Hepatitis B Core Antigens

08/10/1998 - "Despite its limitations, the present study demonstrates (1) the safety of treatment with high titers of retroviral vector in chimpanzees, (2) the capability of a retroviral vector expressing HBcAg to stimulate immune responses in HBV chronic carrier chimpanzees, and (3) that retroviral vector immunization may be therapeutically beneficial in the treatment of chronic HBV infection."
10/01/2001 - "T-cell immunity against viral nucleocapsid (HBcAg or WHcAg) has been shown to play a critical role in viral clearance and protection against infection. "
03/01/1985 - "Protection against hepatitis B virus infection by immunization with hepatitis B core antigen."
04/01/2006 - "The aim of this study was to determine whether the degree of expression of HBcAg in the hepatocyte nucleus and cytoplasm reflects the level of viral replication and histological activity in chronic HBV infection. "
01/01/2005 - "This study is to test the infection efficiency of recombinant adeno-associated virus carrying hepatitis B core antigen (rAAV-HBV-c) to DCs and the growth and maturity of them. "

04/01/1985 - "Widespread presence of cytoplasmic HBcAg in hepatitis B infected liver detected by improved immunochemical methods."
01/01/2011 - "The goal of this study is to observe changes in HBcAg-specific cytotoxic T lymphocytes (CTLs), natural killer (NK) and natural killer T (NKT) cells from peripheral blood and to relate such changes on viral clearance and liver injury in patients with acute hepatitis B (AHB). "
06/01/2009 - "Previous studies demonstrated that the primary APCs for the hepatitis B core Ag (HBcAg) were B cells and not dendritic cells (DC). "
10/01/2015 - "Significance of Response to Hepatitis B Recombinant Vaccine in Subjects with Isolated Antibody to Hepatitis B Core Antigen."
10/01/2013 - "PreS1 aa21-47 epitope and aa 37-45 epitope were inserted respectively into full-length hepatitis B core (aa 1-183) and truncated HBcAg (aa 1-144), between the 78th (Asp) and 79th (Pro). "

12/17/2004 - "HBcAg-specific CTL cells may play a crucial role in complete clearance of HBV from patients with acute HBV hepatitis."
11/01/2003 - "In the presented studies HBcAg-specific cytokine production (IFN-gamma, IL-2, IL-4, IL-5 and IL-10) was evaluated, by Th lymphocytes isolated from peripheral blood of children with acute or chronic B hepatitis. "
03/01/1997 - "During the 10 years following the first dose of vaccine, 13 study participants developed antibody to hepatitis B core antigen (10 vaccine responders, 3 nonresponders), and none developed sustained HBs positivity or had clinical hepatitis. "
06/01/1987 - "[An immunohistochemical study of HBcAg in the liver of patients with type B hepatitis]."
01/01/2011 - "Prevention of post-transfusion hepatitis by screening of antibody to hepatitis B core antigen in healthy blood donors."

12/01/2014 - "Antibody to hepatitis B core antigen levels in the natural history of chronic hepatitis B: a prospective observational study."
11/01/2013 - "HBcAg-specific IL-21-producing CD4+ T cells are associated with relative viral control in patients with chronic hepatitis B."
02/01/2012 - "HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients."
07/15/2010 - "HBcAg-specific regulatory T (T(reg)) cells play an important role in the pathogenesis of chronic hepatitis B. "
02/01/2009 - "Likewise, proliferation in response to DC-presented HBcAg was detected in both CD4(+) and CD8(+) T cells from the majority of chronic hepatitis B patients. "

10/01/2011 - "Patients with AVH had the highest T cell response to HBcAg, which probably explains the clearance of virus in these patients, in contrast to patients with cirrhosis who had the lowest T cell response."
04/01/2011 - "The presence of nuclear expression of HBcAg did not show any correlations with ALT levels, HAI and fibrosis score. "
12/01/2008 - "The stage of fibrosis was higher (3.31+/-1.34 vs. 2.43+/-1.39, mean+/-SD, p<0.01) and the grade of necroinflammatory activity was higher (9.39+/-3.11 vs. 6.13+/-3.40, p<0.001) for the cytoplasmic expression of HBcAg (cHBcAg) than for the nuclear expression of HBcAg (nHBcAg). "
06/01/1997 - "Two-D distance distribution analysis: an application to HBcAg-positive hepatocytes and its relation to septum formation in cirrhosis."
04/01/1995 - "It was found that in liver HBxAg was present in 72.7% of the patients with chronic active hapatitis (CAH) and 92.6% of those with cirrhosis, while the positivity rate of HBcAg in cirrhosis patients was only 47.8%. "