Heptaminol

An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.

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Networked: 28 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fu, Deyu: 1 article (06/2020)
2.	Li, Qiang: 1 article (06/2020)
3.	Shi, Yanan: 1 article (06/2020)
4.	Wang, Mingzhu: 1 article (06/2020)
5.	Wang, Youhua: 1 article (06/2020)
6.	Yao, Lei: 1 article (06/2020)
7.	Cheon, Seon Ah: 1 article (07/2016)
8.	Chung, Jinhyuk F: 1 article (07/2016)
9.	Joo, Min Young: 1 article (07/2016)
10.	Kim, Bumju: 1 article (07/2016)

Related Diseases

1.	Premenstrual Syndrome (Premenstrual Tension) 03/01/1985 - "The efficacy of the adenosine phosphate of heptaminol on the functional symptomatology of the premenstrual syndrome has been assessed in the framework of an "open" controlled trial against a reference product. " 03/01/1985 - "[Heptaminol adenosine phosphate and the premenstrual syndrome]."
2.	Hypotension (Low Blood Pressure) 04/01/1969 - "[Clinical trials of heptaminol acefyllinate in the prevention of hypotension following neuroleptic treatment]." 07/01/2015 - "Drugs for hypotension: disproportionate harms with etilefrine and heptaminol. " 08/15/1990 - "The pharmacological properties of heptaminol as an anti-hypotension agent may partially account for its inhibitory effect on catecholamine uptake and release." 01/01/1955 - "3. Effects of heptaminol hydrochloride on post-barbiturate hypotension and cardiac insufficiency]." 06/01/1986 - "In the present study the effects of thyrotropin releasing hormone (TRH) and its stable analogue, CG3703, on cardiac output (thermodilution, Cardiomax) and regional blood flow (BF; directional pulsed Doppler technique) were investigated in hypovolemic hypotension in the rat. "
3.	Orthostatic Hypotension (Postural Hypotension) 01/01/1991 - "Heptaminol hydrochloride is widely used for the treatment for orthostatic hypotension. " 01/01/1991 - "In the rat, heptaminol hydrochloride prevented orthostatic hypotension, and increased the noradrenaline plasma concentration. " 01/01/1990 - "In this double-blind vs placebo trial, the potency, so far unproven, of the injectable form of a 626 mg dose of heptaminol chlorhydrate on spontaneous or induced orthostatic hypotension (OH), was assessed. " 01/01/1990 - "Randomized double-blind trial of injectable heptaminol for controlling spontaneous or bromocriptine-induced orthostatic hypotension in parkinsonians." 05/01/1974 - "[Postural hypotension induced by neuroleptics: Rheographic study of the effects of corrective agents: Neosynephrine, dihydroergotamine, and heptaminol hydrochloride]."
4.	Hypovolemia 06/01/1986 - "In the present study the effects of thyrotropin releasing hormone (TRH) and its stable analogue, CG3703, on cardiac output (thermodilution, Cardiomax) and regional blood flow (BF; directional pulsed Doppler technique) were investigated in hypovolemic hypotension in the rat. "
5.	Varicose Veins (Varicose Vein) 01/01/1989 - "Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins." 01/01/1989 - "Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. "

Related Drugs and Biologics

1.	Adenine Nucleotides
2.	Antipsychotic Agents (Antipsychotics)
3.	Catecholamines
4.	Adrenergic Agents (Adrenergic Drugs)
5.	Thyrotropin-Releasing Hormone (Protirelin)
6.	Phenylephrine (Neo-Synephrine)
7.	Dihydroergotamine (Agit)
8.	Bromocriptine (Parlodel)
9.	hydroxide ion
10.	Aminophylline (Carine)

Related Therapies and Procedures

1.	Injections