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HEPES

A dipolar ionic buffer.

Also Known As:

HEPES Monosodium Salt; Monosodium Salt, HEPES; N 2 Hydroxyethylpiperazine N' 2' ethanesulfonic Acid; Salt, HEPES Monosodium; N-2-Hydroxyethylpiperazine-N'-2'-ethanesulfonic Acid; 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

Networked: 145 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsai, Chien-Sung: 5 articles (08/2015 - 05/2002)
2.	Loh, Shih-Hurng: 5 articles (08/2015 - 05/2002)
3.	Lemasters, John J: 3 articles (04/2012 - 06/2004)
4.	Kim, Jae-Sung: 3 articles (04/2012 - 06/2004)
5.	Jin, Jong-Shiaw: 3 articles (10/2005 - 05/2002)
6.	Tsai, Yi-Ting: 2 articles (08/2015 - 10/2014)
7.	Lee, Chung-Yi: 2 articles (08/2015 - 10/2014)
8.	Chuang, Chao-Chin: 2 articles (08/2015 - 06/2002)
9.	Chang, Chung-Yi: 2 articles (10/2014 - 10/2005)
10.	Cheng, Tzu-Hurng: 2 articles (10/2014 - 05/2002)

Related Diseases

1.	Acne Vulgaris 03/01/2013 - "This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin®, clindamycin 1% and benzoyl peroxide 5% gel). " 03/01/2013 - "Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris."
2.	Acidosis 01/11/2008 - "Under 50 mM intracellular HEPES buffer condition, extracellular acidosis inhibits TRPC5 with pKa of 5.40. " 05/01/2000 - "When cells in HEPES-buffered medium at normal pH = 7.70 were transferred to normal CO2/HCO3(-)-buffered medium ¿PCO2 = 3.71 mmHg, [HCO3-] = 6.1 mmol l(-1), extracellular pH (pHe) = 7.70¿, they exhibited a brief acidosis but subsequently regulated the same pHi (approximately 7.41) as in HEPES. " 01/01/1998 - "Acidosis was achieved by supplying excessive CO2 or by HCO3-decrease in standard bicarbonate-containing buffer or by a direct acidification of the buffer containing Na-HEPES. " 01/12/1996 - "After an intracellular acidosis induced by an NH4Cl prepulse, the initial velocity of recovery (d(pH)/dt(i), in pH units/min) was 3.32 +/- 0.69 in Hepes-buffered solution and 2.85 +/- 0.88 in HCO3- media. " 10/01/1990 - "Under these conditions, the NH4Cl-induced 22Na+ influx rate stimulated by intracellular acidosis was markedly attenuated in HEPES-buffered PSS but not in CO2/HCO3(-)-buffered PSS. "
3.	Ischemia 12/01/1993 - "Oxygenated preperfusion with buffer containing HEPES and 1.25 or 2.5 mM Ca2+ improved the metabolic and functional recovery with a decrease in the accumulation of Na+i during ischemia and in 45Ca2+ uptake during reperfusion. " 04/01/2012 - "Cultured rat hepatocytes were incubated in anoxic Krebs-Ringer-HEPES buffer at pH 6.2 for 4 h and then reoxygenated at pH 7.4 to simulate ischemia-reperfusion. " 05/01/2006 - "Myocytes were incubated in anoxic Krebs-Ringer-HEPES buffer at pH 6.2 for 3 h to simulate ischemia. " 01/01/2002 - "Experimental group (group E), after ischemia, was perfused with pH 6.8, pH 7.1 and pH 7.4 HEPES-KH solutions for 5 min, 5 min, and 20 min, respectively. " 01/01/2002 - "Control group (C) was perfused only with pH 7.4 HEPES-KH solution for 90 min. Ischemia/reperfusion group (group I/R) was perfused with pH 7.4 HEPES-KH solution before ischemia or after ischemia. "
4.	Rubella (German Measles) 04/01/1971 - "The increased sensitivity and improved agglutination and settling patterns of formalinized sheep erythrocytes in a new buffer, HEPES (N-2-hydroxyethylpiperazine N'-2'-ethanesulfonic acid), make this system more suitable for use in the rubella hemagglutination-inhibition test." 09/01/1971 - "In HEPES diluents, rubella antigens agglutinated a wide range of species of erythrocytes, and the hemagglutination reaction showed little or no dependence on low temperatures." 01/01/1977 - "Optimal conditions for the agglutination of freeze-dried erythrocytes by rubella hemagglutinin were provided when a HEPES-buffered saline at pH 6.2, containing 10(-3) M CaCl2, 0.2 per cent bovine serum albumin, and 0.0025 per cent gelatin was employed throughout as a diluent for serum, hemagglutinin, and freeze-dried erythrocyte suspension. "
5.	Neoplasms (Cancer) 11/01/1989 - "The results showed that optimal tumor cell colony growth was achieved in 100 ul capillary tubes of 1.2 mm internal diameter filled with 30ul, yielding a gel length of 27 mm. Colony formation did not significantly differ between sealed and unsealed tubes, provided that HEPES buffer was added. " 08/11/1995 - "Tumor-derived GH4C1 cells and collagenase-dispersed normal anterior pituitary (AP) cells from young adult male rats were perifused with Krebs-Ringer Hepes medium. " 11/10/1988 - "The addition of pyruvate (1 mM) to EMEM with 5% fetal calf serum (FCS) stimulated 98.8% (P less than 0.01) and 50.6% (P less than 0.1) increases in tumor binding and cytolysis, respectively compared with EMEM/5% FCS alone, while Hepes (25 mM) stimulated 58.3% (P less than 0.01) and 37.5% (P less than 0.1) increases in these activities. " 01/01/1984 - "Measurements of QO2 of suspension of MCaIV and FSaII cells from freshly excised tumor tissue have been measured for cells suspended in PBS, Hank's buffered with HEPES +/- glutamate. " 04/01/1977 - " Tumors were removed when they reached the size of 2 X 4 cm and sliced to a thickness of .5 mm. Sections cut from the slices were incubated for 3 hours in medium 199 (1% bovine serum albumin, 5 mM CaC12, 5mM HEPES buffer) at pH 7.4 and 400,000 counts/minute of iodine-125-ovine prolactin in the presence or absence of 1 mcg of unlabeled prolactin. "

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Salicylic Acid (2 Hydroxybenzoic Acid)
3.	Clindamycin (Cleocin)
4.	Benzoyl Peroxide
5.	glycolic acid (glycolate)
6.	Glucose (Dextrose)
7.	Insulin (Novolin)
8.	Pyruvic Acid (Pyruvate)
9.	Estradiol (Estrace)
10.	Collagenases (Collagenase)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Microelectrodes
3.	Electrodes (Electrode)