia received an emergent exploratory operation under general anesthesia. "